The effect of serum proteins on apatite growth for 45S5 Bioglass and common sol-gel derived glass in SBF

The effect of serum proteins on apatite growth for 45S5 Bioglass and common sol-gel derived glass... AbstractThe inhibitive effects of serum proteins on apatite growth was compared between melt-derived 45S5 Bioglass® and sol-gel derived bioactive glass of the 70S30C (70 mol% SiO2, 30 mol% CaO). By using techniques of XRD, TEM and Raman spectroscopy, the transformation of amorphous calcium phosphate to crystalline apatite, and the resulting size and aspect ratio of the crystals, in simulated body fluid (SBF), was seen to decrease in the presence of serum. XRD showed more rapid HA formation on Bioglass particles, compared to that forming on 70S30C particles, however TEM showed similar size and frequency of the needle-like crystals. Phosphate reduction in SBF was similar for Bioglass and 70S30C. Calcium carbonate formation was more likely on the phosphate-free sol-gel glass than on Bioglass. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomedical Glasses de Gruyter

The effect of serum proteins on apatite growth for 45S5 Bioglass and common sol-gel derived glass in SBF

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Publisher
De Gruyter Open
Copyright
© 2018
eISSN
2299-3932
D.O.I.
10.1515/bglass-2018-0002
Publisher site
See Article on Publisher Site

Abstract

AbstractThe inhibitive effects of serum proteins on apatite growth was compared between melt-derived 45S5 Bioglass® and sol-gel derived bioactive glass of the 70S30C (70 mol% SiO2, 30 mol% CaO). By using techniques of XRD, TEM and Raman spectroscopy, the transformation of amorphous calcium phosphate to crystalline apatite, and the resulting size and aspect ratio of the crystals, in simulated body fluid (SBF), was seen to decrease in the presence of serum. XRD showed more rapid HA formation on Bioglass particles, compared to that forming on 70S30C particles, however TEM showed similar size and frequency of the needle-like crystals. Phosphate reduction in SBF was similar for Bioglass and 70S30C. Calcium carbonate formation was more likely on the phosphate-free sol-gel glass than on Bioglass.

Journal

Biomedical Glassesde Gruyter

Published: Feb 2, 2018

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