The swinging pendulum of oesophageal pain—Away from the centre back towards the periphery again

The swinging pendulum of oesophageal pain—Away from the centre back towards the periphery again 1IntroductionArguably one of the great continuing controversies in visceral pain research is whether the pathology that leads to chronic symptoms is largely concentrated in the periphery or in central structures. In this issue of the Scandinavian Journal of Pain, Frøkjær and coworkers [1] report their findings of a case-control study where they sought to delineate the presence or absence of microstructural changes in the central pain neuromatrix of patients with functional chest pain of presumed oesophageal origin (FCP). Using diffusion tensor imaging, they demonstrated that, in a well-defined cohort of functional chest pain patients in the absence of psychological comorbidity, that there were no differences in white matter microstructure. This suggests that the pathophysiology of FCP, in a select group of patients, lies outside these structures. FCP is characterized by recurrent unexplained midline chest pain. The Rome III diagnostic criteria include at least 3 months of symptoms, with onset at least 6 months prior to diagnosis, in the absence of another cause such as oesophageal dysmotility or gastro-oesophageal reflux disease [2]. Despite this criteria, it remains unclear as to whether disorders with similar symptoms, albeit with contrasting nomenclature such as non-cardiac chest pain (NCCP) or syndrome X, represent identical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

The swinging pendulum of oesophageal pain—Away from the centre back towards the periphery again

Loading next page...
 
/lp/degruyter/the-swinging-pendulum-of-oesophageal-pain-away-from-the-centre-back-kWQ6hYro2K
Publisher
De Gruyter
Copyright
© 2014 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2014.01.006
Publisher site
See Article on Publisher Site

Abstract

1IntroductionArguably one of the great continuing controversies in visceral pain research is whether the pathology that leads to chronic symptoms is largely concentrated in the periphery or in central structures. In this issue of the Scandinavian Journal of Pain, Frøkjær and coworkers [1] report their findings of a case-control study where they sought to delineate the presence or absence of microstructural changes in the central pain neuromatrix of patients with functional chest pain of presumed oesophageal origin (FCP). Using diffusion tensor imaging, they demonstrated that, in a well-defined cohort of functional chest pain patients in the absence of psychological comorbidity, that there were no differences in white matter microstructure. This suggests that the pathophysiology of FCP, in a select group of patients, lies outside these structures. FCP is characterized by recurrent unexplained midline chest pain. The Rome III diagnostic criteria include at least 3 months of symptoms, with onset at least 6 months prior to diagnosis, in the absence of another cause such as oesophageal dysmotility or gastro-oesophageal reflux disease [2]. Despite this criteria, it remains unclear as to whether disorders with similar symptoms, albeit with contrasting nomenclature such as non-cardiac chest pain (NCCP) or syndrome X, represent identical

Journal

Scandinavian Journal of Painde Gruyter

Published: Apr 1, 2014

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off