In this issue of the Scandinavian Journal of Pain Tania Schjødt Jørgensen and co-workers in Aalborg and Copenhagen report an interesting clinical neurophysiological study on 10 knee osteoarthritis (OA) patients . These OA patients were the bravest of 64 invited OA-patients to let the researchers provoke more pain in and around their OA-knee by having hypertonic or isotonic saline injected into their infrapatellar fat-pad. This was a randomized cross-over study with either the hypertonic saline causing extra pain or isotonic saline provoking none or only mild extra pain.They found that the experimental pain from injection of hypertonic saline caused a significant lowering of the pressure pain threshold (PPT) and a significant fascilitation of temporal summation of pressure pain stimulation near the knee joint. They did not observe such changes after isotonic saline injection or in a control site on the arm on the opposite side of the body. The authors concluded that in these 10 patients with OA of moderate severity, the pain modulating systems appear to be intact.1Why can surgeons remove chronic pain with an artificial joint in about 80% of knee OA patients?Osteoarthritis pain is not only pure nociceptive pain from the degenerative processes in and around
Scandinavian Journal of Pain – de Gruyter
Published: Jan 1, 2015
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