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/lp/degruyter/eco-friendly-synthesis-characterization-and-drug-likeness-properties-rge3eUiC1q
- Publisher
- de Gruyter
- Copyright
- ©2018 Walter de Gruyter GmbH, Berlin/Boston
- ISSN
- 2191-9550
- eISSN
- 2191-9550
- DOI
- 10.1515/gps-2016-0199
- Publisher site
- See Article on Publisher Site
Abstract
AbstractSeveral pyridopyrimidine derivatives have been synthesized through different synthetic processes. The different physicochemical factors for their synthesis were also discussed. A comparison between the conventional and microwave-assisted synthesis was conducted by comparing total time of reaction and its yield percentage. Most of the produced uracils were established for their anti-inflammatory, analgesic, and antioxidant activities. Compounds 1 and 3 were demonstrated as the best results against DNA damage, whereas compounds 2a and 2b exhibited an effective anti-inflammatory activity. Moreover, the Lipinski rule parameters were calculated for the synthesized compounds. The results indicated that compounds 1, 2a and 5 have good potential for subsequent development bioactivity.
Journal
Green Processing and Synthesis – de Gruyter
Published: Jun 27, 2018