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- Publisher
- de Gruyter
- Copyright
- © 2018 Yu Chen et al., published by De Gruyter
- ISSN
- 2391-5463
- eISSN
- 2391-5463
- DOI
- 10.1515/med-2018-0010
- Publisher site
- See Article on Publisher Site
Abstract
AbstractTo evaluate the pharmacoeconomics of three therapeutic schemes in treating anti-tuberluosis therapy -induced liver injury (anti-TB DILI).MethodsIn the construction of a decision tree model, the efficacy and safety parameters came from the results of the randomized, controlled trial conducted here, the effect parameters were derived from expert advice, and the cost parameters, such as usage specification, number, and unit price, came from literature, expert advice, and so on.ResultsThe cost-effectiveness analysis (CEA) based on the effect degrees showed that bicyclol had the best effect (4.63562). The incremental cost-effectiveness ratio (ICER) (206.03270) of bicyclol was the lowest. The cost-effectiveness ratio of silibinin was the lowest (68.59987). The CEA based on the complete normalization rate showed that bicyclol had the highest complete normalization rate (83.562%), the lowest cost-effectiveness ratio (4.63627), and the smallest ICER (4.63504). Sensitivity analyses proved the robustness of the results.ConclusionsBicyclol is the most cost-effective therapy and the preferred choice for treating anti-TB DILI.
Journal
Open Medicine – de Gruyter
Published: Mar 21, 2018
Keywords: Cost-effectiveness analysis; Decision trees analysis; Anti-TB DILI; Pharmacoeconomics; Prospective