AbstractA major challenge for understanding our nervous system is to elucidate how its constituting cells coordinate each other to form and maintain a functional organ. The interaction between neurons and oligodendrocytes represents a unique cellular entity. Oligodendrocytes myelinate axons by tightly ensheathing them. Myelination regulates speed of signal transduction, thus communication between neurons, and supports long-term axonal health. Despite their importance, we still have large gaps in our understanding of the mechanisms underlying myelinated axon formation, remodelling and repair. Zebrafish represent an increasingly popular model organism, particularly due to their suitability for live cell imaging and genetic manipulation. Here, we provide an overview about this research area, describe how zebrafish have helped understanding mechanisms of myelination, and discuss how zebrafish may help addressing open questions related to the control of axon-oligodendrocyte interactions.
Neuroforum – de Gruyter
Published: Nov 27, 2017
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