Social stress, epigenetic changes and pain

Social stress, epigenetic changes and pain AbstractAimsBullying is a prevalent issue in society, with adverse effects ranging from psychological symptoms to somatic ailments like chronic pain. The purpose of this study was to generate new knowledge about the underlying mechanisms behind this association. Using an animal model, we investigated the changes in microRNA expression in plasma, in the pituitary gland and the adrenal gland following social stress.MethodsA resident-intruder paradigm where male Sprague Dawley rats (intruders) were exposed to male Long Evans rats (resident) 1 h daily for a week was used. Bodyweight was measured and blood samples were collected throughout the experiment. Changes in plasma microRNA expression was determined by qPCR.ResultsRats exposed to social stress showed reduced weight gain compared to controls. Preliminary results suggested that social stress increased the plasma expression of miR-146a-5p, miR-30c- 5p and miR-223-3p.ConclusionsThe data showed that social stress gives reduced weight gain and increased expression of several circulating microRNAs. How this affects the development of persistent pain remains to be investigated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

Social stress, epigenetic changes and pain

Loading next page...
 
/lp/degruyter/social-stress-epigenetic-changes-and-pain-1KGaT0Ob0N
Publisher
De Gruyter
Copyright
© 2017 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2017.04.017
Publisher site
See Article on Publisher Site

Abstract

AbstractAimsBullying is a prevalent issue in society, with adverse effects ranging from psychological symptoms to somatic ailments like chronic pain. The purpose of this study was to generate new knowledge about the underlying mechanisms behind this association. Using an animal model, we investigated the changes in microRNA expression in plasma, in the pituitary gland and the adrenal gland following social stress.MethodsA resident-intruder paradigm where male Sprague Dawley rats (intruders) were exposed to male Long Evans rats (resident) 1 h daily for a week was used. Bodyweight was measured and blood samples were collected throughout the experiment. Changes in plasma microRNA expression was determined by qPCR.ResultsRats exposed to social stress showed reduced weight gain compared to controls. Preliminary results suggested that social stress increased the plasma expression of miR-146a-5p, miR-30c- 5p and miR-223-3p.ConclusionsThe data showed that social stress gives reduced weight gain and increased expression of several circulating microRNAs. How this affects the development of persistent pain remains to be investigated.

Journal

Scandinavian Journal of Painde Gruyter

Published: Dec 29, 2017

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off