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Association between chronic pain and the sperm motion characteristics

Association between chronic pain and the sperm motion characteristics 48 Abstracts / Scandinavian Journal of Pain 8 (2015) 47–54 by which those interviewed aided us to find other prospective Conclusions: This study demonstrated that chronic pain does interviewee. In qualitative methodology, such an approach can be not affect the sperm morphology, total concentration and motil- adopted to enable the researcher acquire relevant data with help ity based on conventional analysis but has significant influence from respondents. Practitioners were asked to reflect on their expe- at the level of sperm motion kinetics which could prove to be clinically valuable, prognostic indicators of successful fertilization. riences from meeting women with severe pain as their patients. Seven practitioners, four female and three male, were interviewed. Maturation of sperm motility occurs during their transit through Results: By talking spontaneously about pain, women cope with the epididymis and vas deferens regulated by androgens. As male painful disorders. This ensures easy diagnoses and treatments. The gonadal hormones have an inhibitory, adaptive effect on the behav- majority of women report their severe pain disabilities freely as ioral and neuronal responses to repeated nociceptive stimulation, against a smaller group who behave differently. The other group has it can be speculated that the observed difference in sperm kine- explored other practitioners and have been unsuccessful. They are matic parameters could be related to the alterations in serum sex afraid to reveal their situations openly. Others test the skills of the hormone levels emanating from the chronic pain. Further studies practitioners whether they could perform efficient diagnoses. This are required to explain the possible mechanism of action of chronic strengthens patients’ faith and ability to be cured. In behavioural pain on male fertility. terms, inability to report severe pain stem from comorbid http://dx.doi.org/10.1016/j.sjpain.2015.04.006 depressive symptoms (timidity-shyness, over-worried/confusion, distraction), lack of trust-expectant faith, thought of practitioner’s omniscient power, threat of practitioner’s knowledge (patient’s Spontaneous burrowing behavior as an wrongs and evil thoughts), religious affiliation-constraints, etc. outcome measure of the global impact of Women cope and show more positive attitudes than men; they chronic pain in preclinical models of arthritis expect practitioners to be in careful control. A. Delaney , J. Su, T. Gao, N. Agalave, C.I. Svensson Conclusions: Ghanaian women deal with their severe pains in meaningful manner by talking spontaneously about them. They Department of Physiology and Pharmacology, show their willingness to be helped during diagnosis. Only few Karolinska Institutet, Stockholm, Sweden patients are not spontaneous, and are due to the condition of the E-mail address: ada.delaney@ki.se (A. Delaney). mind and uncertainty with previous treatment encounters. Aims: Arthritis is the leading cause of chronic pain in Euro- pean adults (painineurope.com). Arthritis-induced chronic pain is http://dx.doi.org/10.1016/j.sjpain.2015.04.005 a major clinical problem that is frequently inadequately treated by current analgesics and results in significant reduction in the Association between chronic pain and the patient’s quality of life. Outcome measures used in pain research sperm motion characteristics to assess injury-induced pain-like behaviours in preclinical mod- els are often dependent on the assessment of withdrawal reflexes, a,b,c,∗ a a F. Dardmeh , H. Alipour , H.I. Nielsen ,S. typically evoked by mechanical or thermal stimuli. Advances in pre- c a a Rasmussen , J.T. Yousefi , N.E. Ditlevsen , a a a dictive validity may be improved by assessing the global impact H.A.A.K.T. Yassin , E. Morina , R.K. Duus ,P. of pain and the reinstatement of innate behaviours suppressed by a,b Gazerani injury. Burrowing, an indicator of the global “wellbeing” of the ani- Department of Health Science and Technology, mal can be objectively measured. We aimed to assess the impact Biomedicine Group, Faculty of Medicine, Aalborg of several preclinical models of arthritis on burrowing behaviour in University, Aalborg, Denmark mice. Center for Sensory – Motor Interaction (SMI), Methods: The collagen antibody-induced arthritis (CAIA) pre- Department of Health Science and Technology, clinical model of rheumatoid arthritis, the complete Freund’s Faculty of Medicine, Aalborg University, Aalborg, adjuvant (CFA), monosodium iodoacetate (MIA) and partial medial Denmark menisectomy (MMT) preclinical models of osteoarthritis were Department of Clinical Medicine, The Faculty of assessed in female and/or male C57/Black6J adult mice, comparing Medicine, Aalborg University Hospital, Aalborg, to control (saline or sham-operated) and naïve animals. Mechanical Denmark hypersensitivity using von Frey filaments and spontaneous bur- E-mail address: feda@hst.aau.dk (F. Dardmeh). rowing behaviour were assessed over 60 days (CAIA), 14 days (CFA), 28 days (MIA) and up to 200 days (MMT). Aims: Sex hormones play an important role in pain in many Results: We show the development of mechanical hypersen- chronic pain conditions. Relationship between chronic pain and sitivity in all preclinical models of arthritis, whereas spontaneous sperm quality has not been investigated thoroughly and may burrowing behaviour was altered differently between the preclin- provide an insight to better understanding, management and ical models. A deficit in burrowing behaviour was observed in treatment of cases where chronic pain and male sub-fertility the preclinical models of osteoarthritis and a gain in burrowing co-exist. behaviour noted in the preclinical model of rheumatoid arthritis, Methods: Neat (fresh semen) and processed sperm from 15 with no effect seen in the CFA model. males with orthopedic chronic pain (CP) were assessed and com- Conclusions: Burrowing behaviour appears more sensitive to pared with 15 healthy age matched controls. Sperm analysis was detecting variation in preclinical models of arthritis when com- performed using the SCA computer-aided sperm analyzer. pared to mechanical hypersensitivity. Burrowing behaviour can Results: There was no significant difference in any parameters detect both gain and deficits in the behaviour, which differs of the neat semen between the pain and control group. However between preclinical models of rheumatoid and osteoarthritis. the percentage of non-progressive motile spermatozoa (type B) Acknowledgments: Research support from Ulla & Gustaf af was significantly higher in the pain group (27.96) compared to Uggles Foundation; KI Foundation; Swedish Foundation for Strate- the control group (15.96). Straight line trajectories including lin- gic Research; GLORIA (FP7) European Research Council. earity, straightness, wobble and beat cross frequency were also significantly higher in the processed sample of the CP group. http://dx.doi.org/10.1016/j.sjpain.2015.04.007 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

Association between chronic pain and the sperm motion characteristics

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Publisher
de Gruyter
Copyright
© 2015 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
DOI
10.1016/j.sjpain.2015.04.006
Publisher site
See Article on Publisher Site

Abstract

48 Abstracts / Scandinavian Journal of Pain 8 (2015) 47–54 by which those interviewed aided us to find other prospective Conclusions: This study demonstrated that chronic pain does interviewee. In qualitative methodology, such an approach can be not affect the sperm morphology, total concentration and motil- adopted to enable the researcher acquire relevant data with help ity based on conventional analysis but has significant influence from respondents. Practitioners were asked to reflect on their expe- at the level of sperm motion kinetics which could prove to be clinically valuable, prognostic indicators of successful fertilization. riences from meeting women with severe pain as their patients. Seven practitioners, four female and three male, were interviewed. Maturation of sperm motility occurs during their transit through Results: By talking spontaneously about pain, women cope with the epididymis and vas deferens regulated by androgens. As male painful disorders. This ensures easy diagnoses and treatments. The gonadal hormones have an inhibitory, adaptive effect on the behav- majority of women report their severe pain disabilities freely as ioral and neuronal responses to repeated nociceptive stimulation, against a smaller group who behave differently. The other group has it can be speculated that the observed difference in sperm kine- explored other practitioners and have been unsuccessful. They are matic parameters could be related to the alterations in serum sex afraid to reveal their situations openly. Others test the skills of the hormone levels emanating from the chronic pain. Further studies practitioners whether they could perform efficient diagnoses. This are required to explain the possible mechanism of action of chronic strengthens patients’ faith and ability to be cured. In behavioural pain on male fertility. terms, inability to report severe pain stem from comorbid http://dx.doi.org/10.1016/j.sjpain.2015.04.006 depressive symptoms (timidity-shyness, over-worried/confusion, distraction), lack of trust-expectant faith, thought of practitioner’s omniscient power, threat of practitioner’s knowledge (patient’s Spontaneous burrowing behavior as an wrongs and evil thoughts), religious affiliation-constraints, etc. outcome measure of the global impact of Women cope and show more positive attitudes than men; they chronic pain in preclinical models of arthritis expect practitioners to be in careful control. A. Delaney , J. Su, T. Gao, N. Agalave, C.I. Svensson Conclusions: Ghanaian women deal with their severe pains in meaningful manner by talking spontaneously about them. They Department of Physiology and Pharmacology, show their willingness to be helped during diagnosis. Only few Karolinska Institutet, Stockholm, Sweden patients are not spontaneous, and are due to the condition of the E-mail address: ada.delaney@ki.se (A. Delaney). mind and uncertainty with previous treatment encounters. Aims: Arthritis is the leading cause of chronic pain in Euro- pean adults (painineurope.com). Arthritis-induced chronic pain is http://dx.doi.org/10.1016/j.sjpain.2015.04.005 a major clinical problem that is frequently inadequately treated by current analgesics and results in significant reduction in the Association between chronic pain and the patient’s quality of life. Outcome measures used in pain research sperm motion characteristics to assess injury-induced pain-like behaviours in preclinical mod- els are often dependent on the assessment of withdrawal reflexes, a,b,c,∗ a a F. Dardmeh , H. Alipour , H.I. Nielsen ,S. typically evoked by mechanical or thermal stimuli. Advances in pre- c a a Rasmussen , J.T. Yousefi , N.E. Ditlevsen , a a a dictive validity may be improved by assessing the global impact H.A.A.K.T. Yassin , E. Morina , R.K. Duus ,P. of pain and the reinstatement of innate behaviours suppressed by a,b Gazerani injury. Burrowing, an indicator of the global “wellbeing” of the ani- Department of Health Science and Technology, mal can be objectively measured. We aimed to assess the impact Biomedicine Group, Faculty of Medicine, Aalborg of several preclinical models of arthritis on burrowing behaviour in University, Aalborg, Denmark mice. Center for Sensory – Motor Interaction (SMI), Methods: The collagen antibody-induced arthritis (CAIA) pre- Department of Health Science and Technology, clinical model of rheumatoid arthritis, the complete Freund’s Faculty of Medicine, Aalborg University, Aalborg, adjuvant (CFA), monosodium iodoacetate (MIA) and partial medial Denmark menisectomy (MMT) preclinical models of osteoarthritis were Department of Clinical Medicine, The Faculty of assessed in female and/or male C57/Black6J adult mice, comparing Medicine, Aalborg University Hospital, Aalborg, to control (saline or sham-operated) and naïve animals. Mechanical Denmark hypersensitivity using von Frey filaments and spontaneous bur- E-mail address: feda@hst.aau.dk (F. Dardmeh). rowing behaviour were assessed over 60 days (CAIA), 14 days (CFA), 28 days (MIA) and up to 200 days (MMT). Aims: Sex hormones play an important role in pain in many Results: We show the development of mechanical hypersen- chronic pain conditions. Relationship between chronic pain and sitivity in all preclinical models of arthritis, whereas spontaneous sperm quality has not been investigated thoroughly and may burrowing behaviour was altered differently between the preclin- provide an insight to better understanding, management and ical models. A deficit in burrowing behaviour was observed in treatment of cases where chronic pain and male sub-fertility the preclinical models of osteoarthritis and a gain in burrowing co-exist. behaviour noted in the preclinical model of rheumatoid arthritis, Methods: Neat (fresh semen) and processed sperm from 15 with no effect seen in the CFA model. males with orthopedic chronic pain (CP) were assessed and com- Conclusions: Burrowing behaviour appears more sensitive to pared with 15 healthy age matched controls. Sperm analysis was detecting variation in preclinical models of arthritis when com- performed using the SCA computer-aided sperm analyzer. pared to mechanical hypersensitivity. Burrowing behaviour can Results: There was no significant difference in any parameters detect both gain and deficits in the behaviour, which differs of the neat semen between the pain and control group. However between preclinical models of rheumatoid and osteoarthritis. the percentage of non-progressive motile spermatozoa (type B) Acknowledgments: Research support from Ulla & Gustaf af was significantly higher in the pain group (27.96) compared to Uggles Foundation; KI Foundation; Swedish Foundation for Strate- the control group (15.96). Straight line trajectories including lin- gic Research; GLORIA (FP7) European Research Council. earity, straightness, wobble and beat cross frequency were also significantly higher in the processed sample of the CP group. http://dx.doi.org/10.1016/j.sjpain.2015.04.007

Journal

Scandinavian Journal of Painde Gruyter

Published: Jul 1, 2015

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