The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased pain intensity and decreased pressure pain thresholds in patients with lumbar radicular pain

The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased pain intensity... 212Abstracts / Scandinavian Journal of Pain 5 (2014) 207–213The interleukin-1␣ gene C>T polymorphismrs1800587 is associated with increased painintensity and decreased pressure painthresholds in patients with lumbar radicularpainElina Iordanova Schistad a,b,∗ , Line MelåJacobsen c , Cecilie Røe a,b , Johannes Gjerstad c,daDepartment of Physical Medicine andRehabilitation, Oslo University Hospital, Ullevål,Norwayb Faculty of Medicine, University of Oslo, Norwayc National Institute of Occupational Health, Oslo,Norwayd Department of Molecular Biosciences, University ofOslo, NorwayAims: Previous studies have suggested that many inflammatorycytokines, including interleukin (IL)-1␣, may be associated withlumbar radicular pain after disc herniation. In the present study, weexamined how variability of the IL-1␣ gene affects pain intensityand the pressure pain threshold (PPT) in patients with symptomaticdisc herniation.Methods: A total of 121 patients with lumbar radicular pain dueto disc herniation were recruited from Oslo University Hospital,Norway, and followed up at 6 weeks and 12 months. The primaryoutcome measures were pain intensity scores for the lower backand legs using a visual analog pain scale (VAS) and PPT for thegluteal muscles. Genotyping was carried out using a predesignedTaqMan assay for IL-1␣ rs1800587. The effect of the IL-1␣ genotypeon the VAS and PPT was analyzed by repeated measure analyses ofvariance.Results: The IL-1␣ gene C>T polymorphism rs1800587 affectedVAS and PPT scores in patients with symptomatic disc herniation.Patients with the CT/TT genotype reported a higher VAS leg painintensity (p = 0.002) and also a lower PPT in the gluteal muscles(left p = 0.016; right p = 0.016) compared to patients with the CCgenotype during 1 year of follow-up.Conclusions: The present data show that the IL-1␣ CT/TT genotype rs1800587 may be associated with increased pain intensity,and corresponding reduced PPT during the first year after disc herniation.E-mail: uxioel@ous-hf.nohttp://dx.doi.org/10.1016/j.sjpain.2014.05.024Levels of N-acylethanolamines in theinterstitium of trapezius muscle during thetissue trauma: A microdialysis study on womenwith chronic widespread painN. Stensson a,∗ , N. Ghafouri a , B. Gerdle a , B.Ghafouri a,baRehabilitation Medicine, Department of Medicineand Health Sciences, Linköping University, SE 581 85Linköping, and Pain and Rehabilitation Centre, UHL,Swedenb County Council of Östergötland, SE 581 85Linköping, SwedenE-mail address: niclas.stensson@liu.se (N. Stensson).Aims: Since the insertion of MD probes causes an acute tissue trauma, analyses of microdialysates during this period haspreviously been disregarded in favour of waiting until stablebaselines are achieved. The aim of this study is to comparethe levels of NAEs in women with chronic widespread pain(CWP) to the healthy controls (CON) during the tissue traumaperiod.Methods: 18 women with CWP were included in this study.Inclusion criteria were female sex, age range 20–65 years, andwidespread pain according to the American College of Rheumatology (ACR) classification. 20 CON were recruited. Inclusioncriteria were female sex age range 20–65 years, and pain-free.All participants were examined by a standard and validatedclinical examination of the upper extremities. MD was conducted in trapezius muscle and dialysate were sampled every20 min, and the samples of interest in this study were collected in the two first hour after catheter insertion. CMA 63(catheter: membrane 30 mm length, 0.5 mm diameter, 20 kDacut-off, flow rate: 5 ␮l/min) was used. The levels of NAEs wereanalyzed by liquid chromatography tandem mass spectrometry(LC–MS/MS).Results: Oleoylethanolamine (OEA) and Palmitoylethanolamine(PEA) levels were significantly higher in CWP compered to CONduring tissue trauma period (Mann–Whitney U-test: P > 0.001 forOEA and P ≤ 0.05 for PEA).Conclusions: Previous biochemical studies of patients withCWP have often focused on sensitizing substances. Here weinvestigated the levels of lipid signaling molecules, with antiinflammatory and pain-relieving properties, during acute tissuetrauma. The results demonstrate that the levels of OEA and PEAdiffer significantly between CWP and CON. A better understandingof the interplay between these lipids and peripheral pain signalingmight provide new therapeutic opportunities for patients withCWP.http://dx.doi.org/10.1016/j.sjpain.2014.05.025Quality pain management in the hospitalsetting—A concept evaluationS. Zoëga a,b,∗ , S. Gunnarsdóttir a,b , D.B. Gordon caLandspítali – The National University Hospital ofIceland, Reykjavík, Icelandb University of Iceland, Reykjavík, Icelandc Department of Anesthesiology & Pain Medicine,University of Washington, Seattle, United StatesAims: To gain an understanding of the concept of quality painmanagement (QPM) in the hospital setting, and to define the concept.Methods: A concept evaluation based on the method by Morseand colleagues was done. The literature was searched according toselected key words in five databases. Over 5000 articles were foundbut data were limited to 37 articles directly related to both qualityand pain management in adults in the hospital setting, and published in peer-reviewed journals or by an official organization. Datawere extracted from these articles and then synthesized accordingto definition, characteristics, boundaries, preconditions, and outcomes of QPM.Results: QPM is a multidimensional concept that is commonlyused but remains vaguely defined. A common understanding ofthe concept is nonetheless evident in the literature. QPM refersto the structure, process, and outcomes of care rooted in equitable, effective, patient-centered, safe, and efficient services. Thestructure encompasses competent staff and staff accountability,organizationally supported evidence-based policies, and accessto interprofessional and specialized care. The process consistsof screening, assessing and reassessing pain, individualized andevidence-based treatment, communication of pain and pain treatment, and patient and family education. Finally, outcomes include http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

The interleukin-1α gene C>T polymorphism rs1800587 is associated with increased pain intensity and decreased pressure pain thresholds in patients with lumbar radicular pain

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De Gruyter
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© 2014 Scandinavian Association for the Study of Pain
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Abstract

212Abstracts / Scandinavian Journal of Pain 5 (2014) 207–213The interleukin-1␣ gene C>T polymorphismrs1800587 is associated with increased painintensity and decreased pressure painthresholds in patients with lumbar radicularpainElina Iordanova Schistad a,b,∗ , Line MelåJacobsen c , Cecilie Røe a,b , Johannes Gjerstad c,daDepartment of Physical Medicine andRehabilitation, Oslo University Hospital, Ullevål,Norwayb Faculty of Medicine, University of Oslo, Norwayc National Institute of Occupational Health, Oslo,Norwayd Department of Molecular Biosciences, University ofOslo, NorwayAims: Previous studies have suggested that many inflammatorycytokines, including interleukin (IL)-1␣, may be associated withlumbar radicular pain after disc herniation. In the present study, weexamined how variability of the IL-1␣ gene affects pain intensityand the pressure pain threshold (PPT) in patients with symptomaticdisc herniation.Methods: A total of 121 patients with lumbar radicular pain dueto disc herniation were recruited from Oslo University Hospital,Norway, and followed up at 6 weeks and 12 months. The primaryoutcome measures were pain intensity scores for the lower backand legs using a visual analog pain scale (VAS) and PPT for thegluteal muscles. Genotyping was carried out using a predesignedTaqMan assay for IL-1␣ rs1800587. The effect of the IL-1␣ genotypeon the VAS and PPT was analyzed by repeated measure analyses ofvariance.Results: The IL-1␣ gene C>T polymorphism rs1800587 affectedVAS and PPT scores in patients with symptomatic disc herniation.Patients with the CT/TT genotype reported a higher VAS leg painintensity (p = 0.002) and also a lower PPT in the gluteal muscles(left p = 0.016; right p = 0.016) compared to patients with the CCgenotype during 1 year of follow-up.Conclusions: The present data show that the IL-1␣ CT/TT genotype rs1800587 may be associated with increased pain intensity,and corresponding reduced PPT during the first year after disc herniation.E-mail: uxioel@ous-hf.nohttp://dx.doi.org/10.1016/j.sjpain.2014.05.024Levels of N-acylethanolamines in theinterstitium of trapezius muscle during thetissue trauma: A microdialysis study on womenwith chronic widespread painN. Stensson a,∗ , N. Ghafouri a , B. Gerdle a , B.Ghafouri a,baRehabilitation Medicine, Department of Medicineand Health Sciences, Linköping University, SE 581 85Linköping, and Pain and Rehabilitation Centre, UHL,Swedenb County Council of Östergötland, SE 581 85Linköping, SwedenE-mail address: niclas.stensson@liu.se (N. Stensson).Aims: Since the insertion of MD probes causes an acute tissue trauma, analyses of microdialysates during this period haspreviously been disregarded in favour of waiting until stablebaselines are achieved. The aim of this study is to comparethe levels of NAEs in women with chronic widespread pain(CWP) to the healthy controls (CON) during the tissue traumaperiod.Methods: 18 women with CWP were included in this study.Inclusion criteria were female sex, age range 20–65 years, andwidespread pain according to the American College of Rheumatology (ACR) classification. 20 CON were recruited. Inclusioncriteria were female sex age range 20–65 years, and pain-free.All participants were examined by a standard and validatedclinical examination of the upper extremities. MD was conducted in trapezius muscle and dialysate were sampled every20 min, and the samples of interest in this study were collected in the two first hour after catheter insertion. CMA 63(catheter: membrane 30 mm length, 0.5 mm diameter, 20 kDacut-off, flow rate: 5 ␮l/min) was used. The levels of NAEs wereanalyzed by liquid chromatography tandem mass spectrometry(LC–MS/MS).Results: Oleoylethanolamine (OEA) and Palmitoylethanolamine(PEA) levels were significantly higher in CWP compered to CONduring tissue trauma period (Mann–Whitney U-test: P > 0.001 forOEA and P ≤ 0.05 for PEA).Conclusions: Previous biochemical studies of patients withCWP have often focused on sensitizing substances. Here weinvestigated the levels of lipid signaling molecules, with antiinflammatory and pain-relieving properties, during acute tissuetrauma. The results demonstrate that the levels of OEA and PEAdiffer significantly between CWP and CON. A better understandingof the interplay between these lipids and peripheral pain signalingmight provide new therapeutic opportunities for patients withCWP.http://dx.doi.org/10.1016/j.sjpain.2014.05.025Quality pain management in the hospitalsetting—A concept evaluationS. Zoëga a,b,∗ , S. Gunnarsdóttir a,b , D.B. Gordon caLandspítali – The National University Hospital ofIceland, Reykjavík, Icelandb University of Iceland, Reykjavík, Icelandc Department of Anesthesiology & Pain Medicine,University of Washington, Seattle, United StatesAims: To gain an understanding of the concept of quality painmanagement (QPM) in the hospital setting, and to define the concept.Methods: A concept evaluation based on the method by Morseand colleagues was done. The literature was searched according toselected key words in five databases. Over 5000 articles were foundbut data were limited to 37 articles directly related to both qualityand pain management in adults in the hospital setting, and published in peer-reviewed journals or by an official organization. Datawere extracted from these articles and then synthesized accordingto definition, characteristics, boundaries, preconditions, and outcomes of QPM.Results: QPM is a multidimensional concept that is commonlyused but remains vaguely defined. A common understanding ofthe concept is nonetheless evident in the literature. QPM refersto the structure, process, and outcomes of care rooted in equitable, effective, patient-centered, safe, and efficient services. Thestructure encompasses competent staff and staff accountability,organizationally supported evidence-based policies, and accessto interprofessional and specialized care. The process consistsof screening, assessing and reassessing pain, individualized andevidence-based treatment, communication of pain and pain treatment, and patient and family education. Finally, outcomes include

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Scandinavian Journal of Painde Gruyter

Published: Dec 29, 2017

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