Access the full text.
Sign up today, get DeepDyve free for 14 days.
Jonathan Godwin, X. Ge, K. Stephan, A. Jurisch, S. Tullius, J. Iacomini (2010)
Identification of a microRNA signature of renal ischemia reperfusion injuryProceedings of the National Academy of Sciences, 107
Quan-Hui Yang, Dawei Liu, Y. Long, Hong-zhong Liu, W. Chai, Xiaoting Wang (2009)
Acute renal failure during sepsis: potential role of cell cycle regulation.The Journal of infection, 58 6
W. Han, S. Waikar, A. Johnson, R. Betensky, C. Dent, P. Devarajan, J. Bonventre (2008)
Urinary biomarkers in the early diagnosis of acute kidney injury.Kidney international, 73 7
M. Haase, P. Devarajan, A. Haase-Fielitz, R. Bellomo, Dr. Cruz, G. Wagener, C. Krawczeski, J. Koyner, P. Murray, M. Zappitelli, S. Goldstein, K. Makris, C. Ronco, J. Mårtensson, C. Martling, P. Venge, E. Siew, L. Ware, T. Ikizler, P. Mertens (2011)
The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies.Journal of the American College of Cardiology, 57 17
K. Schmidt-Ott (2011)
Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury--where do we stand today?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26 3
J. Belcher, G. Garcia‐Tsao, A. Sanyal, H. Thiessen-Philbrook, A. Peixoto, M. Perazella, N. Ansari, Joseph Lim, S. Coca, C. Parikh (2014)
Urinary biomarkers and progression of AKI in patients with cirrhosis.Clinical journal of the American Society of Nephrology : CJASN, 9 11
T. Ichimura, E. Asseldonk, B. Humphreys, L. Gunaratnam, J. Duffield, J. Bonventre (2008)
Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.The Journal of clinical investigation, 118 5
R. Bellomo, J. Kellum, C. Ronco (2012)
Acute kidney injuryThe Lancet, 380
M. Lochner, I. Förster (2003)
Anti-Interleukin-18 Therapy in Murine Models of Inflammatory Bowel DiseasePathobiology, 70
K. Fujiu, I. Manabe, R. Nagai (2011)
Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice.The Journal of clinical investigation, 121 9
J. Mishra, C. Dent, Ridwan Tarabishi, M. Mitsnefes, Q. Ma, C. Kelly, Stacey Ruff, K. Zahedi, M. Shao, J. Bean, K. Mori, J. Barasch, P. Devarajan (2005)
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgeryThe Lancet, 365
RESEARCH Open Access Management of bleeding and coagulopathy following major trauma: an updated European
C. Parikh, P. Devarajan, M. Zappitelli, K. Sint, H. Thiessen-Philbrook, Simon Li, Richard Kim, J. Koyner, S. Coca, C. Edelstein, M. Shlipak, A. Garg, C. Krawczeski (2011)
Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery.Journal of the American Society of Nephrology : JASN, 22 9
International Consensus Conference of the Acute Dialysis Quality Initiative (adqi) Group
T. Vogl, K. Tenbrock, S. Ludwig, Nadja Leukert, C. Ehrhardt, M. Zoelen, W. Nacken, D. Foell, T. Poll, C. Sorg, J. Roth (2007)
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shockNature Medicine, 13
E. Homsi, Patrícia Janino, J. Faria (2006)
Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure.Kidney international, 69 8
J. Megyesi, R. Safirstein, P. Price (1998)
Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure.The Journal of clinical investigation, 101 4
A. Chmurzyńska (2010)
The multigene family of fatty acid-binding proteins (FABPs): Function, structure and polymorphismJournal of Applied Genetics, 47
J. Bonventre (2009)
Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24 11
E. Siew, A. Davenport (2014)
The growth of acute kidney injury: a rising tide or just closer attention to detail?Kidney International, 87
S. Molinas, César Cortés-González, Yvett González-Bobadilla, L. Monasterolo, C. Cruz, M. Elías, N. Bobadilla, L. Trumper (2009)
Effects of Losartan Pretreatment in an Experimental Model of Ischemic Acute Kidney InjuryNephron Experimental Nephrology, 112
D. Sweetser, R. Heuckeroth, J. Gordon (1987)
The metabolic significance of mammalian fatty-acid-binding proteins: abundant proteins in search of a function.Annual review of nutrition, 7
J. Ramirez-Sandoval, W. Herrington, L. Morales-Buenrostro (2015)
Neutrophil gelatinase-associated lipocalin in kidney transplantation: A review.Transplantation reviews, 29 3
M. Meersch, C. Schmidt, H. Aken, S. Martens, J. Rossaint, K. Singbartl, D. Görlich, J. Kellum, A. Zarbock (2014)
Urinary TIMP-2 and IGFBP7 as Early Biomarkers of Acute Kidney Injury and Renal Recovery following Cardiac SurgeryPLoS ONE, 9
T. Ichimura, C. Brooks, J. Bonventre (2012)
Kim-1/Tim-1 and Immune cells: Shifting SandsKidney international, 81
C. Dinarello (2007)
Interleukin-18 and the pathogenesis of inflammatory diseases.Seminars in nephrology, 27 1
A. Bihorac, L. Chawla, A. Shaw, A. Al-Khafaji, D. Davison, G. DeMuth, R. Fitzgerald, M. Gong, D. Graham, K. Gunnerson, Michael Heung, S. Jortani, E. Kleerup, J. Koyner, K. Krell, Jennifer Letourneau, M. Lissauer, J. Miner, H. Nguyen, L. Ortega, W. Self, R. Sellman, Jing Shi, J. Straseski, J. Szalados, S. Wilber, M. Walker, Jason Wilson, R. Wunderink, J. Zimmerman, J. Kellum (2014)
Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication.American journal of respiratory and critical care medicine, 189 8
F. Gonzalez, F. Vincent (2012)
Biomarkers for acute kidney injury in critically ill patients.Minerva anestesiologica, 78 12
Tokunori Yamamoto, E. Noiri, Y. Ono, Kent Doi, K. Negishi, A. Kamijo, K. Kimura, T. Fujita, T. Kinukawa, H. Taniguchi, Kazuo Nakamura, M. Goto, N. Shinozaki, S. Ohshima, T. Sugaya (2007)
Renal L-type fatty acid--binding protein in acute ischemic injury.Journal of the American Society of Nephrology : JASN, 18 11
E. Kankuri, E. Mervaala, M. Storvik, Aija Ahola, J. Levijoki, D. Müller, P. Finckenberg, E. Mervaala (2015)
Exacerbation of acute kidney injury by bone marrow stromal cells from rats with persistent renin-angiotensin system activation.Clinical science, 128 11
Isaac Hall, S. Coca, M. Perazella, Umo Eko, R. Luciano, P. Peter, W. Han, C. Parikh (2011)
Risk of poor outcomes with novel and traditional biomarkers at clinical AKI diagnosis.Clinical journal of the American Society of Nephrology : CJASN, 6 12
P. Devarajan (2010)
Review: Neutrophil gelatinase‐associated lipocalin: A troponin‐like biomarker for human acute kidney injuryNephrology, 15
F. Heller, S. Frischmann, M. Grünbaum, W. Zidek, T. Westhoff (2011)
Urinary calprotectin and the distinction between prerenal and intrinsic acute kidney injury.Clinical journal of the American Society of Nephrology : CJASN, 6 10
Andrés Barrilli, S. Molinas, G. Petrini, M. Menacho, M. Elías (2004)
Losartan reverses fibrotic changes in cortical renal tissue induced by ischemia or ischemia-reperfusion without changes in renal functionMolecular and Cellular Biochemistry, 260
(2007)
Urinary N-Acetyl-β-(D)-Glucosaminidase Activity and Kidney Injury Molecule-1 Level Are Associated with Adverse Outcomes in Acute Renal Failure
D. Wheeler, P. Devarajan, Q. Ma, K. Harmon, Marie Monaco, N. Cvijanovich, H. Wong (2008)
Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shockCritical Care Medicine, 36
S. Seeliger, T. Vogl, I. Engels, J. Schröder, C. Sorg, C. Sunderkötter, C. Sunderkötter, J. Roth (2003)
Expression of calcium-binding proteins MRP8 and MRP14 in inflammatory muscle diseases.The American journal of pathology, 163 3
M. Bell, A. Larsson, P. Venge, R. Bellomo, J. Mårtensson (2015)
Assessment of Cell-Cycle Arrest Biomarkers to Predict Early and Delayed Acute Kidney InjuryDisease Markers, 2015
C. Parikh, D. Moledina, S. Coca, H. Thiessen-Philbrook, A. Garg (2016)
Application of new acute kidney injury biomarkers in human randomized controlled trials.Kidney international, 89 6
J. Koyner, A. Shaw, L. Chawla, E. Hoste, A. Bihorac, K. Kashani, M. Haase, Jing Shi, J. Kellum (2015)
Tissue Inhibitor Metalloproteinase-2 (TIMP-2)⋅IGF-Binding Protein-7 (IGFBP7) Levels Are Associated with Adverse Long-Term Outcomes in Patients with AKI.Journal of the American Society of Nephrology : JASN, 26 7
F. Pike, R. Murugan, Christopher Keener, P. Palevsky, A. Vijayan, M. Unruh, Kevin Finkel, X. Wen, J. Kellum (2015)
Biomarker Enhanced Risk Prediction for Adverse Outcomes in Critically Ill Patients Receiving RRT.Clinical journal of the American Society of Nephrology : CJASN, 10 8
P. Murray, P. Devarajan, A. Levey, K. Eckardt, J. Bonventre, R. Lombardi, S. Herget-Rosenthal, A. Levin (2008)
A framework and key research questions in AKI diagnosis and staging in different environments.Clinical journal of the American Society of Nephrology : CJASN, 3 3
M. Zappitelli, K. Washburn, A. Arıkan, L. Loftis, Q. Ma, P. Devarajan, C. Parikh, S. Goldstein (2007)
Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort studyCritical Care, 11
J. Prowle, P. Calzavacca, E. Licari, E. Ligabo, J. Echeverri, S. Bagshaw, A. Haase-Fielitz, M. Haase, V. Ostland, E. Noiri, M. Westerman, P. Devarajan, R. Bellomo (2015)
Combination of biomarkers for diagnosis of acute kidney injury after cardiopulmonary bypassRenal Failure, 37
G. Wagener, M. Minhaz, Fallon Mattis, Mihwa Kim, J. Emond, H. Lee (2011)
Urinary neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after orthotopic liver transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26 5
A. Sakhuja, G. Kumar, Shipra Gupta, T. Mittal, A. Taneja, R. Nanchal (2015)
Acute Kidney Injury Requiring Dialysis in Severe Sepsis.American journal of respiratory and critical care medicine, 192 8
Michael Garfinkle, J. Barton (2016)
Pedal edema and jugular venous pressure for volume overload in peritoneal dialysis patientsCanadian Journal of Kidney Health and Disease, 3
A. Wetz, E. Richardt, Saskia Wand, Nils Kunze, H. Schotola, M. Quintel, A. Bräuer, O. Moerer (2015)
Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?Critical Care, 19
B. Molitoris (2013)
Measuring glomerular filtration rate in the intensive care unit: no substitutes pleaseCritical Care, 17
V. Hvidberg, C. Jacobsen, R. Strong, J. Cowland, S. Moestrup, N. Borregaard (2005)
The endocytic receptor megalin binds the iron transporting neutrophil‐gelatinase‐associated lipocalin with high affinity and mediates its cellular uptakeFEBS Letters, 579
J Am Soc Nephrol, 22
C. Parikh, E. Abraham, M. Ancukiewicz, C. Edelstein (2005)
Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit.Journal of the American Society of Nephrology : JASN, 16 10
R. Mehta, A. Bihorac, N. Selby, H. Quan, S. Goldstein, J. Kellum, C. Ronco, S. Bagshaw (2016)
Establishing a continuum of acute kidney injury – tracing AKI using data source linkage and long-term follow-up: Workgroup Statements from the 15th ADQI Consensus ConferenceCanadian Journal of Kidney Health and Disease, 3
H. Kobori, L. Harrison-Bernard, L. Navar (2002)
Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production.Kidney international, 61 2
Naledi Moyake, E. Buchmann, N. Crowther (2016)
Neutrophil gelatinase‐associated lipocalin as a diagnostic marker of acute kidney injury in pre‐eclampsiaJournal of Obstetrics and Gynaecology Research, 42
J Am Med Assoc, 307
M. Cullen, P. Murray, M. Fitzgibbon (2012)
Establishment of a reference interval for urinary neutrophil gelatinase-associated lipocalinAnnals of Clinical Biochemistry, 49
J. Wysocki, D. Batlle (2016)
Urinary Angiotensinogen: A Promising Biomarker of AKI Progression in Acute Decompensated Heart Failure: What Does It Mean?Clinical journal of the American Society of Nephrology : CJASN, 11 9
Yuanyuan Xie, Qin Wang, Chunlin Wang, Chao-jun Qi, Z. Ni, S. Mou (2016)
High urinary excretion of kidney injury molecule-1 predicts adverse outcomes in acute kidney injury: a case control studyCritical Care, 20
Yao Xu, Yuanyuan Xie, Xinghua Shao, Z. Ni, S. Mou (2015)
L-FABP: A novel biomarker of kidney disease.Clinica chimica acta; international journal of clinical chemistry, 445
T. Matsusaka, F. Niimura, A. Shimizu, I. Pastan, A. Saito, H. Kobori, A. Nishiyama, I. Ichikawa (2012)
Liver angiotensinogen is the primary source of renal angiotensin II.Journal of the American Society of Nephrology : JASN, 23 7
R. Mehta, J. Kellum, Sudhir Shah, B. Molitoris, C. Ronco, D. Warnock, A. Levin (2007)
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injuryCritical Care, 11
J. Ingelfinger, W. Zuo, Edward Fon, K. Ellison, V. Dzau (1990)
In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system.The Journal of clinical investigation, 85 2
S. Waikar, R. Betensky, J. Bonventre (2009)
Creatinine as the gold standard for kidney injury biomarker studies?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24 11
K. Pilarczyk, Michaela Edayadiyil-Dudásova, D. Wendt, E. Demircioğlu, J. Benedik, D. Dohle, H. Jakob, F. Dusse (2015)
Urinary [TIMP-2]*[IGFBP7] for early prediction of acute kidney injury after coronary artery bypass surgeryAnnals of Intensive Care, 5
Kent Doi, K. Negishi, T. Ishizu, D. Katagiri, T. Fujita, Takehiro Matsubara, N. Yahagi, T. Sugaya, E. Noiri (2011)
Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit*Critical Care Medicine, 39
D. Goetz, M. Holmes, N. Borregaard, Martin Bluhm, K. Raymond, R. Strong (2002)
The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.Molecular cell, 10 5
S. Parr, Amanda Clark, A. Bian, A. Shintani, N. Wickersham, L. Ware, T. Ikizler, E. Siew (2014)
Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injuryKidney international, 87
L. Chawla, R. Amdur, A. Shaw, Charles Faselis, C. Palant, P. Kimmel (2014)
Association between AKI and long-term renal and cardiovascular outcomes in United States veterans.Clinical journal of the American Society of Nephrology : CJASN, 9 3
A. Haase-Fielitz, R. Bellomo, P. Devarajan, M. Bennett, D. Story, G. Matalanis, U. Frei, D. Dragun, M. Haase (2009)
The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24 11
D. Cruz, S. Bagshaw, A. Maisel, A. Lewington, R. Thadhani, R. Chakravarthi, P. Murray, R. Mehta, L. Chawla (2013)
Use of biomarkers to assess prognosis and guide management of patients with acute kidney injury.Contributions to nephrology, 182
J. Pickering, Z. Endre (2016)
Bench to bedside: the next steps for biomarkers in acute kidney injury.American journal of physiology. Renal physiology, 311 4
J. Lorenzen, J. Kielstein, C. Hafer, Shashi Gupta, P. Kümpers, R. Faulhaber-Walter, H. Haller, D. Fliser, T. Thum (2011)
Circulating miR-210 predicts survival in critically ill patients with acute kidney injury.Clinical journal of the American Society of Nephrology : CJASN, 6 7
Stacie Coburn, S. Mitchell (2002)
Acute Renal Failure: Early detection and prompt intervention can improve outcomes.American Journal of Nursing, 102
C. Ronco (2016)
Acute kidney injury: from clinical to molecular diagnosisCritical Care, 20
Xin Lin, J. Yuan, Yingting Zhao, Y. Zha (2014)
Urine interleukin-18 in prediction of acute kidney injury: a systemic review and meta-analysisJournal of Nephrology, 28
D. Novick, Soohyun Kim, G. Kaplanski, C. Dinarello (2013)
Interleukin-18, more than a Th1 cytokine.Seminars in immunology, 25 6
Xian-fei Zeng, Jun-min Li, Yun Tan, Zhu Wang, Yong He, Jiang Chang, Hong Zhang, Hua Zhao, Xiaojie Bai, Fei Xie, Juan Sun, Yan Zhang (2014)
Performance of urinary NGAL and L-FABP in predicting acute kidney injury and subsequent renal recovery: a cohort study based on major surgeriesClinical Chemistry and Laboratory Medicine, 52
M. Ferguson, V. Vaidya, S. Waikar, F. Collings, K. Sunderland, Costas Gioules, J. Bonventre (2010)
Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury.Kidney international, 77 8
S. I, Iz, I. Trebichavský (2004)
Calprotectin - a pleiotropic molecule in acute and chronic inflammation.Physiological research, 53 3
Eugenia Singer, Antje Elger, S. Elitok, R. Kettritz, T. Nickolas, J. Barasch, F. Luft, K. Schmidt-Ott (2011)
Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes.Kidney international, 80 4
V. Vaidya, J. Ozer, Dieterle Frank, F. Collings, V. Ramírez, Sean Troth, N. Muniappa, D. Thudium, D. Gerhold, D. Holder, N. Bobadilla, E. Marrer, E. Perentes, A. Cordier, J. Vonderscher, G. Maurer, P. Goering, F. Sistare, J. Bonventre (2010)
Kidney Injury Molecule-1 Outperforms Traditional Biomarkers of Kidney Injury in Multi-site Preclinical Biomarker Qualification StudiesNature biotechnology, 28
E. Hoste, K. Kashani, N. Gibney, F. Wilson, C. Ronco, S. Goldstein, J. Kellum, S. Bagshaw, on Group (2016)
Impact of electronic-alerting of acute kidney injury: workgroup statements from the 15th ADQI Consensus ConferenceCanadian Journal of Kidney Health and Disease, 3
E. Noiri, Kent Doi, K. Negishi, Tamami Tanaka, Y. Hamasaki, T. Fujita, D. Portilla, T. Sugaya (2009)
Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury.American journal of physiology. Renal physiology, 296 4
Heidi Cheung, N. Chen, Z. Cao, N. Ono, P. Ohashi, W. Yeh (2005)
Accessory Protein-Like Is Essential for IL-18-Mediated Signaling1The Journal of Immunology, 174
E. Hoste, P. McCullough, K. Kashani, L. Chawla, M. Joannidis, A. Shaw, T. Feldkamp, D. Uettwiller-Geiger, P. McCarthy, Jing Shi, M. Walker, J. Kellum (2014)
Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkersNephrology Dialysis Transplantation, 29
R. mussi, S. Spadaro, L. Mirabella, C. Volta, G. Serio, F. Staffieri, M. Dambrosio, G. Cinnella, F. Bruno, S. Grasso (2015)
Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSVCritical Care, 20
J. Alge, N. Karakala, Benjamin Neely, M. Janech, J. Tumlin, L. Chawla, A. Shaw, J. Arthur (2013)
Association of elevated urinary concentration of renin-angiotensin system components and severe AKI.Clinical journal of the American Society of Nephrology : CJASN, 8 12
H. Müller, U. Haug, D. Rothenbacher, C. Stegmaier, H. Brenner (2008)
Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancer.The Journal of urology, 180 4
G. Wagener, G. Gubitosa, Shuang Wang, N. Borregaard, Mihwa Kim, H. Lee (2008)
Urinary neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery.American journal of kidney diseases : the official journal of the National Kidney Foundation, 52 3
V. Vaidya, Glen Ford, S. Waikar, Yizhuo Wang, Matthew Clement, V. Ramírez, W. Glaab, Sean Troth, F. Sistare, W. Prozialeck, J. Edwards, N. Bobadilla, Stephen Mefferd, J. Bonventre (2009)
A rapid urine test for early detection of kidney injury.Kidney international, 76 1
Chih-Hsiang Chang, Chia-Hung Yang, Huang-Yu Yang, Tien‐Hsing Chen, Chan‐Yu Lin, Su-wei Chang, Yi-Ting Chen, C. Hung, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen (2015)
Urinary Biomarkers Improve the Diagnosis of Intrinsic Acute Kidney Injury in Coronary Care UnitsMedicine, 94
Fangfang Zhou, Qun Luo, Lailiang Wang, Lina Han (2016)
Diagnostic value of neutrophil gelatinase-associated lipocalin for early diagnosis of cardiac surgery-associated acute kidney injury: a meta-analysis.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 49 3
K. Polderman (2012)
Is therapeutic hypothermia immunosuppressive?Critical Care, 16
J. Wysocki, M. Ye, E. Rodríguez, F. González-Pacheco, C. Barrios, Karla Evora, M. Schuster, H. Loibner, K. Brosnihan, C. Ferrario, J. Penninger, D. Batlle (2010)
Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2: Prevention of Angiotensin II–Dependent HypertensionHypertension, 55
T. Nickolas, M. O’Rourke, Jun Yang, M. Sise, P. Canetta, N. Barasch, C. Buchen, F. Khan, K. Mori, J. Giglio, P. Devarajan, J. Barasch (2008)
Sensitivity and Specificity of a Single Emergency Department Measurement of Urinary Neutrophil GelatinaseAssociated Lipocalin for Diagnosing Acute Kidney InjuryAnnals of Internal Medicine, 148
B. Medić, B. Rovčanin, G. Jovanović, S. Radojevic-Skodric, M. Prostran (2015)
Kidney Injury Molecule-1 and Cardiovascular Diseases: From Basic Science to Clinical PracticeBioMed Research International, 2015
F. Rodier, J. Campisi, D. Bhaumik (2007)
Two faces of p53: aging and tumor suppressionNucleic Acids Research, 35
Am J Physiol Renal Physiol
J. Pajek, A. Škoberne, Klara Šosterič, Barbara Adlešič, B. Leskosek, Maja Pajek, J. Osredkar, J. Lindič (2014)
Non-inferiority of creatinine excretion rate to urinary L-FABP and NGAL as predictors of early renal allograft functionBMC Nephrology, 15
J. Ho, N. Tangri, P. Komenda, Amit Kaushal, M. Sood, R. Brar, K. Gill, Simon Walker, Kerry Macdonald, B. Hiebert, R. Arora, C. Rigatto (2015)
Urinary, Plasma, and Serum Biomarkers' Utility for Predicting Acute Kidney Injury Associated With Cardiac Surgery in Adults: A Meta-analysis.American journal of kidney diseases : the official journal of the National Kidney Foundation, 66 6
J. Alge, N. Karakala, Benjamin Neely, M. Janech, J. Tumlin, L. Chawla, A. Shaw, J. Arthur (2013)
Urinary angiotensinogen and risk of severe AKI.Clinical journal of the American Society of Nephrology : CJASN, 8 2
G. Massolini, E. Calleri (2003)
Survey of binding properties of fatty acid-binding proteins. Chromatographic methods.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 797 1-2
S. Gauer, O. Sichler, N. Obermüller, Y. Holzmann, E. Kiss, E. Sobkowiak, J. Pfeilschifter, H. Geiger, H. Mühl, I. Hauser (2007)
IL-18 is expressed in the intercalated cell of human kidney.Kidney international, 72 9
T. Moriyama, S. Hagihara, T. Shiramomo, M. Nagaoka, Shohei Iwakawa, Y. Kanmura (2016)
Comparison of three early biomarkers for acute kidney injury after cardiac surgery under cardiopulmonary bypassJournal of Intensive Care, 4
F. Seibert, C. Rosenberger, S. Mathia, R. Arndt, W. Arns, Huppertz Andrea, N. Pagonas, F. Bauer, W. Zidek, T. Westhoff (2017)
Urinary Calprotectin Differentiates Between Prerenal and Intrinsic Acute Renal Allograft FailureTransplantation, 101
Valerie Au, Justin Feit, J. Barasch, R. Sladen, G. Wagener (2016)
Urinary Neutrophil Gelatinase–Associated Lipocalin (NGAL) Distinguishes Sustained From Transient Acute Kidney Injury After General SurgeryKidney International Reports, 1
Hui-ling Wu, M. Craft, Peng Wang, K. Wyburn, G. Chen, Jin Ma, B. Hambly, S. Chadban (2008)
IL-18 contributes to renal damage after ischemia-reperfusion.Journal of the American Society of Nephrology : JASN, 19 12
N. Paragas, Ritwij Kulkarni, Max Werth, K. Schmidt-Ott, C. Forster, R. Deng, Qingyin Zhang, Eugenia Singer, A. Klose, T. Shen, K. Francis, Sunetra Ray, S. Vijayakumar, S. Seward, M. Bovino, Katherine Xu, Y. Takabe, Fábio Amaral, S. Mohan, R. Wax, K. Corbin, S. Sanna-Cherchi, K. Mori, L. Johnson, T. Nickolas, V. D’Agati, Chyuan-Sheng Lin, A. Qiu, Q. Al-Awqati, A. Ratner, J. Barasch (2014)
α-Intercalated cells defend the urinary system from bacterial infection.The Journal of clinical investigation, 124 7
J. Arthur, E. Hill, J. Alge, E. Lewis, Benjamin Neely, M. Janech, J. Tumlin, L. Chawla, A. Shaw (2013)
Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgeryKidney international, 85
Guqi Wang, Y. Gong, Judy Anderson, D. Sun, G. Minuk, M. Roberts, F. Burczynski (2005)
Antioxidative function of L‐FABP in L‐FABP stably transfected Chang liver cellsHepatology, 42
Jian-yong Zheng, Yan-yan Xiao, Yong Yao, Guo-bin Xu, Chunying Li, Qi Zhang, Haixia Li, Ling Han (2013)
Comparison of Urinary Biomarkers for Early Detection of Acute Kidney Injury After Cardiopulmonary Bypass Surgery in Infants and Young ChildrenPediatric Cardiology, 34
F. Dieterle, F. Sistare, F. Goodsaid, M. Papaluca, J. Ozer, C. Webb, William Baer, A. Senagore, M. Schipper, J. Vonderscher, S. Sultana, D. Gerhold, J. Phillips, G. Maurer, Kevin Carl, D. Laurie, E. Harpur, M. Sonee, D. Ennulat, D. Holder, Dina Andrews-Cleavenger, Yi-Zhong Gu, K. Thompson, P. Goering, J. Vidal, E. Abadie, R. Mačiulaitis, D. Jacobson-Kram, A. Defelice, E. Hausner, M. Blank, A. Thompson, P. Harlow, D. Throckmorton, S. Xiao, Nancy Xu, W. Taylor, S. Vamvakas, B. Flamion, B. Lima, P. Kasper, M. Pasanen, K. Prasad, Sean Troth, D. Bounous, Denise Robinson-Gravatt, G. Betton, Myrtle Davis, J. Akunda, J. McDuffie, L. Suter, L. Obert, M. Guffroy, Marc Pinches, S. Jayadev, E. Blomme, S. Beushausen, V. Barlow, Nathaniel Collins, Jeffrey Waring, D. Honor, S. Snook, J. Lee, P. Rossi, E. Walker, W. Mattes (2010)
Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing ConsortiumNature Biotechnology, 28
D. Portilla, C. Dent, T. Sugaya, K. Nagothu, I. Kundi, P. Moore, E. Noiri, P. Devarajan (2008)
Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery.Kidney international, 73 4
Rupesh Amin, A. Vickers, F. Sistare, K. Thompson, R. Roman, M. Lawton, J. Kramer, H. Hamadeh, J. Collins, Sherry Grissom, L. Bennett, C. Tucker, S. Wild, C. Kind, V. Oreffo, J. Davis, S. Curtiss, J. Naciff, M. Cunningham, R. Tennant, J. Stevens, B. Car, T. Bertram, C. Afshari (2004)
Identification of putative gene based markers of renal toxicity.Environmental Health Perspectives, 112
J. Brun, T. Madland, J. Gran, G. Myklebust (2005)
A longitudinal study of calprotectin in patients with polymyalgia rheumatica or temporal arteritis: relation to disease activityScandinavian Journal of Rheumatology, 34
T. Flo, Kelly Smith, Shintaro Sato, David Rodriguez, M. Holmes, R. Strong, S. Akira, A. Aderem (2004)
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating ironNature, 432
Chiara Levante, C. Ronco (2016)
The Imperative for Health Economics Assessment in Acute Kidney InjuryBlood Purification, 42
K. Gunnerson, A. Shaw, L. Chawla, A. Bihorac, A. Al-Khafaji, K. Kashani, M. Lissauer, Jing Shi, M. Walker, J. Kellum (2015)
TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patientsThe Journal of Trauma and Acute Care Surgery, 80
K. Kashani, A. Al-Khafaji, T. Ardiles, A. Artigas, Sean Bagshaw, M. Bell, A. Bihorac, R. Birkhahn, Cynthia Cely, L. Chawla, Danielle Davison, T. Feldkamp, L. Forni, M. Gong, K. Gunnerson, M. Haase, J. Hackett, P. Honoré, Eric Hoste, O. Joannes-Boyau, M. Joannidis, P. Kim, J. Koyner, Daniel Laskowitz, Matthew Lissauer, G. Marx, Peter Mccullough, S. Mullaney, M. Ostermann, T. Rimmele, Nathan Shapiro, Andrew Shaw, Jing Shi, Amy Sprague, J. Vincent, C. Vinsonneau, L. Wagner, Michael Walker, R Wilkerson, K. Zacharowski, J. Kellum (2013)
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injuryCritical Care, 17
F. Seibert, N. Pagonas, R. Arndt, F. Heller, D. Dragun, P. Persson, K. Schmidt-Ott, W. Zidek, T. Westhoff (2013)
Calprotectin and neutrophil gelatinase–associated lipocalin in the differentiation of pre‐renal and intrinsic acute kidney injuryActa Physiologica, 207
T. Ichimura, J. Bonventre, V. Bailly, Henry Wei, C. Hession, R. Cate, M. Sanicola (1998)
Kidney Injury Molecule-1 (KIM-1), a Putative Epithelial Cell Adhesion Molecule Containing a Novel Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury*The Journal of Biological Chemistry, 273
Am J Physiol Renal Physiol, 286
D. Payen, A. Lukaszewicz, I. Bélikova, V. Faivre, C. Gélin, S. Rußwurm, J. Launay, N. Sevenet (2008)
Gene profiling in human blood leucocytes during recovery from septic shockIntensive Care Medicine, 34
W. Han, V. Bailly, R. Abichandani, R. Thadhani, J. Bonventre (2002)
Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury.Kidney international, 62 1
Vincent Wu, Che-Hsiung Wu, Tao‐Min Huang, Cheng-Yi Wang, Chun-Fu Lai, C. Shiao, Chia-Hsui Chang, Shuei-Liong Lin, Yen-Yuan Chen, Yung-Ming Chen, T. Chu, W. Chiang, K. Wu, P. Tsai, Likwang Chen, W. Ko (2014)
Long-term risk of coronary events after AKI.Journal of the American Society of Nephrology : JASN, 25 3
O. Ismail, Xizhong Zhang, Junjun Wei, A. Haig, B. Denker, R. Suri, A. Şener, L. Gunaratnam (2015)
Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury.The American journal of pathology, 185 5
R. Schrier (2010)
Early intervention in acute kidney injuryNature Reviews Nephrology, 6
C. Dent, Q. Ma, Sudha Dastrala, M. Bennett, M. Mitsnefes, J. Barasch, P. Devarajan (2007)
Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort studyCritical Care, 11
S. Coca, R. Yalavarthy, J. Concato, C. Parikh (2008)
Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review.Kidney international, 73 9
V. Melnikov, Tevfik Ecder, G. Fantuzzi, Britta Siegmund, M. Lucia, C. Dinarello, Robert Schrier, Charles Edelstein (2001)
Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure.The Journal of clinical investigation, 107 9
B. Medić, B. Rovčanin, K. Vujović, D. Obradovic, Dusan Duric, M. Prostran (2016)
Evaluation of Novel Biomarkers of Acute Kidney Injury: The Possibilities and Limitations.Current medicinal chemistry, 23 19
Xinghua Shao, L. Tian, Weijia Xu, Zhen Zhang, Chunlin Wang, Chao-jun Qi, Z. Ni, S. Mou (2014)
Diagnostic Value of Urinary Kidney Injury Molecule 1 for Acute Kidney Injury: A Meta-AnalysisPLoS ONE, 9
P. Devarajan (2007)
Emerging biomarkers of acute kidney injury.Contributions to nephrology, 156
Chunbo Chen, Xiaobing Yang, Ying Lei, Y. Zha, Huafeng Liu, Changsheng Ma, Jianwei Tian, Pingyan Chen, Tiecheng Yang, F. Hou (2016)
Urinary Biomarkers at the Time of AKI Diagnosis as Predictors of Progression of AKI among Patients with Acute Cardiorenal Syndrome.Clinical journal of the American Society of Nephrology : CJASN, 11 9
Crit Care (London, England), 8
S. Supavekin, Weijia Zhang, R. Kucherlapati, F. Kaskel, L. Moore, P. Devarajan (2003)
Differential gene expression following early renal ischemia/reperfusion.Kidney international, 63 5
H. Geus, J. Bakker, E. Lesaffre, J. Noble (2011)
Neutrophil gelatinase-associated lipocalin at ICU admission predicts for acute kidney injury in adult patients.American journal of respiratory and critical care medicine, 183 7
Nandkishor Chindarkar, L. Chawla, J. Straseski, S. Jortani, D. Uettwiller-Geiger, R. Orr, J. Kellum, R. Fitzgerald (2016)
Reference intervals of urinary acute kidney injury (AKI) markers [IGFBP7]∙[TIMP2] in apparently healthy subjects and chronic comorbid subjects without AKI.Clinica chimica acta; international journal of clinical chemistry, 452
Eugenia Singer, L. Markó, N. Paragas, J. Barasch, D. Dragun, D. Müller, K. Budde, K. Schmidt-Ott, K. Schmidt-Ott (2013)
Neutrophil gelatinase‐associated lipocalin: pathophysiology and clinical applicationsActa Physiologica, 207
K. Schmidt-Ott, K. Mori, Jau-yi Li, A. Kalandadze, D. Cohen, P. Devarajan, J. Barasch (2007)
Dual action of neutrophil gelatinase-associated lipocalin.Journal of the American Society of Nephrology : JASN, 18 2
M. Dessing, A. Tammaro, W. Pulskens, Gwendoline Teske, L. Butter, N. Claessen, M. Eijk, T. Poll, T. Vogl, J. Roth, S. Florquin, J. Leemans (2015)
The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion.Kidney international, 87 1
Aashish Sharma, Marìa Mucino, C. Ronco (2014)
Renal Functional Reserve and Renal Recovery after Acute Kidney InjuryNephron Clinical Practice, 127
J. Koyner, A. Garg, S. Coca, K. Sint, H. Thiessen-Philbrook, U. Patel, M. Shlipak, C. Parikh (2012)
Biomarkers predict progression of acute kidney injury after cardiac surgery.Journal of the American Society of Nephrology : JASN, 23 5
R. Maatman, T. Kuppevelt, J. Veerkamp (1991)
Two types of fatty acid-binding protein in human kidney. Isolation, characterization and localization.The Biochemical journal, 273 ( Pt 3)
P. Susantitaphong, M. Siribamrungwong, Kent Doi, E. Noiri, N. Terrin, B. Jaber (2013)
Performance of urinary liver-type fatty acid-binding protein in acute kidney injury: a meta-analysis.American journal of kidney diseases : the official journal of the National Kidney Foundation, 61 3
Xiaobing Yang, Chunbo Chen, Jianwei Tian, Y. Zha, Yuqin Xiong, Zhaolin Sun, Pingyan Chen, Jun Li, Tie-cheng Yang, Changsheng Ma, Huafeng Liu, Xiaobin Wang, F. Hou (2015)
Urinary Angiotensinogen Level Predicts AKI in Acute Decompensated Heart Failure: A Prospective, Two-Stage Study.Journal of the American Society of Nephrology : JASN, 26 8
Ralph Witzgall, Dennis Brown, Cordula Schwarz, Joseph Bonventre (1994)
Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.The Journal of clinical investigation, 93 5
T. Pianta, P. Peake, J. Pickering, M. Kelleher, N. Buckley, Z. Endre (2015)
Clusterin in Kidney Transplantation: Novel Biomarkers Versus Serum Creatinine for Early Prediction of Delayed Graft FunctionTransplantation, 99
K. Damman, S. Masson, H. Hillege, A. Maggioni, A. Voors, C. Opasich, D. Veldhuisen, L. Montagna, F. Cosmi, G. Tognoni, L. Tavazzi, R. Latini (2011)
Clinical outcome of renal tubular damage in chronic heart failure.European heart journal, 32 21
N. Imai, T. Yasuda, A. Kamijo-Ikemori, Y. Shibagaki, K. Kimura (2015)
Distinct Roles of Urinary Liver-Type Fatty Acid-Binding Protein in Non-Diabetic Patients with AnemiaPLoS ONE, 10
Van Timmeren, M. Heuvel, V. Bailly, S. Bakker, V. Goor, C. Stegeman (2007)
Tubular kidney injury molecule‐1 (KIM‐1) in human renal diseaseThe Journal of Pathology, 212
D. Foell, H. Wittkowski, Z. Ren, J. Turton, Gerald Pang, J. Daebritz, Jan Ehrchen, J. Heidemann, T. Borody, Johannes Roth, R. Clancy (2008)
Phagocyte‐specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel diseaseThe Journal of Pathology, 216
Valérie Pennemans, J. Rigo, C. Faes, C. Reynders, J. Penders, Q. Swennen (2013)
Establishment of reference values for novel urinary biomarkers for renal damage in the healthy population: are age and gender an issue?, 51
S. Bagshaw, R. Bellomo (2007)
Early diagnosis of acute kidney injuryCurrent Opinion in Critical Care, 13
J. Ebbing, S. Mathia, F. Seibert, N. Pagonas, F. Bauer, Barbara Erber, K. Günzel, E. Kilic, C. Kempkensteffen, K. Miller, A. Bachmann, C. Rosenberger, W. Zidek, T. Westhoff (2014)
Urinary calprotectin: a new diagnostic marker in urothelial carcinoma of the bladderWorld Journal of Urology, 32
V. Bailly, Zhiwei Zhang, W. Meier, R. Cate, M. Sanicola, J. Bonventre (2002)
Shedding of Kidney Injury Molecule-1, a Putative Adhesion Protein Involved in Renal Regeneration*The Journal of Biological Chemistry, 277
Juan Du, Xiaoqing Cao, L. Zou, Yi Chen, Jin Guo, Zujun Chen, Shengshou Hu, Zhe Zheng (2013)
MicroRNA-21 and Risk of Severe Acute Kidney Injury and Poor Outcomes after Adult Cardiac SurgeryPLoS ONE, 8
E. Aguado-Fraile, E. Ramos, E. Conde, Macarena Rodríguez, Laura Martín-Gómez, A. Lietor, A. Candela, B. Ponte, F. Liaño, M. García-Bermejo (2015)
A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney InjuryPLoS ONE, 10
Jian-dong Zhang, Nathan Rudemiller, Mehul Patel, Qingqing Wei, Norah Karlovich, Alexander Jeffs, Min Wu, M. Sparks, J. Privratsky, Marcela Herrera, S. Gurley, S. Nedospasov, S. Crowley (2016)
Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI.Journal of the American Society of Nephrology : JASN, 27 8
H. Szerlip, L. Chawla (2016)
Predicting acute kidney injury prognosisCurrent Opinion in Nephrology and Hypertension, 25
J. Mishra, K. Mori, Q. Ma, C. Kelly, J. Barasch, P. Devarajan (2004)
Neutrophil Gelatinase-Associated Lipocalin: A Novel Early Urinary Biomarker for Cisplatin NephrotoxicityAmerican Journal of Nephrology, 24
R. Morgenstern, Per-Johan Jakobsson, A. Ulloa-Aguirre, J. Ito, J. Janovick, H. Kobori, L. Navar, A. Nishiyama (2007)
The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney DiseasePharmacological Reviews, 59
A. Odutayo, Christopher Wong, M. Farkouh, D. Altman, S. Hopewell, C. Emdin, Benjamin Hunn (2017)
AKI and Long-Term Risk for Cardiovascular Events and Mortality.Journal of the American Society of Nephrology : JASN, 28 1
R. Smathers, D. Petersen (2011)
The human fatty acid-binding protein family: Evolutionary divergences and functionsHuman Genomics, 5
Ravi Ghatanatti, Anita Teli, S. Tirkey, S. Bhattacharya, G. Sengupta, A. Mondal (2014)
Role of renal biomarkers as predictors of acute kidney injury in cardiac surgeryAsian Cardiovascular and Thoracic Annals, 22
M. James, C. Hobson, M. Darmon, S. Mohan, D. Hudson, S. Goldstein, C. Ronco, J. Kellum, S. Bagshaw (2016)
Applications for detection of acute kidney injury using electronic medical records and clinical information systems: workgroup statements from the 15th ADQI Consensus ConferenceCanadian Journal of Kidney Health and Disease, 3
C. Krawczeski, S. Goldstein, J. Woo, Yu Wang, N. Piyaphanee, Q. Ma, M. Bennett, P. Devarajan (2011)
Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass.Journal of the American College of Cardiology, 58 22
Grace Smith, J. Lichtman, M. Bracken, M. Shlipak, C. Phillips, P. DiCapua, H. Krumholz (2006)
Renal impairment and outcomes in heart failure: systematic review and meta-analysis.Journal of the American College of Cardiology, 47 10
D. Nakano, H. Kobori, James Burford, H. Gevorgyan, S. Seidel, H. Hitomi, A. Nishiyama, J. Peti-Peterdi (2012)
Multiphoton imaging of the glomerular permeability of angiotensinogen.Journal of the American Society of Nephrology : JASN, 23 11
Eva Schrezenmeier, Eva Schrezenmeier, J. Barasch, K. Budde, T. Westhoff, K. Schmidt-Ott, Kai Schmidt-Ott (2017)
Biomarkers in acute kidney injury – pathophysiological basis and clinical performanceActa Physiologica, 219
S. Nisula, R. Yang, M. Poukkanen, S. Vaara, K. Kaukonen, M. Tallgren, M. Haapio, J. Tenhunen, A. Korhonen, V. Pettilä, R. Laru-Sompa, Anni Pulkkinen, M. Saarelainen, Mikko Reilama, Sinikka Tolmunen, Ulla Rantalainen, M. Miettinen, M. Suvela, Katrine Pesola, Pekka Saastamoinen, Sirpa Kauppinen, V. Pettilä, K. Kaukonen, A. Korhonen, S. Nisula, S. Vaara, R. Suojaranta-Ylinen, L. Mildh, M. Haapio, L. Nurminen, S. Sutinen, Leena Pettilä, H. Laitinen, H. Syrjä, Kirsi Henttonen, Elina Lappi, H. Boman, T. Varpula, P. Porkka, Mira Rahkonen, Anne Tsurkka, Taina Nieminen, Niina Prittinen, A. Alaspää, Ville Salanto, Hanna Juntunen, Teija Sanisalo, I. Parviainen, A. Uusaro, E. Ruokonen, S. Bendel, Niina Rissanen, Maarit Lång, S. Rahikainen, Saija Rissanen, M. Ahonen, Elina Halonen, Eija Vaskelainen, M. Poukkanen, Esa Lintula, Sirpa Suominen, J. Heikkinen, Timo Lavander, Kirsi Heinonen, A. Juopperi, T. Kamiński, F. Gäddnäs, Tuija Kuusela, Jane Roiko, S. Karlsson, M. Reinikainen, Tero Surakka, Helena Jyrkönen, Tanja Eiserbeck, Jaana Kallinen, V. Lund, P. Tuominen, Pauliina Perkola, Riikka Tuominen, Marika Hietaranta, Satu Johansson, S. Hovilehto, A. Kirsi, P. Tiainen, Tuija Myllärinen, Pirjo Leino, Anne Toropainen, A. Kuitunen, I. Leppänen, Markus Levoranta, S. Hoppu, Jukka Sauranen, J. Tenhunen, A. Kukkurainen, S. Kortelainen, S. Varila, Outi Inkinen, N. Koivuviita, Jutta Kotamäki, A. Laine, T. Ala-Kokko, J. Laurila, Sinikka Sälkiö, Simo-Pekka Koivisto, R. Hautamäki, Maria Skinnar (2015)
Predictive value of urine interleukin-18 in the evolution and outcome of acute kidney injury in critically ill adult patients.British journal of anaesthesia, 114 3
T. Fuchs, Katharina Frick, B. Emde, S. Czasch, F. Landenberg, P. Hewitt (2012)
Evaluation of Novel Acute Urinary Rat Kidney Toxicity Biomarker for Subacute Toxicity Studies in Preclinical TrialsToxicologic Pathology, 40
H. Hammer, S. Ødeg̊ard, M. Fagerhol, R. Landewé, D. Heijde, T. Uhlig, P. Mowinckel, T. Kvien (2007)
Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritisAnnals of the Rheumatic Diseases, 66
J. Charlton, D. Portilla, M. Okusa (2014)
A basic science view of acute kidney injury biomarkers.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29 7
W. Prozialeck, Vishal Vaidya, Jie Liu, M. Waalkes, J. Edwards, P. Lamar, Alfred Bernard, X. Dumont, Joseph Bonventre, Joseph Bonventre (2007)
Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity.Kidney international, 72 8
N. Tan, N. Shaw, N. Vinckenbosch, P. Liu, R. Yasmin, B. Desvergne, W. Wahli, N. Noy (2002)
Selective Cooperation between Fatty Acid Binding Proteins and Peroxisome Proliferator-Activated Receptors in Regulating TranscriptionMolecular and Cellular Biology, 22
C. Ronco (2013)
Kidney Attack: Overdiagnosis of Acute Kidney Injury or Comprehensive Definition of Acute Kidney Syndromes?Blood Purification, 36
I. Gocze, M. Koch, P. Renner, F. Zeman, B. Graf, M. Dahlke, M. Nerlich, H. Schlitt, J. Kellum, T. Bein (2015)
Urinary Biomarkers TIMP-2 and IGFBP7 Early Predict Acute Kidney Injury after Major SurgeryPLoS ONE, 10
Takeshi Yokoyama, A. Kamijo-Ikemori, T. Sugaya, Seiko Hoshino, T. Yasuda, K. Kimura (2009)
Urinary excretion of liver type fatty acid binding protein accurately reflects the degree of tubulointerstitial damage.The American journal of pathology, 174 6
J Leukoc Biol, 73
L. Altwegg, M. Neidhart, M. Hersberger, S. Müller, F. Eberli, R. Corti, M. Roffi, G. Sütsch, S. Gay, A. Eckardstein, M. Wischnewsky, T. Lüscher, W. Maier (2007)
Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes.European heart journal, 28 8
C. Thongprayoon, W. Cheungpasitporn, K. Kashani (2016)
Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients.Journal of thoracic disease, 8 5
T. Nickolas, K. Schmidt-Ott, P. Canetta, C. Forster, Eugenia Singer, M. Sise, Antje Elger, O. Maarouf, D. Valle, M. O’Rourke, E. Sherman, Peter Lee, A. Geara, Philip Imus, A. Guddati, A. Polland, W. Rahman, S. Elitok, N. Malik, J. Giglio, S. El‐Sayegh, P. Devarajan, S. Hebbar, S. Saggi, B. Hahn, R. Kettritz, F. Luft, J. Barasch (2012)
Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study.Journal of the American College of Cardiology, 59 3
L. Chawla, P. Eggers, R. Star, P. Kimmel (2014)
Acute kidney injury and chronic kidney disease as interconnected syndromes.The New England journal of medicine, 371 1
J. Mishra, Q. Ma, A. Prada, M. Mitsnefes, K. Zahedi, Jun Yang, J. Barasch, P. Devarajan (2003)
Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury.Journal of the American Society of Nephrology : JASN, 14 10
R. Murugan, X. Wen, N. Shah, Minjae Lee, L. Kong, F. Pike, Christopher Keener, M. Unruh, Kevin Finkel, A. Vijayan, P. Palevsky, E. Paganini, M. Carter, M. Elder, J. Kellum (2014)
Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29 10
M. Hazle, R. Gajarski, R. Aiyagari, Sunkyung Yu, Abin Abraham, Janet Donohue, N. Blatt (2013)
Urinary biomarkers and renal near-infrared spectroscopy predict intensive care unit outcomes after cardiac surgery in infants younger than 6 months of age.The Journal of thoracic and cardiovascular surgery, 146 4
C. Ronco, J. Kellum, M. Haase (2012)
Subclinical AKI is still AKICritical Care, 16
N. Katz, C. Ronco (2015)
Acute kidney stress—a useful term based on evolution in the understanding of acute kidney injuryCritical Care, 20
J. Koyner, D. Davison, E. Brasha-Mitchell, Divya Chalikonda, J. Arthur, A. Shaw, J. Tumlin, S. Trevino, M. Bennett, P. Kimmel, M. Seneff, L. Chawla (2015)
Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity.Journal of the American Society of Nephrology : JASN, 26 8
Eunjung Cho, Ha Yang, S. Jo, W. Cho, Hyoung-Kyu Kim (2013)
The Role of Urinary Liver-Type Fatty Acid-Binding Protein in Critically Ill PatientsJournal of Korean Medical Science, 28
J. Ehrchen, C. Sunderkötter, D. Foell, T. Vogl, J. Roth (2009)
The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancerJournal of Leukocyte Biology, 86
AbstractAcute kidney injury (AKI) is a common complication of critical illnesses and has a significant impact on outcomes, including mortality and morbidities. Unfortunately, apart from prophylactic measures, no effective treatment for this syndrome is known. Therefore, early recognition of AKI not only can provide better opportunities for preventive interventions, but also opens many gates for research and development of effective therapeutic options. Over the last few years, several new AKI biomarkers have been discovered and validated to improve early detection, differential diagnosis, and differentiation of patients into risk groups for progressive renal failure, need for renal replacement therapy (RRT), or death. These novel AKI biomarkers complement serum creatinine (SCr) and urine output, which are the standard diagnostic tools for AKI detection. In this article, we review the available literature on characteristics of promising AKI biomarkers that are currently the focus of preclinical and clinical investigations. These biomarkers include neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM-1), liver-type fatty acid-binding protein, interleukin 18 (lL-18), insulin-like growth factor-binding protein 7, tissue inhibitor of metalloproteinase 2 (TIMP-2), calprotectin, urine angiotensinogen (AGT), and urine microRNA. We then describe the clinical performance of these biomarkers for diagnosis and prognostication. We also appraise each AKI biomarker’s advantages and limitations as a tool for early AKI recognition and prediction of clinical outcomes after AKI. Finally, we review the current and future states of implementation of biomarkers in the clinical practice.
Clinical Chemistry and Laboratory Medicine (CCLM) – de Gruyter
Published: Jul 26, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.