Therapeutic Drug Monitoring in Rheumatic Diseases

Therapeutic Drug Monitoring in Rheumatic Diseases AbstractThe ultimate goal of treating rheumatic disease is to achieve rapid suppression of inflammation, while at the same time minimizing the toxicities from rheumatic drugs. Different patients have different individual pharmacokinetics that can affect the drug level. Moreover, different factors, such as renal function, age or even different underlying diseases, can affect the drug level. Therefore, giving the same dosage of drugs to different patients may result in different drug levels. This article will review the usefulness of therapeutic drug monitoring in maximizing drug efficacy, while reducing the risk of toxicities in Hydroxychloroquine, Mycophenolate Mofetil, Tacrolimus and Tumor Necrosis Factor inhibitors (TNF Inhibitors). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hong Kong Bulletin on Rheumatic Diseases de Gruyter

Therapeutic Drug Monitoring in Rheumatic Diseases

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Publisher
Sciendo
Copyright
© 2016 Alexandra NG Hoi-Yan, Chi Chiu Mok, published by Sciendo
eISSN
2415-153X
D.O.I.
10.1515/hkbrd-2016-0009
Publisher site
See Article on Publisher Site

Abstract

AbstractThe ultimate goal of treating rheumatic disease is to achieve rapid suppression of inflammation, while at the same time minimizing the toxicities from rheumatic drugs. Different patients have different individual pharmacokinetics that can affect the drug level. Moreover, different factors, such as renal function, age or even different underlying diseases, can affect the drug level. Therefore, giving the same dosage of drugs to different patients may result in different drug levels. This article will review the usefulness of therapeutic drug monitoring in maximizing drug efficacy, while reducing the risk of toxicities in Hydroxychloroquine, Mycophenolate Mofetil, Tacrolimus and Tumor Necrosis Factor inhibitors (TNF Inhibitors).

Journal

Hong Kong Bulletin on Rheumatic Diseasesde Gruyter

Published: Dec 30, 2016

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