Important new insight in pain and pain treatment induced changes in functional connectivity between the Pain Matrix and the Salience, Central Executive, and Sensorimotor networks

Important new insight in pain and pain treatment induced changes in functional connectivity... Kolesar et al. [1] are to be congratulated on this article, which goes one step beyond their original article [2] in analyzing brain activity at rest in patients with Failed Back Surgery Syndrome (FBSS). Together, data from both articles help us to understand more about brain function in chronic pain but also what might set FBSS apart from other forms of chronic pain. The original article looked at alterations in the Default Mode Network (DMN) using functional magnetic resonance imaging (fMRI). Reading these and other pertinent articles is rather difficult for those of us not familiar with brain neuroanatomy, neurophysiology, and the burgeoning literature on fMRI and Positron Emission Tomography (PET) in pain but it is worthwhile to persist since this field, especially that focusing on brain activity at rest in chronic pain patients, is crucial to understand many of the clinical signs and symptoms common to those with various chronic pain syndromes.1The Default Mode Network (DMN) – “the mind in neutral”The DMN is what the brain does at rest when there is no reason to focus on a specific task, mental or physical – “the mind in neutral” if you will. It is an activity pattern of connectivity http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

Important new insight in pain and pain treatment induced changes in functional connectivity between the Pain Matrix and the Salience, Central Executive, and Sensorimotor networks

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Publisher
De Gruyter
Copyright
© 2017 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2017.02.005
Publisher site
See Article on Publisher Site

Abstract

Kolesar et al. [1] are to be congratulated on this article, which goes one step beyond their original article [2] in analyzing brain activity at rest in patients with Failed Back Surgery Syndrome (FBSS). Together, data from both articles help us to understand more about brain function in chronic pain but also what might set FBSS apart from other forms of chronic pain. The original article looked at alterations in the Default Mode Network (DMN) using functional magnetic resonance imaging (fMRI). Reading these and other pertinent articles is rather difficult for those of us not familiar with brain neuroanatomy, neurophysiology, and the burgeoning literature on fMRI and Positron Emission Tomography (PET) in pain but it is worthwhile to persist since this field, especially that focusing on brain activity at rest in chronic pain patients, is crucial to understand many of the clinical signs and symptoms common to those with various chronic pain syndromes.1The Default Mode Network (DMN) – “the mind in neutral”The DMN is what the brain does at rest when there is no reason to focus on a specific task, mental or physical – “the mind in neutral” if you will. It is an activity pattern of connectivity

Journal

Scandinavian Journal of Painde Gruyter

Published: Dec 29, 2017

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