Access the full text.
Sign up today, get DeepDyve free for 14 days.
Joon‐Kyu Lee, K. Moon, Y. Jiang, J. Hurwitz (2001)
The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 proteinProceedings of the National Academy of Sciences of the United States of America, 98
E. Enemark, E. Enemark, Grace Chen, Grace Chen, D. Vaughn, D. Vaughn, A. Stenlund, L. Joshua-Tor, L. Joshua-Tor (2000)
Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus.Molecular cell, 6 1
M. Lusky, J. Hurwitz, Y. Seo (1994)
The bovine papillomavirus E2 protein modulates the assembly of but is not stably maintained in a replication-competent multimeric E1-replication origin complex.Proceedings of the National Academy of Sciences of the United States of America, 91 19
E. Enemark, A. Stenlund, L. Joshua-Tor (2002)
Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complexThe EMBO Journal, 21
J. Sedman, A. Stenlund (1996)
The initiator protein E1 binds to the bovine papillomavirus origin of replication as a trimeric ring‐like structure.The EMBO Journal, 15
T. Gillette, M. Lusky, J. Borowiec (1994)
Induction of structural changes in the bovine papillomavirus type 1 origin of replication by the viral E1 and E2 proteins.Proceedings of the National Academy of Sciences of the United States of America, 91 19
Liu Yang, Ian Mohr, E. Fouts, Daniel Lim, Michael Nohaile, M. Botchan (1993)
The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.Proceedings of the National Academy of Sciences of the United States of America, 90 11
A. Johnson, A. Poteete, G. Lauer, R. Sauer, G. Ackers, M. Ptashne (1981)
λ Repressor and cro—components of an efficient molecular switchNature, 294
F Sverdrup, G Myers (1997)
The E1 proteinsJ Virol
S. Bell (2002)
The origin recognition complex: from simple origins to complex functions.Genes & development, 16 6
Steve Titolo, A. Pelletier, F. Sauvé, Karine Brault, E. Wardrop, P. White, A. Amin, M. Cordingley, J. Archambault (1999)
Role of the ATP-Binding Domain of the Human Papillomavirus Type 11 E1 Helicase in E2-Dependent Binding to the OriginJournal of Virology, 73
I. Mohr, R. Clark, Shaw Sun, E. Androphy, Paul MacPherson, M. Botchan (1990)
Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator.Science, 250 4988
R. Chuang, L. Chrétien, Jianli Dai, T. Kelly (2002)
Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein.The Journal of biological chemistry, 277 19
H. Lin, R. Upson, D. Simmons (1992)
Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activityJournal of Virology, 66
L. Yang, I. Mohr, R. Li, T. Nottoli, S. Sun, M. Botchan (1991)
Transcription factor E2 regulates BPV-1 DNA replication in vitro by direct protein-protein interaction.Cold Spring Harbor symposia on quantitative biology, 56
D. Coverley, R. Laskey (1994)
Regulation of eukaryotic DNA replication.Annual review of biochemistry, 63
Xuelian Luo, D. Sanford, P. Bullock, W. Bachovchin (1996)
Solution structure of the origin DNA-binding domain of SV40 T-antigenNature Structural Biology, 3
MS VanLoock, A Alexandrov, X Yu, NR Cozzarelli, EH Egelman (2002)
SV40 large T antigen hexamer structure. Domain organization and DNA‐induced conformational changesJ Virol, 12
Grace Chen, A. Stenlund (1998)
Characterization of the DNA-Binding Domain of the Bovine Papillomavirus Replication Initiator E1Journal of Virology, 72
S. Deb, A. Delucia, C. Baur, A. Koff, P. Tegtmeyer (1986)
Domain structure of the simian virus 40 core origin of replicationMolecular and Cellular Biology, 6
Ellen Fanning, Rolf Knippers (1992)
Structure and function of simian virus 40 large tumor antigen.Annual review of biochemistry, 61
Tiina Sedman, J. Sedman, Andarne Stenlund (1997)
Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirusJournal of Virology, 71
C Voitenleitner, M Botchan (2002)
E1 protein of bovine papillomavirus type 1 interferes with E2 protein‐mediated tethering of the viral DNA to mitotic chromosomesCold Spring Harb Symp Quant Biol, 76
H. Rao, B. Stillman (1995)
The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.Proceedings of the National Academy of Sciences of the United States of America, 92 6
M. Valle, C. Gruss, L. Halmer, J. Carazo, L. Donate (2000)
Large T-Antigen Double Hexamers Imaged at the Simian Virus 40 Origin of ReplicationMolecular and Cellular Biology, 20
M. Berg, A. Stenlund (1997)
Functional interactions between papillomavirus E1 and E2 proteinsJournal of Virology, 71
J. Lebkowski, S. Clancy, M. Calos (1985)
Simian virus 40 replication in adenovirus-transformed human cells antagonizes gene expressionNature, 317
L Yang, I Mohr, R Li, T Nottoli, S Sun, M Botchan (1991)
Transcription factor E2 regulates BPV‐1 DNA replication in vitro by direct protein–protein interactionProc Natl Acad Sci USA, 56
P. Masterson, M. Stanley, A. Lewis, M. Romanos (1998)
A C-Terminal Helicase Domain of the Human Papillomavirus E1 Protein Binds E2 and the DNA Polymerase α-Primase p68 SubunitJournal of Virology, 72
Grace Chen, A. Stenlund (2000)
Two Patches of Amino Acids on the E2 DNA Binding Domain Define the Surface for Interaction with E1Journal of Virology, 74
Mary Ferguson, M. Botchan (1996)
Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replicationJournal of Virology, 70
R. Aurora, W. Herr (1992)
Segments of the POU domain influence one another's DNA-binding specificityMolecular and Cellular Biology, 12
M Valle, C Gruss, L Halmer, JM Carazo, LE Donate (2000)
Large T‐antigen double hexamers imaged at the simian virus 40 origin of replicationCurr Biol, 20
H. Lorimer, E. Wang, C. Prives (1991)
The DNA-binding properties of polyomavirus large T antigen are altered by ATP and other nucleotidesJournal of Virology, 65
C. Voitenleitner, M. Botchan (2002)
E1 Protein of Bovine Papillomavirus Type 1 Interferes with E2 Protein-Mediated Tethering of the Viral DNA to Mitotic ChromosomesJournal of Virology, 76
Grace Chen, A. Stenlund (2002)
Sequential and Ordered Assembly of E1 Initiator Complexes on the Papillomavirus Origin of DNA Replication Generates Progressive Structural Changes Related to MeltingMolecular and Cellular Biology, 22
S Titolo, A Pelletier, F Sauve, K Brault, E Wardrop, PW White, A Amin, MG Cordingley, J Archambault (1999)
Role of the ATP‐binding domain of the human papillomavirus type 11 E1 helicase in E2‐dependent binding to the originMol Cell Biol, 73
L. Thorner, D. Lim, M. Botchan (1993)
DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspectsJournal of Virology, 67
S. Bell, B. Stillman (1992)
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexNature, 357
Eric Gillitzer, Grace Chen, A. Stenlund (2000)
Separate domains in E1 and E2 proteins serve architectural and productive roles for cooperative DNA bindingThe EMBO Journal, 19
S. Yang, H. Nash (1994)
Specific photocrosslinking of DNA-protein complexes: identification of contacts between integration host factor and its target DNA.Proceedings of the National Academy of Sciences of the United States of America, 91 25
D. Kong, M. DePamphilis (2001)
Site-Specific DNA Binding of the Schizosaccharomyces pombe Origin Recognition Complex Is Determined by the Orc4 SubunitMolecular and Cellular Biology, 21
Grace Chen, A. Stenlund (2001)
The E1 Initiator Recognizes Multiple Overlapping Sites in the Papillomavirus Origin of DNA ReplicationJournal of Virology, 75
C. Sanders, A. Stenlund (1998)
Recruitment and loading of the E1 initiator protein: an ATP‐dependent process catalysed by a transcription factorThe EMBO Journal, 17
D. Sigman, M. Kuwabara, C. Chen, T. Bruice (1991)
Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions.Methods in enzymology, 208
M. VanLoock, A. Alexandrov, Xiong Yu, N. Cozzarelli, E. Egelman (2002)
SV40 Large T Antigen Hexamer Structure Domain Organization and DNA-Induced Conformational ChangesCurrent Biology, 12
J. Sedman, A. Stenlund (1995)
Co‐operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.The EMBO Journal, 14
C. Sanders, A. Stenlund (2000)
Transcription Factor-dependent Loading of the E1 Initiator Reveals Modular Assembly of the Papillomavirus Origin Melting Complex*The Journal of Biological Chemistry, 275
D. Sengupta, J. Borowiec (1994)
Strand and face: the topography of interactions between the SV40 origin of replication and T‐antigen during the initiation of replication.The EMBO Journal, 13
Initiator proteins are critical components of the DNA replication machinery and mark the site of initiation. This activity probably requires highly selective DNA binding; however, many initiators display modest specificity in vitro. We demonstrate that low specificity of the papillomavirus E1 initiator results from the presence of a non‐specific DNA‐binding activity, involved in melting, which masks the specificity intrinsic to the E1 DNA‐binding domain. The viral factor E2 restores specificity through a physical interaction with E1 that suppresses non‐specific binding. We propose that this arrangement, where one DNA‐binding activity tethers the initiator to ori while another alters DNA structure, is a characteristic of other viral and cellular initiator proteins. This arrangement would provide an explanation for the low selectivity observed for DNA binding by initiator proteins.
The EMBO Journal – Wiley
Published: May 17, 2004
Keywords: ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.