Butin attenuates brain edema in a rat model of intracerebral hemorrhage by anti inflammatory pathway

Butin attenuates brain edema in a rat model of intracerebral hemorrhage by anti inflammatory pathway AbstractBackgroundThis study evaluates the effect of butin against brain edema in intracerebral hemorrhage (ICH).MethodologyICH was induced by injecting bacterial collagenase in the brain and all the animals were separated into four groups such as control group, ICH group treated with vehicle, Butin 25 and 50 mg/kg group receives butin (25 and 50 mg/kg, i.p.)60 min after the induction of ICH in all animals. One day after neurological score, hemorrhagic injury and expressions of protein responsible for apoptosis and inflammatory cytokines were assessed in the brain tissue of ICH rats.ResultNeurological scoring significantly increased and hemorrhagic lesion volume decreased in butin treated group of rats compared to ICH group. However, treatment with butin significantly decreases the ratio of Bax/Bcl-2 and protein expression of Cleaved caspase-3 than ICH group in dose dependent manner. Level of inflammatory mediators such as tumor necrosis factor-α (TNF-α) and interlukin-6 (IL-6) in the brain tissues were significantly decreased in the butin treated group than ICH group. In addition butin attenuates the altered signaling pathway of NF-κB in the brain tissues of ICH rats.ConclusionOur study concludes that butin attenuates the altered behavior and neuronal condition in ICH rats by reducing apoptosis and inflammatory response. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Translational Neuroscience de Gruyter

Butin attenuates brain edema in a rat model of intracerebral hemorrhage by anti inflammatory pathway

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Publisher
De Gruyter Open
Copyright
© 2018 Peiyu Li and Cheng Jiwu
ISSN
2081-6936
eISSN
2081-6936
D.O.I.
10.1515/tnsci-2018-0002
Publisher site
See Article on Publisher Site

Abstract

AbstractBackgroundThis study evaluates the effect of butin against brain edema in intracerebral hemorrhage (ICH).MethodologyICH was induced by injecting bacterial collagenase in the brain and all the animals were separated into four groups such as control group, ICH group treated with vehicle, Butin 25 and 50 mg/kg group receives butin (25 and 50 mg/kg, i.p.)60 min after the induction of ICH in all animals. One day after neurological score, hemorrhagic injury and expressions of protein responsible for apoptosis and inflammatory cytokines were assessed in the brain tissue of ICH rats.ResultNeurological scoring significantly increased and hemorrhagic lesion volume decreased in butin treated group of rats compared to ICH group. However, treatment with butin significantly decreases the ratio of Bax/Bcl-2 and protein expression of Cleaved caspase-3 than ICH group in dose dependent manner. Level of inflammatory mediators such as tumor necrosis factor-α (TNF-α) and interlukin-6 (IL-6) in the brain tissues were significantly decreased in the butin treated group than ICH group. In addition butin attenuates the altered signaling pathway of NF-κB in the brain tissues of ICH rats.ConclusionOur study concludes that butin attenuates the altered behavior and neuronal condition in ICH rats by reducing apoptosis and inflammatory response.

Journal

Translational Neurosciencede Gruyter

Published: May 8, 2018

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