Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for children and adolescents

Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for... AbstractBackground:Bone metabolism involves many complex pathways that are disturbed by several bone diseases. The literature shows some limitations concerning pediatric reference intervals to bone markers, mainly because of the low number of patients included in the studies, the heterogeneity of methods, beyond the fact that it is time-consuming and expensive. The aim of this study was to determine reference values for β-isomerized carboxy-terminal telopeptides collagen type I (β-CTX), a marker of bone resorption, for children and adolescents.Methods:Blood samples from 246 patients were collected and β-CTX was measured using an electrochemiluminescence immunoassay (ECLI).Results and conclusions:We propose reference ranges for β-CTX concentration from the 2.5 percentile and 97.5 percentile for each age group. The reference values obtained, concerning children and adolescents, might be useful in the evaluation of diseases such as osteosarcoma and anorexia in both childhood as adolescence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for children and adolescents

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Publisher
de Gruyter
Copyright
©2018 Walter de Gruyter GmbH, Berlin/Boston
ISSN
2191-0251
eISSN
2191-0251
D.O.I.
10.1515/jpem-2018-0005
Publisher site
See Article on Publisher Site

Abstract

AbstractBackground:Bone metabolism involves many complex pathways that are disturbed by several bone diseases. The literature shows some limitations concerning pediatric reference intervals to bone markers, mainly because of the low number of patients included in the studies, the heterogeneity of methods, beyond the fact that it is time-consuming and expensive. The aim of this study was to determine reference values for β-isomerized carboxy-terminal telopeptides collagen type I (β-CTX), a marker of bone resorption, for children and adolescents.Methods:Blood samples from 246 patients were collected and β-CTX was measured using an electrochemiluminescence immunoassay (ECLI).Results and conclusions:We propose reference ranges for β-CTX concentration from the 2.5 percentile and 97.5 percentile for each age group. The reference values obtained, concerning children and adolescents, might be useful in the evaluation of diseases such as osteosarcoma and anorexia in both childhood as adolescence.

Journal

Journal of Pediatric Endocrinology and Metabolismde Gruyter

Published: Jun 27, 2018

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