In this number of the Scandinavian Journal of Pain, Ulrika Heddini et al.  observed that single nucleotide polymorphism (SNP) variability in the OPRM1 A118G (rs1799971) was related to chronic pain from vestibulodynia. The same A-allele in the OPRM1 A118G that increased risk for vestibulodynia was also related to higher experimental pain sensitivity. Women with vestibulodynia also had higher levels of plasma concentrations of the endogenous opioid beta-endorphin. Thus, in this study the evidence suggest that the G allele should protect against this sort of chronic pain.1OPRM1 A118G in experimental studiesThe influence from genetic variability on pain perception and opioid efficacy is not to be disputed. Common clinical experience is that patients vary, and state of the art twin studies have demonstrated the inheritability of both pain perception and opioid efficacy [2,3]. Obviously, the gene coding for the OPRM1 receptor is one of the candidate genes for pain and opioid efficacy. The most studied of the 43 SNPs identified by Hoehe et al. within the OPRM1 gene is the OPRM1 A118G . This SNP altered experimental effects from beta-endorphin , and early human experimental studies by Lotsch et al.  showed that subjects carrying one or two copies of
Scandinavian Journal of Pain – de Gruyter
Published: Dec 29, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera