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Polymorphism - integrated approach from high-throughput screening to crystallization optimization

Polymorphism - integrated approach from high-throughput screening to crystallization optimization Crystal structure (polymorphism) as well as crystal shape (morphology) and size have a huge practical and commercial impact on active substances all the way from research to manufacture of the final product. For an optimal development process, it is important to have an integrated approach to these issues ranging from a systematic polymorphism screening to a controlled scale-up of the crystallization process. The polymorphism program has to be tailored according to the development stage. Particularly suitable for an early development stage is a high-throughput polymorphism screening, which is the basis for a more thorough investigation if the product proceeds further in development. Such a comprehensive polymorphism investigation involves further crystallization experiments and extensive physicochemical characterization of the various forms. In this article the high-throughput polymorphism screening method that we have developed is described. Using carbamazepine as an example, the power of this high-throughput polymorphism screening system is demonstrated. Not only were all published forms found, but also new forms were identified. In the second part of the article, important considerations for crystallization optimization are discussed, again using the example of carbamazepine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thermal Analysis and Calorimetry Springer Journals

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References (25)

Publisher
Springer Journals
Copyright
Copyright © 2003 by Kluwer Academic Publishers/Akadémiai Kiadó
Subject
Chemistry; Inorganic Chemistry; Physical Chemistry; Polymer Sciences; Measurement Science, Instrumentation
ISSN
1388-6150
eISSN
1572-8943
DOI
10.1023/A:1025409608944
Publisher site
See Article on Publisher Site

Abstract

Crystal structure (polymorphism) as well as crystal shape (morphology) and size have a huge practical and commercial impact on active substances all the way from research to manufacture of the final product. For an optimal development process, it is important to have an integrated approach to these issues ranging from a systematic polymorphism screening to a controlled scale-up of the crystallization process. The polymorphism program has to be tailored according to the development stage. Particularly suitable for an early development stage is a high-throughput polymorphism screening, which is the basis for a more thorough investigation if the product proceeds further in development. Such a comprehensive polymorphism investigation involves further crystallization experiments and extensive physicochemical characterization of the various forms. In this article the high-throughput polymorphism screening method that we have developed is described. Using carbamazepine as an example, the power of this high-throughput polymorphism screening system is demonstrated. Not only were all published forms found, but also new forms were identified. In the second part of the article, important considerations for crystallization optimization are discussed, again using the example of carbamazepine.

Journal

Journal of Thermal Analysis and CalorimetrySpringer Journals

Published: Aug 1, 2003

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