Multi-target treatment of bone cancer pain using synergistic combinations of pharmacological compounds in experimental animals

Multi-target treatment of bone cancer pain using synergistic combinations of pharmacological... In this issue of the Scandinavian Journal of Pain, González- Rodríguez and coworkers report about treatment of bone cancer pain using synergistic combinations of a dual enkephalinase inhibitor with various other drugs in experimental animals [1]. In the clinic, cancer, particularly that originating in the lung, breast and prostate, frequently metastasizes to bone, where it may cause pain, although not in all subjects or at all metastasized sites [2]. Bone cancer-induced pain may progress quickly from intermittent to continuous and further to breakthrough pain with episodes of extreme pain that occur spontaneously or that are induced e.g. by weight-bearing on the tumour-affected bones [3]. Additionally, bone cancer pain can be accompanied by mechanical hypersensitivity, due to which even gentle movements or touching the skin close to the tumour may induce strong pain [4,5]. These bone cancer-induced symptoms can severely reduce quality of life.1Experimental animal models in the study of mechanisms of bone cancer painDevelopment of experimental animal models for the study of bone cancer pain has significantly advanced our understanding of underlying mechanisms. Behaviorally, animal models of bone cancer pain induce in the affected limb guarding and mechanical hypersensitivity mirroring continuous pain and tactile allodynia in the clinic [4]. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

Multi-target treatment of bone cancer pain using synergistic combinations of pharmacological compounds in experimental animals

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Publisher
De Gruyter
Copyright
© 2016 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2016.11.001
Publisher site
See Article on Publisher Site

Abstract

In this issue of the Scandinavian Journal of Pain, González- Rodríguez and coworkers report about treatment of bone cancer pain using synergistic combinations of a dual enkephalinase inhibitor with various other drugs in experimental animals [1]. In the clinic, cancer, particularly that originating in the lung, breast and prostate, frequently metastasizes to bone, where it may cause pain, although not in all subjects or at all metastasized sites [2]. Bone cancer-induced pain may progress quickly from intermittent to continuous and further to breakthrough pain with episodes of extreme pain that occur spontaneously or that are induced e.g. by weight-bearing on the tumour-affected bones [3]. Additionally, bone cancer pain can be accompanied by mechanical hypersensitivity, due to which even gentle movements or touching the skin close to the tumour may induce strong pain [4,5]. These bone cancer-induced symptoms can severely reduce quality of life.1Experimental animal models in the study of mechanisms of bone cancer painDevelopment of experimental animal models for the study of bone cancer pain has significantly advanced our understanding of underlying mechanisms. Behaviorally, animal models of bone cancer pain induce in the affected limb guarding and mechanical hypersensitivity mirroring continuous pain and tactile allodynia in the clinic [4].

Journal

Scandinavian Journal of Painde Gruyter

Published: Dec 29, 2017

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