NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for diclofenac, ibuprofen, naproxen, and celecoxib: what are the alternatives?

NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for... Citing the excellent editorial comment by Pekka Mäntyselkä 10 years ago in PAIN on the “Balancing act with geriatric pain treatment”, World Health Organisation predicts that there will be 1.2 billion people above 60 years by 2025, 2 billion by 2050, and in the developed world the very old, aged 80+, is the fastest growing population group. Persistent pain, due to degenerative diseases, osteoarthritis (OA) in particular, becomes more prevalent as a person ages [1]. Comorbidities and polypharmacies increasingly pose dilemmas with increasing risks of interactions and serious side effects. Pain and dysfunction from OA are poorly relieved [2], but NSAIDs (traditional tNSAIDs and COX-2 specific inhibitors – COX- IBs) are still recommended as cornerstones in the pharmacological treatment of OA [3].In this issue of the Scandinavian Journal of Pain Patricia Guyot and her co-workers with senior author Andrew Moore, publish an interesting network meta-analysis of diclofenac, ibuprofen, naproxen, indomethacine, and piroxicam for osteoarthritis pain [4]. They analyzed data from 29 previously unpublished randomized, controlled (double-blind) trials (RCTs) from the time before the specific COX- 2-inhibitors appeared and before cardiovascular risks of traditional NSAIDs and the COXIBs were recognized.A network meta-analysis is possible when one drug is compare with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for diclofenac, ibuprofen, naproxen, and celecoxib: what are the alternatives?

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Publisher
De Gruyter
Copyright
© 2017 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2017.05.009
Publisher site
See Article on Publisher Site

Abstract

Citing the excellent editorial comment by Pekka Mäntyselkä 10 years ago in PAIN on the “Balancing act with geriatric pain treatment”, World Health Organisation predicts that there will be 1.2 billion people above 60 years by 2025, 2 billion by 2050, and in the developed world the very old, aged 80+, is the fastest growing population group. Persistent pain, due to degenerative diseases, osteoarthritis (OA) in particular, becomes more prevalent as a person ages [1]. Comorbidities and polypharmacies increasingly pose dilemmas with increasing risks of interactions and serious side effects. Pain and dysfunction from OA are poorly relieved [2], but NSAIDs (traditional tNSAIDs and COX-2 specific inhibitors – COX- IBs) are still recommended as cornerstones in the pharmacological treatment of OA [3].In this issue of the Scandinavian Journal of Pain Patricia Guyot and her co-workers with senior author Andrew Moore, publish an interesting network meta-analysis of diclofenac, ibuprofen, naproxen, indomethacine, and piroxicam for osteoarthritis pain [4]. They analyzed data from 29 previously unpublished randomized, controlled (double-blind) trials (RCTs) from the time before the specific COX- 2-inhibitors appeared and before cardiovascular risks of traditional NSAIDs and the COXIBs were recognized.A network meta-analysis is possible when one drug is compare with

Journal

Scandinavian Journal of Painde Gruyter

Published: Jul 1, 2017

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