In this issue of the Scandinavian Journal of Pain, Flavia Karine Rigo and co-workers in Brazil report on their studies that revealed a cholinergic mechanism of the antinociceptive action of a peptide from a spider-toxin . Their study is well done and well reported, following the ARRIVE-recommendations for doing and reporting animal research . They found that in a chronic nerve/nerve-root constriction model (model of neuropathic pain) this peptide causes a robust reduction in mechanical withdrawal (~reduction of neuropathic pain), and in pain caused by paw-injection of capsaicin . The mechanism of this effect was clearly demonstrated to be via inhibiting acetylcholine-esterase (AChE) in the CNS (spinal cord). Being a peptide, they had to inject this peptide intrathecally (IT), directly in to the cerebrospinal fluid (CSF).1More attention needed on benefits of cholinergic drugs and on the negative effects on cognitive functions and pain from anticholinergic drugsWe publish their study-report  also because clinicians need more knowledge and attention to the beneficial effects on cognitive functions and pain by cholinergic drugs, but even more so we need more knowledge about the burden of the multitude of anticholinergic drugs. Patients suffering from pain, especially our elderly patients, are often exposed to
Scandinavian Journal of Pain – de Gruyter
Published: Dec 29, 2017
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