Dysregulated pathways for off-pump coronary artery bypass grafting

Dysregulated pathways for off-pump coronary artery bypass grafting AbstractBackgroundThe objective of this paper was to identify dysregulated myocardial pathways with off-pump coronary artery bypass grafting (OPCABG) based on pathway interaction network (PIN).MethodologyTo achieve this goal, firstly, gene expression profiles, protein-protein interactions (PPIs) and pathway data were collected. Secondly, we constructed a PIN by integrating these data and Pearson correlation coefficient (PCC) algorithm. Next, for every pathway in the PIN, its activity was counted dependent on the principal component analysis (PCA) method to select the seed pathway. Ultimately, a minimum pathway set (MPS) was extracted from the PIN on the basis of the seed pathway and the area under the receiver operating characteristics curve (AUROC) index, and pathways in the MPS were denoted as dysregulated pathways.ResultsThe PIN had 1,189 nodes and 22,756 interactions, of which mitochondrial translation termination was the seed pathway. Starting with mitochondrial translation termination, a MPS (AUROC = 0.983) with 7 nodes and 26 edges was obtained. The 7 pathways were regarded as dysregulated myocardial pathways with OPCABG.ConclusionThe findings might provide potential biomarkers to diagnose early, serve as the evidence to perform the OPCABG and predict inflammatory response and myocardial reperfusion injury after OPCABG in the future. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Open Life Sciences de Gruyter

Dysregulated pathways for off-pump coronary artery bypass grafting

Loading next page...
 
/lp/degruyter/dysregulated-pathways-for-off-pump-coronary-artery-bypass-grafting-OA0TQLTAsU
Publisher
De Gruyter Open
Copyright
© 2017 Xu Li et al.
ISSN
2391-5412
eISSN
2391-5412
D.O.I.
10.1515/biol-2017-0047
Publisher site
See Article on Publisher Site

Abstract

AbstractBackgroundThe objective of this paper was to identify dysregulated myocardial pathways with off-pump coronary artery bypass grafting (OPCABG) based on pathway interaction network (PIN).MethodologyTo achieve this goal, firstly, gene expression profiles, protein-protein interactions (PPIs) and pathway data were collected. Secondly, we constructed a PIN by integrating these data and Pearson correlation coefficient (PCC) algorithm. Next, for every pathway in the PIN, its activity was counted dependent on the principal component analysis (PCA) method to select the seed pathway. Ultimately, a minimum pathway set (MPS) was extracted from the PIN on the basis of the seed pathway and the area under the receiver operating characteristics curve (AUROC) index, and pathways in the MPS were denoted as dysregulated pathways.ResultsThe PIN had 1,189 nodes and 22,756 interactions, of which mitochondrial translation termination was the seed pathway. Starting with mitochondrial translation termination, a MPS (AUROC = 0.983) with 7 nodes and 26 edges was obtained. The 7 pathways were regarded as dysregulated myocardial pathways with OPCABG.ConclusionThe findings might provide potential biomarkers to diagnose early, serve as the evidence to perform the OPCABG and predict inflammatory response and myocardial reperfusion injury after OPCABG in the future.

Journal

Open Life Sciencesde Gruyter

Published: Nov 23, 2017

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial