In this issue of the Scandinavian Journal of Pain, Yang and co-workers report interesting effects of aloperine on acute and inflammatory pain behaviour in mice . Aloperine is an alkaloid isolated from the plant Sophora alopecuroides L that, as indicated by preclinical evidence, possesses anti-inflammatory and anti-allergic properties . In the Yang and co-workers’ study, aloperine’s analgesic efficacies were determined by performing behavioural tests of acute and inflammatory pain, and the authors documented that aloperine can suppress pain-like behaviours in several inflammatory pain models in mice .In acetic acid-induced writhing test, aloperine (40 mg/kg or 80mg/kg) had an anti-nociceptive effect and reduced the writhing behaviours. However, compared with morphine (10 mg/kg), which almost completely inhibited the writhing response, the effects of these doses of aloperine were minor . Similarly, aloperine was found to be able to dose-dependently suppress formalin-induced pain behaviour, both in the first and second phases, while aspirin was only effective in the second phase . Furthermore, the ear swelling test and carrageenan-induced paw oedema test documented aloperine’s suppressing effect on inflammation. In these tests, aloperine was found to suppress the pro-inflammatory cytokines tumour necrosis factor, Interleukin-1 beta, and prostaglandin E2, as well as enhancing the production
Scandinavian Journal of Pain – de Gruyter
Published: Dec 29, 2017
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