In this issue of the Scandinavian Journal of Pain, Scaramozzino et al.  present percentile normative values of nociceptive withdrawal reflex and pain thresholds to different electrical stimulation paradigms. The authors suggest that percentiles from a distribution of electrical pain and reflex thresholds from pain-free subjects could be used to detect central hyper- and hyposensitivity in individual patients.1Distribution of thresholdsPain and reflex thresholds from single and repeated electrical stimulation in 300 pain-free subjects were recorded. Summary statistics as well as multivariable analyses identifying important covariates have been published previously based on the same sample . Age was shown to have a statistically significant effect on the subjective pain threshold. The reflex threshold was statistically significantly associated with body-side (dominant or not). No differences between men and women were found.The purpose of this follow-up analysis is to provide estimates of critical normative values that can be used in research on mechanism based chronic pain treatment as well as in clinical practice for assessment of widespread hypersensitivity and hyposensitivity in individual patient. Information on the distribution of electrical pain and reflex thresholds in pain-free volunteers is without doubt of value for pain research. An obvious question is, however, how to define
Scandinavian Journal of Pain – de Gruyter
Published: Apr 1, 2013
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