AbstractAimsBullying is a prevalent issue in society, with adverse effects ranging from psychological symptoms to somatic ailments like chronic pain. The purpose of this study was to generate new knowledge about the underlying mechanisms behind this association. Using an animal model, we investigated the changes in microRNA expression in plasma, in the pituitary gland and the adrenal gland following social stress.MethodsA resident-intruder paradigm where male Sprague Dawley rats (intruders) were exposed to male Long Evans rats (resident) 1 h daily for a week was used. Bodyweight was measured and blood samples were collected throughout the experiment. Changes in plasma microRNA expression was determined by qPCR.ResultsRats exposed to social stress showed reduced weight gain compared to controls. Preliminary results suggested that social stress increased the plasma expression of miR-146a-5p, miR-30c- 5p and miR-223-3p.ConclusionsThe data showed that social stress gives reduced weight gain and increased expression of several circulating microRNAs. How this affects the development of persistent pain remains to be investigated.
Scandinavian Journal of Pain – de Gruyter
Published: Dec 29, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera