Oral immediate and prolonged release oxycodone for safe and effective patient controlled analgesia after surgery Can opioid for acute postoperative pain be improved by adding a peripheral opioid antagonist?

Oral immediate and prolonged release oxycodone for safe and effective patient controlled... In this issue of the Scandinavian Journal of Pain Boel Niklasson and co-workers, report a pragmatic study on pain relief in patients after Caesarean Section (CS). They compared a regimen with oral immediate and prolonged release oxycodone with the standard of care at Karolinska University Hospital, Huddinge [1]. Standard of care at the time at Huddinge was intravenous (IV) morphine administered by nurses during the first 24 h after a CS and thereafter with codeine-containing tablets. Both groups received ibuprofen and paracetamol.1Pragmatic clinical studies and explanatory clinical studiesA pragmatic study seeks to find the best way to treat patients in a specific clinical situation, whereas an explanatory study seeks to find a causal relationship that has general validity outside the particular clinical situation being studied [2]. A pragmatic study like the present study [1], in which patients and those treating the patients and evaluating the outcomes were not blinded, will have a number of confounding factors, and the results may not be valid for other populations in other circumstances [2]. However, a pragmatic study can document that a new regimen of pain management is at least as effective and safe as the standard of care therapy used before. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

Oral immediate and prolonged release oxycodone for safe and effective patient controlled analgesia after surgery Can opioid for acute postoperative pain be improved by adding a peripheral opioid antagonist?

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Publisher
De Gruyter
Copyright
© 2015 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2015.01.007
Publisher site
See Article on Publisher Site

Abstract

In this issue of the Scandinavian Journal of Pain Boel Niklasson and co-workers, report a pragmatic study on pain relief in patients after Caesarean Section (CS). They compared a regimen with oral immediate and prolonged release oxycodone with the standard of care at Karolinska University Hospital, Huddinge [1]. Standard of care at the time at Huddinge was intravenous (IV) morphine administered by nurses during the first 24 h after a CS and thereafter with codeine-containing tablets. Both groups received ibuprofen and paracetamol.1Pragmatic clinical studies and explanatory clinical studiesA pragmatic study seeks to find the best way to treat patients in a specific clinical situation, whereas an explanatory study seeks to find a causal relationship that has general validity outside the particular clinical situation being studied [2]. A pragmatic study like the present study [1], in which patients and those treating the patients and evaluating the outcomes were not blinded, will have a number of confounding factors, and the results may not be valid for other populations in other circumstances [2]. However, a pragmatic study can document that a new regimen of pain management is at least as effective and safe as the standard of care therapy used before. The

Journal

Scandinavian Journal of Painde Gruyter

Published: Dec 29, 2017

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