Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene

Isolation of high purity 73Se using solid phase extraction after selective... AbstractA fast and efficient process for the production of the PET radionuclide 73Se was developed using 75Se as a surrogate. 75Se was separated from proton irradiated arsenic trioxide by reaction with 2,3-diaminonaphthalene to 4,5-[75Se]benzopiazelenol. This compound was purified using SPE column chromatography and subsequently decomposed with hydrogen peroxide. For further chemical conversions [75Se]selenite was reduced to elemental [75Se]selenium by either using thiosulfate or sulfur dioxide. The recovery yield of 75Se from the target amounted to 43%. The utility of the isolated 75Se for radiosyntheses was demonstrated by the successful preparation of [75Se]selenomethionine. The methodology developed using 75Se was successfully transformed to 73Se. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Radiochimica Acta de Gruyter

Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene

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Publisher
De Gruyter
Copyright
©2018 Walter de Gruyter GmbH, Berlin/Boston
ISSN
2193-3405
eISSN
2193-3405
D.O.I.
10.1515/ract-2017-2864
Publisher site
See Article on Publisher Site

Abstract

AbstractA fast and efficient process for the production of the PET radionuclide 73Se was developed using 75Se as a surrogate. 75Se was separated from proton irradiated arsenic trioxide by reaction with 2,3-diaminonaphthalene to 4,5-[75Se]benzopiazelenol. This compound was purified using SPE column chromatography and subsequently decomposed with hydrogen peroxide. For further chemical conversions [75Se]selenite was reduced to elemental [75Se]selenium by either using thiosulfate or sulfur dioxide. The recovery yield of 75Se from the target amounted to 43%. The utility of the isolated 75Se for radiosyntheses was demonstrated by the successful preparation of [75Se]selenomethionine. The methodology developed using 75Se was successfully transformed to 73Se.

Journal

Radiochimica Actade Gruyter

Published: Jun 27, 2018

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