In this issue of the Scandinavian Journal of Pain Boel Niklasson and co-workers, report a pragmatic study on pain relief in patients after Caesarean Section (CS). They compared a regimen with oral immediate and prolonged release oxycodone with the standard of care at Karolinska University Hospital, Huddinge . Standard of care at the time at Huddinge was intravenous (IV) morphine administered by nurses during the first 24 h after a CS and thereafter with codeine-containing tablets. Both groups received ibuprofen and paracetamol.1Pragmatic clinical studies and explanatory clinical studiesA pragmatic study seeks to find the best way to treat patients in a specific clinical situation, whereas an explanatory study seeks to find a causal relationship that has general validity outside the particular clinical situation being studied . A pragmatic study like the present study , in which patients and those treating the patients and evaluating the outcomes were not blinded, will have a number of confounding factors, and the results may not be valid for other populations in other circumstances . However, a pragmatic study can document that a new regimen of pain management is at least as effective and safe as the standard of care therapy used before. The
Scandinavian Journal of Pain – de Gruyter
Published: Apr 1, 2015
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