1IntroductionIn this issue of the Scandinavian Journal of Pain, Juerg Schliess-bach and coworkers  report the findings in several quantitative sensory tests (QST) assessing nociception compared to clinical treatment effect in 50 chronic low-back pain patients randomized to receive oxycodone or placebo in a double-blind RCT with crossover design. Acute anti-nociceptive QST effects of oxycodone were assessed against its clinical analgesic efficacy, with special emphasis on the ability of QST findings to predict and differentiate clinical responders from non-responders. This is a novel approach to utilize QST measures in a relevant clinical setting, which might prove useful for future preclinical and clinical trials on analgesic drugs.2Difficult task of assessing pain and measuring analgesiaPain is a multifaceted subjective experience, which cannot be assessed with external objective measures nor easily be reduced to one-dimensional figures. Both in clinical research and practice, analgesic treatment efficacy is evaluated with subjective symptom severity scales whereas experimental preclinical studies apply different QST measures. Due to differences in these testing algorithms, there is disappointingly often a mismatch between promising pre-clinical but failing clinical outcomes for novel drugs. This might be improved by validating and assessing the predictive value of antinociceptive QST alterations against clinical analgesic efficacy
Scandinavian Journal of Pain – de Gruyter
Published: Dec 29, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera