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F Urano, X Wang, A Bertolotti, Y Zhang, P Chung, HP Harding, D Ron (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Science, 287
H Yoshida, T Matsui, A Yamamoto, T Okada, K Mori (2001)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorCell, 107
P Hu, Z Han, AD Couvillon, RJ Kaufman, JH Exton (2006)
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expressionMol Cell Biol, 26
R Dai, J Li, Y Liu, D Yan, S Chen, C Duan, X Liu, T He, H Li (2010)
MiR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27 Kip1- and MEK/ERK-mediated cell cycle regulationBiol Chem, 391
S Gupta, A Deepti, S Deegan, F Lisbona, C Hetz, A Samali (2010)
HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1α-XBP1 signaling through a physical interactionPLoS Biol, 8
AE Byrd, IV Aragon, JW Brewer (2012)
MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein responseJ Cell Biol, 196
JH Lin, H Li, D Yasumura, HR Cohen, C Zhang, B Panning, KM Shokat, MM LaVail, P Walter (2007)
IRE1 signaling affects cell fate during the unfolded protein responseScience, 318
S Oyadomari, M Mori (2003)
Roles of CHOP//GADD153 in endoplasmic reticulum stressCell Death Differ, 11
L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, CL Day, JM Adams, DCS Huang (2005)
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic functionMol Cell, 17
E Ullman, Y Fan, M Stawowczyk, HM Chen, Z Yue, WX Zong (2008)
Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stressCell Death Differ, 15
M Boyce, KF Bryant, C Jousse, K Long, HP Harding, D Scheuner, RJ Kaufman, D Ma, DM Coen, D Ron, J Yuan (2005)
A selective inhibitor of elF2α dephosphorylation protects cells from ER stressScience, 307
T Hayashi, TP Su (2007)
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2 + signaling and cell survivalCell, 131
U Woehlbier, C Hetz (2011)
Modulating stress responses by the UPRosome: a matter of life and deathTrends Biochem Sci, 36
H Yoshida, T Okada, K Haze, H Yanagi, T Yura, M Negishi, K Mori (2000)
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseMol Cell Biol, 20
HP Harding, I Novoa, Y Zhang, H Zeng, R Wek, M Schapira, D Ron (2000)
Regulated translation initiation controls stress-induced gene expression in mammalian cellsMol Cell, 6
AP Ghosh, BJ Klocke, ME Ballestas, KA Roth (2012)
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stressPLoS ONE, 7
D Han, AG Lerner, LV Walle, JP Upton, W Xu, A Hagen, BJ Backes, SA Oakes, FR Papa (2009)
IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fatesCell, 138
W-C Lin, Y-C Chuang, Y-S Chang, M-D Lai, Y-N Teng, I-J Su, CCC Wang, K-H Lee, J-H Hung (2012)
Endoplasmic reticulum stress stimulates p53 expression through NF-κB activationPLoS ONE, 7
B Bailly-Maitre, C Fondevila, F Kaldas, N Droin, F Luciano, JE Ricci, R Croxton, M Krajewska, JM Zapata, JW Kupiec-Weglinski, D Farmer, JC Reed (2006)
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injuryProc Natl Acad Sci USA, 103
G Szabadkai, K Bianchi, P Várnai, D Stefani, MR Wieckowski, D Cavagna, AI Nagy, T Balla, R Rizzuto (2006)
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2 + channelsJ Cell Biol, 175
R Chen, I Valencia, F Zhong, KS McColl, HL Roderick, MD Bootman, MJ Berridge, SJ Conway, AB Holmes, GA Mignery, P Velez, CW Distelhorst (2004)
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphateJ Cell Biol, 166
A Bertolotti, Y Zhang, LM Hendershot, HP Harding, D Ron (2000)
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseNat Cell Biol, 2
SJ Marciniak, CY Yun, S Oyadomari, I Novoa, Y Zhang, R Jungreis, K Nagata, HP Harding, D Ron (2004)
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumGenes Dev, 18
CG Zou, XZ Cao, YS Zhao, SY Gao, SD Li, XY Liu, Y Zhang, KQ Zhang (2009)
The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor IEndocrinology, 150
J Li, B Lee, AS Lee (2006)
Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-UP-regulated modulator of apoptosis (PUMA) and NOXA by p53J Biol Chem, 281
K Maundrell, B Antonsson, E Magnenat, M Camps, M Muda, C Chabert, C Gillieron, U Boschert, E Vial-Knecht, J-C Martinou, S Arkinstall (1997)
Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1J Biol Chem, 272
S Gupta, DE Read, A Deepti, K Cawley, A Gupta, D Oommen, T Verfaillie, S Matus, MA Smith, JL Mott, P Agostinis, C Hetz, A Samali (2012)
Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosisCell Death Dis, 3
Q Yang, YS Kim, Y Lin, J Lewis, L Neckers, ZG Liu (2006)
Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNKEMBO Rep, 7
Y Adachi, K Yamamoto, T Okada, H Yoshida, A Harada, K Mori (2008)
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumCell Struct Funct, 33
MC Bassik, L Scorrano, SA Oakes, T Pozzan, SJ Korsmeyer (2004)
Phosphorylation of BCL-2 regulates ER Ca2 + homeostasis and apoptosisEMBO J, 23
H Puthalakath, LA O’Reilly, P Gunn, L Lee, PN Kelly, ND Huntington, PD Hughes, EM Michalak, J McKimm-Breschkin, N Motoyama, T Gotoh, S Akira, P Bouillet, A Strasser (2007)
ER stress triggers apoptosis by activating BH3-only protein BIMCell, 129
A Letai, MC Bassik, LD Walensky, MD Sorcinelli, S Weiler, SJ Korsmeyer (2002)
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeuticsCancer Cell, 2
J Deng, PD Lu, Y Zhang, D Scheuner, RJ Kaufman, N Sonenberg, HP Harding, D Ron (2004)
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Mol Cell Biol, 24
HJ Chae, HR Kim, C Xu, B Bailly-Maitre, M Krajewska, S Krajewski, S Banares, J Cui, M Digicaylioglu, N Ke, S Kitada, E Monosov, M Thomas, CL Kress, JR Babendure, RY Tsien, SA Lipton, JC Reed (2004)
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressMol Cell, 15
X Luo, Q He, Y Huang, MS Sheikh (2005)
Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activationCell Death Differ, 12
WX Zong, C Li, G Hatzivassiliou, T Lindsten, QC Yu, J Yuan, CB Thompson (2003)
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosisJ Cell Biol, 162
M Kaneko, Y Niinuma, Y Nomura (2003)
Activation signal of nuclear factor-κB in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2Biol Pharm Bull, 26
A Samali, S Gupta, L Cuffe, E Szegezdi, SE Logue, C Neary, S Healy (2010)
Mechanisms of ER stress-mediated mitochondrial membrane permeabilizationInt J Cell Biol, 2010
JP Mathai, M Germain, GC Shore (2005)
BH3-only BIK regulates BAX, BAK-dependent release of Ca2 + from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell deathJ Biol Chem, 280
D Scheuner, B Song, E McEwen, C Liu, R Laybutt, P Gillespie, T Saunders, S Bonner-Weir, RJ Kaufman (2001)
Translational control is required for the unfolded protein response and in vivo glucose homeostasisMol Cell, 7
SC Cazanave, NA Elmi, Y Akazawa, SF Bronk, JL Mott, GJ Gores (2010)
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosisAm J Physiol Gastrointest Liver Physiol, 299
K Yamamoto, H Ichijo, SJ Korsmeyer (1999)
BCL-2 Is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G2/MMol Cell Biol, 19
K Du, S Herzig, RN Kulkarni, M Montminy (2003)
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liverScience, 300
M Chami, B Oulès, G Szabadkai, R Tacine, R Rizzuto, P Paterlini-Bréchot (2008)
Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stressMol Cell, 32
N Donovan, EBE Becker, Y Konishi, A Bonni (2002)
JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machineryJ Biol Chem, 277
C Reimertz, D Kögel, A Rami, T Chittenden, JHM Prehn (2003)
Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathwayJ Cell Biol, 162
I Novoa, H Zeng, HP Harding, D Ron (2001)
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2αJ Cell Biol, 153
J Ye, RB Rawson, R Komuro, X Chen, UP Davé, R Prywes, MS Brown, JL Goldstein (2000)
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsMol Cell, 6
DA Rodriguez, S Zamorano, F Lisbona, D Rojas-Rivera, H Urra, JR Cubillos-Ruiz, R Armisen, DR Henriquez, HE Cheng, M Letek, T Vaisar, T Irrazabal, C Gonzalez-Billault, A Letai, FX Pimentel-Muinos, G Kroemer, C Hetz (2012)
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1[alpha]EMBO J, 31
G Li, M Mongillo, KT Chin, H Harding, D Ron, AR Marks, I Tabas (2009)
Role of ERO1-α-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosisJ Cell Biol, 186
JR Gaut, LM Hendershot (1993)
The modification and assembly of proteins in the endoplasmic reticulumCurr Opin Cell Biol, 5
X Wang, KE Olberding, C White, C Li (2011)
Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosisCell Death Differ, 18
NS Chitnis, D Pytel, E Bobrovnikova-Marjon, D Pant, H Zheng, NL Maas, B Frederick, J Kushner, L Chodosh, C Koumenis, S Fuchs, J Diehl (2012)
miR-211 Is a prosurvival MicroRNA that regulates chop expression in a PERK-dependent mannerMol Cell, 48
C White, C Li, J Yang, NB Petrenko, M Madesh, CB Thompson, JK Foskett (2005)
The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3RNat Cell Biol, 7
PD Lu, HP Harding, D Ron (2004)
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress responseJ Cell Biol, 167
N Morishima, K Nakanishi, A Nakano (2011)
Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding proteinJ Biol Chem, 286
S Grimm (2012)
The ER-mitochondria interface: the social network of cell deathBiochim Biophys Acta, 1823
C Hetz, P Bernasconi, J Fisher, AH Lee, MC Bassik, B Antonsson, GS Brandt, NN Iwakoshi, A Schrinzel, LH Glimcher, SJ Korsmeyer (2006)
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1αScience, 312
XZ Wang, HP Harding, Y Zhang, EM Jolicoeur, M Kuroda, D Ron (1998)
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesEMBO J, 17
HP Harding, Y Zhang, H Zeng, I Novoa, PD Lu, M Calfon, N Sadri, C Yun, B Popko, R Paules, DF Stojdl, JC Bell, T Hettmann, JM Leiden, D Ron (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressMol Cell, 11
T Verfaillie, N Rubio, AD Garg, G Bultynck, R Rizzuto, JP Decuypere, J Piette, C Linehan, S Gupta, A Samali, P Agostinis (2012)
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stressCell Death Differ, 11
HM Heath-Engel, NC Chang, GC Shore (2008)
The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein familyOncogene, 27
P Pinton, D Ferrari, P Magalhaes, K Schulze-Osthoff, F Virgilio, T Pozzan, R Rizzuto (2000)
Reduced loading of intracellular Ca2 + stores and downregulation of capacitative Ca2 + influx in Bcl-2-overexpressing cellsJ Cell Biol, 148
M Kurata, Y Yamazaki, Y Kanno, S Ishibashi, T Takahara, M Kitagawa, T Nakamura (2011)
Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cellsCell Death Dis, 10
E Szegezdi, DC MacDonald, TN Chonghaile, S Gupta, A Samali (2009)
Bcl-2 family on guard at the ERAm J Physiol Cell Physiol, 296
N Ohoka, S Yoshii, T Hattori, K Onozaki, H Hayashi (2005)
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathEMBO J, 24
T Futami, M Miyagishi, K Taira (2005)
Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectorsJ Biol Chem, 280
J Hollien, JS Weissman (2006)
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein responseScience, 313
F Yang, L Zhang, F Wang, Y Wang, X Huo, Y Yin, SH Sun (2011)
Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma 1,2Neoplasia, 13
K Lei, RJ Davis (2003)
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosisProc Natl Acad Sci USA, 100
S Shimizu, T Kanaseki, N Mizushima, T Mizuta, S Arakawa-Kobayashi, CB Thompson, Y Tsujimoto (2004)
Role of Bcl-2 family proteins in a non-apoptopic programmed cell death dependent on autophagy genesNat Cell Biol, 6
H Yamazaki, N Hiramatsu, K Hayakawa, Y Tagawa, M Okamura, R Ogata, T Huang, S Nakajima, J Yao, AW Paton, JC Paton, M Kitamura (2009)
Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein responseJ Immunol, 183
KD McCullough, JL Martindale, LO Klotz, TY Aw, NJ Holbrook (2001)
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateMol Cell Biol, 21
SA Oakes, L Scorrano, JT Opferman, MC Bassik, M Nishino, T Pozzan, SJ Korsmeyer (2005)
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulumProc Natl Acad Sci USA, 102
BP Gomez, RB Riggins, AN Shajahan, U Klimach, A Wang, AC Crawford, Y Zhu, A Zwart, M Wang, R Clarke (2007)
Human X-Box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell linesFASEB J, 21
HP Harding, Y Zhang, D Ron (1999)
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseNature, 397
J Rong, L Chen, JI Toth, M Tcherpakov, MD Petroski, JC Reed (2011)
Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER stressJ Biol Chem, 286
E Buytaert, G Callewaert, JR Vandenheede, P Agostinis (2006)
Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulumAutophagy, 2
Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of many diseases including heart disease, cancer and neurodegenerative diseases such as Alzheimer’s and Huntington’s. Prolonged or excessive ER stress results in the initiation of signaling pathways resulting in cell death. Over the past decade much research investigating the onset and progression of ER stress-induced cell death has been carried out. Owing to this we now have a better understanding of the signaling pathways leading to ER stress-mediated cell death and have begun to appreciate the importance of ER localized stress sensors, IRE1α, ATF6 and PERK in this process. In this article we provide an overview of the current thinking and concepts concerning the various stages of ER stress-induced cell death, focusing on the role of ER localized proteins in sensing and triggering ER stress-induced death signals with particular emphasis on the contribution of calcium signaling and Bcl-2 family members to the execution phase of this process. We also highlight new and emerging directions in ER stress-induced cell death research particularly the role of microRNAs, ER-mitochondria cross talk and the prospect of mitochondria-independent death signals in ER stress-induced cell death.
Apoptosis – Springer Journals
Published: Feb 21, 2013
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