In this issue of Scandinavian Journal of Pain, Nasser and Birk Möller present a topical review on the role of the guanosine triphosphate cyclohydrolase 1 (GCH1) genetics and the down-stream effects of tetrahydrobiopterin (BH4) in the pathophysiology of pain . The review is based on the findings presented in Dr. Nasser’s recent PhD dissertation, titled “Involvement of the GCH1 gene and the cofactor tetrahydrobiopterin in pain – a comparative study in mice and man” (University of Copenhagen 2013).1Why does acute pain become chronic in some patients?In patients undergoing the same surgical procedure, it has been shown that about 80% are pain free when followed up after some years, but around 20% still suffer from varying degrees of persistent pain, in some cases severe pain. Is this long term outcome concerning chronic pain due to a genetic disposition? Many research groups are at present investigating this question, and a multitude of candidate genes predisposing for vulnerability to chronic pain are suggested .2In search for a genetic explanation for pain vulnerability – the role of GCH1 and BH4The BH4 story in the pain field was kindled by an important publication by Tegeder et al. , showing that a certain GCH1 gene
Scandinavian Journal of Pain – de Gruyter
Published: Dec 29, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera