Sinomenine against neuropathic pain hypersensitivity

Sinomenine against neuropathic pain hypersensitivity An alkaloid extracted from the plant Sinomenium acutum has been used for treating rheumatoid arthritis in the Far East. Earlier studies suggest that sinomenine has anti-inflammatory actions and also mild sedative and analgesic actions [1, 2, 3]. It is still not clear through which mechanisms sinomenine induces its analgesic action. Concerning the potential role of opioid receptors, there is a study suggesting that sinomenine activates opioid μ-receptors as revealed by an in vitro binding assay and that the sinomenine-induced heat-antinociception is reversed by an opioid receptor antagonist naloxonazine [4]. However, recently a more extensive study demonstrated that sinomenine attenuated pain behaviour in experimental models of neuropathic and inflammatory pain as well as in controls and that opioid receptor antagonist nalox-one did not reverse the sinomenine-induced antinociception [5]. Among alternative explanations for the sinomenine-induced analgesic actions is the block of an acid-sensing ion channel and the L-type calcium channel [6]. Both of these effects might reduce activation of neurons carrying pain-related signals. On the other hand, a recent study in an experimental model of neuropathy showed that the sinomenine-induced attenuation of pain behaviour was associated with a modulation of striatal monoamine release suggesting that monoaminergic mechanisms might contribute to the sinomenine-induced analgesia [7]. Among other mechanisms possibly contributing to the sinomenine-induced attenuation of pain behaviour are a potential block of NMDA receptors [5] and/or reduced production of proinflammatory cytokines [8,9], reactive oxygen species [9,10] and matrix metalloproteinases [11].While earlier studies still leave open the mechanisms underlying the pain suppressive effect of sinomenine, the finding that its acute administration is effective against inflammatory and neuropathic pain hypersensitivity, without obvious side-effects, indicates that it is worthwhile to study in more detail effects of sinomenine in various pain conditions. Concerning treatment of chronic pain, one important question to be asked is whether repeated sinomenine administration leads to tolerance. This question was addressed by Gao and coworkers in their recent study published in this issue [12]. They used two experimental rodent models of chronic neuropathic pain to assess the effect of repeated sinomenine administration. Their main finding is that systemic administration of sinomenine twice daily produced an enhanced antiallodynic effect. The antiallodynic response persisted for days after the termination of 5 day treatment. Importantly the authors found no signs of tolerance, and no obvious side-effects. Moreover, an opioid receptor antagonist failed to reverse the sinomenine-induced antiallodynic effect confirming the interpretation that the attenuation of pain behaviour was not due to sinomenine-induced action on opioid receptors. Together with earlier findings, these findings by Gao and coworkers [12] support the proposal that sinomenine is a promising candidate to be further studied in the treatment of chronic pain conditions.[1]Yamasaki H. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med Okayama 1976;30:1–20.61710Yamasaki H Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum Acta Med Okayama 197630120[2]Xu M, Liu L, Qi C, Deng B, Cai X. Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Planta Med 2008;74:1423–9.18683125http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000260253600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1055/s-2008-1081346Xu M Liu L Qi C Deng B Cai X Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis Planta Med 20087414239[3]Wang Q, Li XK. Immunosuppressive and anti-inflammatory activities of sinomenine. Int Immunopharmacol 2011;11:373–6.10.1016/j.intimp.2010.11.01821109035http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000288636400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Wang Q Li XK Immunosuppressive and anti-inflammatory activities of sinomenine Int Immunopharmacol 2011113736[4]Wang MH, Chang CK, Cheng JH, Wu HT, Li YX, Cheng JT. Activation of opioid (x-receptor by sinomenine in cell and mice. Neurosci Lett 2008;443:209–12.10.1016/j.neulet.2008.07.088http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259849800020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Wang MH Chang CK Cheng JH Wu HT Li YX Cheng JT Activation of opioid (x-receptor by sinomenine in cell and mice Neurosci Lett 200844320912[5]Gao T, Hao J, Wiesenfeld-Hallin Z, Wang DQ, Xu XJ. Analgesic effect of sinomenine in rodents after inflammation and nerve injury. Eur J Pharmacol 2013;721:5–11.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327541600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f32412036910.1016/j.ejphar.2013.09.062Gao T Hao J Wiesenfeld-Hallin Z Wang DQ Xu XJ Analgesic effect of sinomenine in rodents after inflammation and nerve injury Eur J Pharmacol 2013721511[6]Wu WN, Wu PF, Chen XL, Zhang Z, Gu J, Yang YJ, Xiong QJ, Ni L, Wang F, Chen JG. Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels. Br J Pharmacol 2011;164:1445–59.10.1111/j.1476-5381.2011.01487.xhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296472300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f321585344Wu WN Wu PF Chen XL Zhang Z Gu J Yang YJ Xiong QJ Ni L Wang F Chen JG Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels Br J Pharmacol 2011164144559[7]Zhang MY, Li P, Wang DQ, Niu XH, Wang Y, Wang ZG, Zhang Y, Xu S, Xu XJ. [Analgesic effect of sinomenine on SSNI model rats and monoamine neu-rotransmitters in striatal extracellular fluid]. Zhongguo Zhong Yao Za Zhi 2013;38:597–604.23713290Zhang MY Li P Wang DQ Niu XH Wang Y Wang ZG Zhang Y Xu S Xu XJ [Analgesic effect of sinomenine on SSNI model rats and monoamine neu-rotransmitters in striatal extracellular fluid] Zhongguo Zhong Yao Za Zhi 201338597604[8]Wang Y, Fang Y, Huang W, Zhou X, Wang M, Zhong B, Peng D. Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats. J Ethnopharmacol 2005;98:37–43.10.1016/j.jep.2004.12.02215763362Wang Y Fang Y Huang W Zhou X Wang M Zhong B Peng D Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats J Ethnopharmacol 2005983743[9]Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM. Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation 2007;4:23.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000250873200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1186/1742-2094-4-2317880684Qian L Xu Z Zhang W Wilson B Hong JS Flood PM Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase J Neuroinflammation 2007423[10]Yang Z, Liu Y, Yuan F, Li Z, Huang S, Shen H, Yuan B. Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage. Mol Immunol 2014;60:109–14.24815539http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337883700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1016/j.molimm.2014.03.005Yang Z Liu Y Yuan F Li Z Huang S Shen H Yuan B Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage Mol Immunol 20146010914[11]Zhou H, Wong YF, Wang J, Cai X, Liu L. Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats. Biochem Biophys Res Commun 2008;376:352–7.10.1016/j.bbrc.2008.08.15318782565http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000260197200021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Zhou H Wong YF Wang J Cai X Liu L Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats Biochem Biophys Res Commun 20083763527[12]Gao T, Shi T, Wang DQ, Wiesenfeld-Hallin Z, Xu XJ. Repeated sinomenine administration alleviates chronic neuropathic pain-like behaviours in rodents without producing tolerance. ScandJ Pain 2014;5:249–55.Gao T Shi T Wang DQ Wiesenfeld-Hallin Z Xu XJ Repeated sinomenine administration alleviates chronic neuropathic pain-like behaviours in rodents without producing tolerance ScandJ Pain 2014524955 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

Sinomenine against neuropathic pain hypersensitivity

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de Gruyter
Copyright
© 2014 Scandinavian Association for the Study of Pain
ISSN
1877-8860
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1877-8879
D.O.I.
10.1016/j.sjpain.2014.08.002
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Abstract

An alkaloid extracted from the plant Sinomenium acutum has been used for treating rheumatoid arthritis in the Far East. Earlier studies suggest that sinomenine has anti-inflammatory actions and also mild sedative and analgesic actions [1, 2, 3]. It is still not clear through which mechanisms sinomenine induces its analgesic action. Concerning the potential role of opioid receptors, there is a study suggesting that sinomenine activates opioid μ-receptors as revealed by an in vitro binding assay and that the sinomenine-induced heat-antinociception is reversed by an opioid receptor antagonist naloxonazine [4]. However, recently a more extensive study demonstrated that sinomenine attenuated pain behaviour in experimental models of neuropathic and inflammatory pain as well as in controls and that opioid receptor antagonist nalox-one did not reverse the sinomenine-induced antinociception [5]. Among alternative explanations for the sinomenine-induced analgesic actions is the block of an acid-sensing ion channel and the L-type calcium channel [6]. Both of these effects might reduce activation of neurons carrying pain-related signals. On the other hand, a recent study in an experimental model of neuropathy showed that the sinomenine-induced attenuation of pain behaviour was associated with a modulation of striatal monoamine release suggesting that monoaminergic mechanisms might contribute to the sinomenine-induced analgesia [7]. Among other mechanisms possibly contributing to the sinomenine-induced attenuation of pain behaviour are a potential block of NMDA receptors [5] and/or reduced production of proinflammatory cytokines [8,9], reactive oxygen species [9,10] and matrix metalloproteinases [11].While earlier studies still leave open the mechanisms underlying the pain suppressive effect of sinomenine, the finding that its acute administration is effective against inflammatory and neuropathic pain hypersensitivity, without obvious side-effects, indicates that it is worthwhile to study in more detail effects of sinomenine in various pain conditions. Concerning treatment of chronic pain, one important question to be asked is whether repeated sinomenine administration leads to tolerance. This question was addressed by Gao and coworkers in their recent study published in this issue [12]. They used two experimental rodent models of chronic neuropathic pain to assess the effect of repeated sinomenine administration. Their main finding is that systemic administration of sinomenine twice daily produced an enhanced antiallodynic effect. The antiallodynic response persisted for days after the termination of 5 day treatment. Importantly the authors found no signs of tolerance, and no obvious side-effects. Moreover, an opioid receptor antagonist failed to reverse the sinomenine-induced antiallodynic effect confirming the interpretation that the attenuation of pain behaviour was not due to sinomenine-induced action on opioid receptors. Together with earlier findings, these findings by Gao and coworkers [12] support the proposal that sinomenine is a promising candidate to be further studied in the treatment of chronic pain conditions.[1]Yamasaki H. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med Okayama 1976;30:1–20.61710Yamasaki H Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum Acta Med Okayama 197630120[2]Xu M, Liu L, Qi C, Deng B, Cai X. Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Planta Med 2008;74:1423–9.18683125http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000260253600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1055/s-2008-1081346Xu M Liu L Qi C Deng B Cai X Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis Planta Med 20087414239[3]Wang Q, Li XK. Immunosuppressive and anti-inflammatory activities of sinomenine. Int Immunopharmacol 2011;11:373–6.10.1016/j.intimp.2010.11.01821109035http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000288636400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Wang Q Li XK Immunosuppressive and anti-inflammatory activities of sinomenine Int Immunopharmacol 2011113736[4]Wang MH, Chang CK, Cheng JH, Wu HT, Li YX, Cheng JT. Activation of opioid (x-receptor by sinomenine in cell and mice. Neurosci Lett 2008;443:209–12.10.1016/j.neulet.2008.07.088http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259849800020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Wang MH Chang CK Cheng JH Wu HT Li YX Cheng JT Activation of opioid (x-receptor by sinomenine in cell and mice Neurosci Lett 200844320912[5]Gao T, Hao J, Wiesenfeld-Hallin Z, Wang DQ, Xu XJ. Analgesic effect of sinomenine in rodents after inflammation and nerve injury. Eur J Pharmacol 2013;721:5–11.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327541600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f32412036910.1016/j.ejphar.2013.09.062Gao T Hao J Wiesenfeld-Hallin Z Wang DQ Xu XJ Analgesic effect of sinomenine in rodents after inflammation and nerve injury Eur J Pharmacol 2013721511[6]Wu WN, Wu PF, Chen XL, Zhang Z, Gu J, Yang YJ, Xiong QJ, Ni L, Wang F, Chen JG. Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels. Br J Pharmacol 2011;164:1445–59.10.1111/j.1476-5381.2011.01487.xhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296472300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f321585344Wu WN Wu PF Chen XL Zhang Z Gu J Yang YJ Xiong QJ Ni L Wang F Chen JG Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels Br J Pharmacol 2011164144559[7]Zhang MY, Li P, Wang DQ, Niu XH, Wang Y, Wang ZG, Zhang Y, Xu S, Xu XJ. [Analgesic effect of sinomenine on SSNI model rats and monoamine neu-rotransmitters in striatal extracellular fluid]. Zhongguo Zhong Yao Za Zhi 2013;38:597–604.23713290Zhang MY Li P Wang DQ Niu XH Wang Y Wang ZG Zhang Y Xu S Xu XJ [Analgesic effect of sinomenine on SSNI model rats and monoamine neu-rotransmitters in striatal extracellular fluid] Zhongguo Zhong Yao Za Zhi 201338597604[8]Wang Y, Fang Y, Huang W, Zhou X, Wang M, Zhong B, Peng D. Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats. J Ethnopharmacol 2005;98:37–43.10.1016/j.jep.2004.12.02215763362Wang Y Fang Y Huang W Zhou X Wang M Zhong B Peng D Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats J Ethnopharmacol 2005983743[9]Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM. Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation 2007;4:23.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000250873200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1186/1742-2094-4-2317880684Qian L Xu Z Zhang W Wilson B Hong JS Flood PM Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase J Neuroinflammation 2007423[10]Yang Z, Liu Y, Yuan F, Li Z, Huang S, Shen H, Yuan B. Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage. Mol Immunol 2014;60:109–14.24815539http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337883700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f310.1016/j.molimm.2014.03.005Yang Z Liu Y Yuan F Li Z Huang S Shen H Yuan B Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage Mol Immunol 20146010914[11]Zhou H, Wong YF, Wang J, Cai X, Liu L. Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats. Biochem Biophys Res Commun 2008;376:352–7.10.1016/j.bbrc.2008.08.15318782565http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000260197200021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=b7bc2757938ac7a7a821505f8243d9f3Zhou H Wong YF Wang J Cai X Liu L Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats Biochem Biophys Res Commun 20083763527[12]Gao T, Shi T, Wang DQ, Wiesenfeld-Hallin Z, Xu XJ. Repeated sinomenine administration alleviates chronic neuropathic pain-like behaviours in rodents without producing tolerance. ScandJ Pain 2014;5:249–55.Gao T Shi T Wang DQ Wiesenfeld-Hallin Z Xu XJ Repeated sinomenine administration alleviates chronic neuropathic pain-like behaviours in rodents without producing tolerance ScandJ Pain 2014524955

Journal

Scandinavian Journal of Painde Gruyter

Published: Oct 1, 2014

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