In this number of the Scandinavian Journal of Pain, Ulrika Heddini et al.  observed that single nucleotide polymorphism (SNP) variability in the OPRM1 A118G (rs1799971) was related to chronic pain from vestibulodynia. The same A-allele in the OPRM1 A118G that increased risk for vestibulodynia was also related to higher experimental pain sensitivity. Women with vestibulodynia also had higher levels of plasma concentrations of the endogenous opioid beta-endorphin. Thus, in this study the evidence suggest that the G allele should protect against this sort of chronic pain.1OPRM1 A118G in experimental studiesThe influence from genetic variability on pain perception and opioid efficacy is not to be disputed. Common clinical experience is that patients vary, and state of the art twin studies have demonstrated the inheritability of both pain perception and opioid efficacy [2,3]. Obviously, the gene coding for the OPRM1 receptor is one of the candidate genes for pain and opioid efficacy. The most studied of the 43 SNPs identified by Hoehe et al. within the OPRM1 gene is the OPRM1 A118G . This SNP altered experimental effects from beta-endorphin , and early human experimental studies by Lotsch et al.  showed that subjects carrying one or two copies of
Scandinavian Journal of Pain – de Gruyter
Published: Jan 1, 2014
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