Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo... AbstractThe microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called “prion-like” manner. A number of steps are assumed to be involved in this process, including secretion, cellular uptake, transcellular transfer and/or seeding, although the precise mechanisms underlying propagation of Tau pathology are not fully understood yet. This review summarizes recent evidence on the nature of the specific Tau species that are propagated and the different mechanisms of Tau pathology spreading. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomolecular Concepts de Gruyter

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro

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Publisher
De Gruyter Open
Copyright
© 2018 Walter de Gruyter GmbH, Berlin/Boston
ISSN
1868-503X
eISSN
1868-503X
D.O.I.
10.1515/bmc-2018-0001
Publisher site
See Article on Publisher Site

Abstract

AbstractThe microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called “prion-like” manner. A number of steps are assumed to be involved in this process, including secretion, cellular uptake, transcellular transfer and/or seeding, although the precise mechanisms underlying propagation of Tau pathology are not fully understood yet. This review summarizes recent evidence on the nature of the specific Tau species that are propagated and the different mechanisms of Tau pathology spreading.

Journal

Biomolecular Conceptsde Gruyter

Published: Mar 5, 2018

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