Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Body composition and metabolic health of young male adults with childhood-onset multiple pituitary hormone deficiency after cessation of growth hormone treatment

Body composition and metabolic health of young male adults with childhood-onset multiple... AbstractBackground:Recombinant human growth hormone (rhGH) replacement therapy is usually stopped after linear growth completion in patients with growth hormone deficiency. In patients with multiple pituitary hormone deficiency (MPHD), the long-term effects of discontinuation of rhGH replacement are unknown.Methods:In this study, the anthropometric and metabolic parameters of 24 male patients with adult growth hormone deficiency (AGHD) due to MPHD in childhood after cessation of rhGH therapy for a mean of 7.1 years were measured and compared with 35 age-matched controls. Body composition was evaluated by bioelectrical impedance analysis (BIA).Results:In the AGHD group, body mass index (BMI) was significantly increased and 29.2% had obesity. The AGHD group had a 17.7 cm increase in waist circumference (WC). The fat free mass (FFM) was significantly lower in the AGHD group. Both the fat mass (FM) and percentage of fat mass (FM%) were significantly increased in the AGHD group. Both the systolic blood pressure (BP) and diastolic pressure were significantly lower in AGHD group. The lipid profile was generally similar in both groups, except for a decrease of high density lipoprotein-cholesterol (HDL-C) in the AGHD group. There was significant hyperuricemia in the AGHD group.Conclusions:Cessation of rhGH leads to a significant increase of FM in early adulthood in male patients with childhood-onset MPHD (CO-MPHD). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

Body composition and metabolic health of young male adults with childhood-onset multiple pituitary hormone deficiency after cessation of growth hormone treatment

Download PDF
5 pages

Loading next page...
 
/lp/degruyter/body-composition-and-metabolic-health-of-young-male-adults-with-sHhanFolfk
Publisher
de Gruyter
Copyright
©2018 Walter de Gruyter GmbH, Berlin/Boston
ISSN
2191-0251
eISSN
2191-0251
DOI
10.1515/jpem-2018-0019
pmid
29688888
Publisher site
See Article on Publisher Site

Abstract

AbstractBackground:Recombinant human growth hormone (rhGH) replacement therapy is usually stopped after linear growth completion in patients with growth hormone deficiency. In patients with multiple pituitary hormone deficiency (MPHD), the long-term effects of discontinuation of rhGH replacement are unknown.Methods:In this study, the anthropometric and metabolic parameters of 24 male patients with adult growth hormone deficiency (AGHD) due to MPHD in childhood after cessation of rhGH therapy for a mean of 7.1 years were measured and compared with 35 age-matched controls. Body composition was evaluated by bioelectrical impedance analysis (BIA).Results:In the AGHD group, body mass index (BMI) was significantly increased and 29.2% had obesity. The AGHD group had a 17.7 cm increase in waist circumference (WC). The fat free mass (FFM) was significantly lower in the AGHD group. Both the fat mass (FM) and percentage of fat mass (FM%) were significantly increased in the AGHD group. Both the systolic blood pressure (BP) and diastolic pressure were significantly lower in AGHD group. The lipid profile was generally similar in both groups, except for a decrease of high density lipoprotein-cholesterol (HDL-C) in the AGHD group. There was significant hyperuricemia in the AGHD group.Conclusions:Cessation of rhGH leads to a significant increase of FM in early adulthood in male patients with childhood-onset MPHD (CO-MPHD).

Journal

Journal of Pediatric Endocrinology and Metabolism – de Gruyter

Published: May 24, 2018

References

  • Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects Swedish Study Group for Growth Hormone Treatment in Children
  • Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults
  • Evaluation of permanent growth hormone deficiency (GHD) in young adults with childhood onset GHD: a multicenter study
  • Continued growth hormone (GH) treatment after final height is necessary to complete somatic development in childhood-onset GH-deficient patients
  • Endocrine control of body composition in infancy, childhood, and puberty
  • Continuation of growth hormone (GH) replacement in GH-deficient patients during transition from childhood to adulthood: a two-year placebo-controlled study
  • Clinical characteristics of Japanese adults with growth hormone deficiency: a HypoCCS database study
  • Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-deficient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients
  • Individual risk factors of the metabolic syndrome in adult patients with growth hormone deficiency – a cross-sectional case-control study
  • Continued growth hormone (GH) treatment after final height is necessary to complete somatic development in childhood-onset GH-deficient patients
  • Evaluation and treatment of adult growth hormone deficiency: an endocrine society clinical practice guideline
  • Lipid accumulation product: a simple and accurate index for predicting metabolic syndrome in patients with adult growth hormone deficiency
  • Evaluation of permanent growth hormone deficiency (GHD) in young adults with childhood onset GHD: a multicenter study
  • Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population
  • Management of adult growth hormone deficiency at Peking Union Medical College Hospital: a survey among physicians
  • Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults
  • Fat distribution and health in obesity
  • Lipid accumulation product: a simple and accurate index for predicting metabolic syndrome in patients with adult growth hormone deficiency
  • Childhood-onset adult growth hormone deficiency: clinical, hormonal, and radiological assessment in a single center in China
  • Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-deficient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients
  • Endocrine control of body composition in infancy, childhood, and puberty
  • Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects Swedish Study Group for Growth Hormone Treatment in Children
  • Individual risk factors of the metabolic syndrome in adult patients with growth hormone deficiency – a cross-sectional case-control study
  • A new international diabetes federation worldwide definition of the metabolic syndrome: the rationale and the results
  • A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices
  • Characterization of adult onset growth hormone deficiency syndrome in patients with hypothalamopituitary diseases: Asian Indian data
  • Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population
  • Fat distribution and health in obesity
  • The effect of 24 months recombinant human growth hormone (rh-GH) on LDL cholesterol, triglyceride-rich lipoproteins and apo [a] in hypopituitary adults previously treated with conventional replacement therapy
  • Continuation of growth hormone (GH) replacement in GH-deficient patients during transition from childhood to adulthood: a two-year placebo-controlled study
  • Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: a two year study
  • Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: a two year study
  • A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices
  • The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH
  • Clinical characteristics of Japanese adults with growth hormone deficiency: a HypoCCS database study
  • A new international diabetes federation worldwide definition of the metabolic syndrome: the rationale and the results
  • Assessment of human body composition using dual-energy x-ray absorptiometry and bioelectrical impedance analysis
  • Evaluation and treatment of adult growth hormone deficiency: an endocrine society clinical practice guideline
  • Management of adult growth hormone deficiency at Peking Union Medical College Hospital: a survey among physicians
  • The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH
  • The effect of 24 months recombinant human growth hormone (rh-GH) on LDL cholesterol, triglyceride-rich lipoproteins and apo [a] in hypopituitary adults previously treated with conventional replacement therapy
  • Characterization of adult onset growth hormone deficiency syndrome in patients with hypothalamopituitary diseases: Asian Indian data
  • Childhood-onset adult growth hormone deficiency: clinical, hormonal, and radiological assessment in a single center in China
  • Assessment of human body composition using dual-energy x-ray absorptiometry and bioelectrical impedance analysis