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Initial presentations and associated clinical findings in patients with classical congenital adrenal hyperplasia

Initial presentations and associated clinical findings in patients with classical congenital... AbstractBackground:The objective of this study was to investigate the initial presenting features of children with classical congenital adrenal hyperplasia (CAH).Methods:This is a descriptive retrospective study over a period of 5 years. Data analysis was performed using Statistical Package for Social Science.Results:Ambiguous genitalia (AG) was the commonest initial presentation marking 50.7% of the patients. On the other hand, 33.3% presented with a salt-losing crisis, 4.1% of whom presented with shock, while 14.5% had a combined presentation of both AG and a salt-losing crisis.Conclusions:CAH should be highly suspected in all females born with AG. Contrarily, affected male newborns more frequently present with a salt-losing crisis, and considering the recent institution of newborn screening in Saudi Arabia, earlier detection in these children is anticipated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

Initial presentations and associated clinical findings in patients with classical congenital adrenal hyperplasia

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Publisher
de Gruyter
Copyright
©2018 Walter de Gruyter GmbH, Berlin/Boston
ISSN
2191-0251
eISSN
2191-0251
DOI
10.1515/jpem-2018-0029
pmid
29750654
Publisher site
See Article on Publisher Site

Abstract

AbstractBackground:The objective of this study was to investigate the initial presenting features of children with classical congenital adrenal hyperplasia (CAH).Methods:This is a descriptive retrospective study over a period of 5 years. Data analysis was performed using Statistical Package for Social Science.Results:Ambiguous genitalia (AG) was the commonest initial presentation marking 50.7% of the patients. On the other hand, 33.3% presented with a salt-losing crisis, 4.1% of whom presented with shock, while 14.5% had a combined presentation of both AG and a salt-losing crisis.Conclusions:CAH should be highly suspected in all females born with AG. Contrarily, affected male newborns more frequently present with a salt-losing crisis, and considering the recent institution of newborn screening in Saudi Arabia, earlier detection in these children is anticipated.

Journal

Journal of Pediatric Endocrinology and Metabolism – de Gruyter

Published: Jun 27, 2018

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