Glucocorticoids – Efficient analgesics against postherpetic neuralgia?

Glucocorticoids – Efficient analgesics against postherpetic neuralgia? In this issue of the Scandinavian Journal of Pain, Mienke Rijsdijk, MD, presents the original experiments entitled “Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model” [1]. Intrathecal administration of methylprednisolone acetate (MPA) in a randomized controlled clinical trial on intractable postherpetic neuralgia (PHN) patients did not result in any analgesic effects [2], which is in contrast to findings by others [3, 4, 5, 6]. Consequently, studies on rats seek to explain these observations further.1The clinical problemPHN is one of many forms of neuropathic pain and is characterized by severe burning pain, hypersensitivity and/or numbness in affected areas. PHN is caused by the varicella zoster virus (VZV), to which >95% of the world’s population has been exposed [7,8]. Varicella, also known as chickenpox, is a generally harmless childhood illness that manifests itself through fever and small fluid-filled vesicles that can cover the entire body. VZV further infects multiple cranial nerve ganglia, dorsal root ganglia as well as autonomic and enteric ganglia [9,10,11]. After the varicella outbreak, the immune system maintains a host-virus equilibrium (latent infection) commonly providing lifelong VZV immunity [12,13]. Herpes zoster (HZ), also known as shingles, occurs when the virus is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

Glucocorticoids – Efficient analgesics against postherpetic neuralgia?

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Publisher
De Gruyter
Copyright
© 2017 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2017.03.003
Publisher site
See Article on Publisher Site

Abstract

In this issue of the Scandinavian Journal of Pain, Mienke Rijsdijk, MD, presents the original experiments entitled “Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model” [1]. Intrathecal administration of methylprednisolone acetate (MPA) in a randomized controlled clinical trial on intractable postherpetic neuralgia (PHN) patients did not result in any analgesic effects [2], which is in contrast to findings by others [3, 4, 5, 6]. Consequently, studies on rats seek to explain these observations further.1The clinical problemPHN is one of many forms of neuropathic pain and is characterized by severe burning pain, hypersensitivity and/or numbness in affected areas. PHN is caused by the varicella zoster virus (VZV), to which >95% of the world’s population has been exposed [7,8]. Varicella, also known as chickenpox, is a generally harmless childhood illness that manifests itself through fever and small fluid-filled vesicles that can cover the entire body. VZV further infects multiple cranial nerve ganglia, dorsal root ganglia as well as autonomic and enteric ganglia [9,10,11]. After the varicella outbreak, the immune system maintains a host-virus equilibrium (latent infection) commonly providing lifelong VZV immunity [12,13]. Herpes zoster (HZ), also known as shingles, occurs when the virus is

Journal

Scandinavian Journal of Painde Gruyter

Published: Jul 1, 2017

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