In this issue of the Scandinavian Journal of Pain, Katja Venborg Pedersen and coworkers  present an interesting study evaluating the influence of unilateral painful visceral disease on sensory and morphometric changes in the referred pain area. Twenty-four patients with unilateral pain from kidney stone disease were studied before and after endoscopic percutaneous kidney stone surgery. These patients had suffered from the stone disease in median 7 months, and 9 of the patients had experienced 10 or more episodes of painful stone colics. Sensory assessments included electrical and mechanical stimuli, and morphometric analyses were by CT-and ultrasound-scans. The authors did not observe any differences between the ipsilateral and contralateral flanks, in regard to pain threshold, temporal summation, or tissue volume. This is a well-performed study that contradicts results of several comparable studies. The authors also deserve much credit for presenting skillfully, balanced arguments for this discrepancy. We will shortly return to this issue.1Are negative studies unsexy, not interesting and not worthy of publication?Based on the many negative findings of the study, a provocative discussion is offered: should studies with non-significant findings be published or not? Thirteen comparisons were made in this study, 10 of these were non-significant. Studies rejecting
Scandinavian Journal of Pain – de Gruyter
Published: Jul 1, 2013
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