Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

P2 receptors in the regulation of renal transport mechanisms

P2 receptors in the regulation of renal transport mechanisms Extracellular nucleotides (e.g., ATP) regulate physiological and pathophysiological processes through activation of nucleotide P2 receptors in the plasma membrane. Examples include such diverse processes as communication from taste buds to gustatory nerves, platelet aggregation, nociception, or neutrophil chemotaxis. Over approximately the last 15 years, evidence has also accumulated that cells in renal epithelia release nucleotides in response to physiological stimuli and that these nucleotides act in a paracrine and autocrine way to activate P2 receptors and play a significant role in the regulation of transport mechanisms and cell volume regulation. This review discusses potential stimuli and mechanisms involved in nucleotide release in renal epithelia and summarizes the available data on the expression and function of nucleotide P2 receptors along the native mammalian tubular and collecting duct system. Using established agonist profiles for P2 receptor subtypes, significant insights have been gained particularly into a potential role for P2Y 2 -like receptors in the regulation of transport mechanisms in the collecting duct. Due to the lack of receptor subtype-specific antagonists, however, the in vivo relevance of P2 receptor subtypes is unclear. Studies in gene knockout mice provided first insights including an antihypertensive activity of P2Y 2 receptors that is linked to an inhibitory influence on renal Na + and water reabsorption. We are only beginning to unravel the important roles of extracellular nucleotides and P2 receptors in the regulation of the diverse transport mechanisms of the kidney. kidney; ATP; UTP; vasopressin; aquaporin; collecting duct; volume regulation Address for reprint requests and other correspondence: V. Vallon, Depts. of Medicine and Pharmacology, Univ. of California and VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161 (e-mail: vvallon@ucsd.edu ) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Renal Physiology The American Physiological Society

P2 receptors in the regulation of renal transport mechanisms

Vallon, Volker
AJP - Renal Physiology , Volume 294 (1): F10 – Jan 1, 2008
Download PDF
19 pages

Loading next page...
 
/lp/the-american-physiological-society/p2-receptors-in-the-regulation-of-renal-transport-mechanisms-0PNpzLeM0E

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0363-6127
eISSN
1522-1466
DOI
10.1152/ajprenal.00432.2007
pmid
17977905
Publisher site
See Article on Publisher Site

Abstract

Extracellular nucleotides (e.g., ATP) regulate physiological and pathophysiological processes through activation of nucleotide P2 receptors in the plasma membrane. Examples include such diverse processes as communication from taste buds to gustatory nerves, platelet aggregation, nociception, or neutrophil chemotaxis. Over approximately the last 15 years, evidence has also accumulated that cells in renal epithelia release nucleotides in response to physiological stimuli and that these nucleotides act in a paracrine and autocrine way to activate P2 receptors and play a significant role in the regulation of transport mechanisms and cell volume regulation. This review discusses potential stimuli and mechanisms involved in nucleotide release in renal epithelia and summarizes the available data on the expression and function of nucleotide P2 receptors along the native mammalian tubular and collecting duct system. Using established agonist profiles for P2 receptor subtypes, significant insights have been gained particularly into a potential role for P2Y 2 -like receptors in the regulation of transport mechanisms in the collecting duct. Due to the lack of receptor subtype-specific antagonists, however, the in vivo relevance of P2 receptor subtypes is unclear. Studies in gene knockout mice provided first insights including an antihypertensive activity of P2Y 2 receptors that is linked to an inhibitory influence on renal Na + and water reabsorption. We are only beginning to unravel the important roles of extracellular nucleotides and P2 receptors in the regulation of the diverse transport mechanisms of the kidney. kidney; ATP; UTP; vasopressin; aquaporin; collecting duct; volume regulation Address for reprint requests and other correspondence: V. Vallon, Depts. of Medicine and Pharmacology, Univ. of California and VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161 (e-mail: vvallon@ucsd.edu )

Journal

AJP - Renal Physiology – The American Physiological Society

Published: Jan 1, 2008

There are no references for this article.