48Abstracts / Scandinavian Journal of Pain 8 (2015) 47–54by which those interviewed aided us to ﬁnd other prospectiveinterviewee. In qualitative methodology, such an approach can beadopted to enable the researcher acquire relevant data with helpfrom respondents. Practitioners were asked to reﬂect on their experiences from meeting women with severe pain as their patients.Seven practitioners, four female and three male, were interviewed.Results: By talking spontaneously about pain, women cope withpainful disorders. This ensures easy diagnoses and treatments. Themajority of women report their severe pain disabilities freely asagainst a smaller group who behave differently. The other group hasexplored other practitioners and have been unsuccessful. They areafraid to reveal their situations openly. Others test the skills of thepractitioners whether they could perform efﬁcient diagnoses. Thisstrengthens patients’ faith and ability to be cured. In behaviouralterms, inability to report severe pain stem from comorbiddepressive symptoms (timidity-shyness, over-worried/confusion,distraction), lack of trust-expectant faith, thought of practitioner’somniscient power, threat of practitioner’s knowledge (patient’swrongs and evil thoughts), religious afﬁliation-constraints, etc.Women cope and show more positive attitudes than men; theyexpect practitioners to be in careful control.Conclusions: Ghanaian women deal with their severe pains inmeaningful manner by talking spontaneously about them. Theyshow their willingness to be helped during diagnosis. Only fewpatients are not spontaneous, and are due to the condition of themind and uncertainty with previous treatment encounters.http://dx.doi.org/10.1016/j.sjpain.2015.04.005Association between chronic pain and thesperm motion characteristicsF. Dardmeh a,b,c,∗ , H. Alipour a , H.I. Nielsen a , S.Rasmussen c , J.T. Youseﬁ a , N.E. Ditlevsen a ,H.A.A.K.T. Yassin a , E. Morina a , R.K. Duus a , P.Gazerani a,baDepartment of Health Science and Technology,Biomedicine Group, Faculty of Medicine, AalborgUniversity, Aalborg, Denmarkb Center for Sensory – Motor Interaction (SMI),Department of Health Science and Technology,Faculty of Medicine, Aalborg University, Aalborg,Denmarkc Department of Clinical Medicine, The Faculty ofMedicine, Aalborg University Hospital, Aalborg,DenmarkE-mail address: email@example.com (F. Dardmeh).Aims: Sex hormones play an important role in pain in manychronic pain conditions. Relationship between chronic pain andsperm quality has not been investigated thoroughly and mayprovide an insight to better understanding, management andtreatment of cases where chronic pain and male sub-fertilityco-exist.Methods: Neat (fresh semen) and processed sperm from 15males with orthopedic chronic pain (CP) were assessed and compared with 15 healthy age matched controls. Sperm analysis wasperformed using the SCA computer-aided sperm analyzer.Results: There was no signiﬁcant difference in any parametersof the neat semen between the pain and control group. Howeverthe percentage of non-progressive motile spermatozoa (type B)was signiﬁcantly higher in the pain group (27.96) compared tothe control group (15.96). Straight line trajectories including linearity, straightness, wobble and beat cross frequency were alsosigniﬁcantly higher in the processed sample of the CP group.Conclusions: This study demonstrated that chronic pain doesnot affect the sperm morphology, total concentration and motility based on conventional analysis but has signiﬁcant inﬂuenceat the level of sperm motion kinetics which could prove to beclinically valuable, prognostic indicators of successful fertilization.Maturation of sperm motility occurs during their transit throughthe epididymis and vas deferens regulated by androgens. As malegonadal hormones have an inhibitory, adaptive effect on the behavioral and neuronal responses to repeated nociceptive stimulation,it can be speculated that the observed difference in sperm kinematic parameters could be related to the alterations in serum sexhormone levels emanating from the chronic pain. Further studiesare required to explain the possible mechanism of action of chronicpain on male fertility.http://dx.doi.org/10.1016/j.sjpain.2015.04.006Spontaneous burrowing behavior as anoutcome measure of the global impact ofchronic pain in preclinical models of arthritisA. Delaney ∗ , J. Su, T. Gao, N. Agalave, C.I. SvenssonDepartment of Physiology and Pharmacology,Karolinska Institutet, Stockholm, SwedenE-mail address: firstname.lastname@example.org (A. Delaney).Aims: Arthritis is the leading cause of chronic pain in European adults (painineurope.com). Arthritis-induced chronic pain isa major clinical problem that is frequently inadequately treatedby current analgesics and results in signiﬁcant reduction in thepatient’s quality of life. Outcome measures used in pain researchto assess injury-induced pain-like behaviours in preclinical models are often dependent on the assessment of withdrawal reﬂexes,typically evoked by mechanical or thermal stimuli. Advances in predictive validity may be improved by assessing the global impactof pain and the reinstatement of innate behaviours suppressed byinjury. Burrowing, an indicator of the global “wellbeing” of the animal can be objectively measured. We aimed to assess the impactof several preclinical models of arthritis on burrowing behaviour inmice.Methods: The collagen antibody-induced arthritis (CAIA) preclinical model of rheumatoid arthritis, the complete Freund’sadjuvant (CFA), monosodium iodoacetate (MIA) and partial medialmenisectomy (MMT) preclinical models of osteoarthritis wereassessed in female and/or male C57/Black6J adult mice, comparingto control (saline or sham-operated) and naïve animals. Mechanicalhypersensitivity using von Frey ﬁlaments and spontaneous burrowing behaviour were assessed over 60 days (CAIA), 14 days (CFA),28 days (MIA) and up to 200 days (MMT).Results: We show the development of mechanical hypersensitivity in all preclinical models of arthritis, whereas spontaneousburrowing behaviour was altered differently between the preclinical models. A deﬁcit in burrowing behaviour was observed inthe preclinical models of osteoarthritis and a gain in burrowingbehaviour noted in the preclinical model of rheumatoid arthritis,with no effect seen in the CFA model.Conclusions: Burrowing behaviour appears more sensitive todetecting variation in preclinical models of arthritis when compared to mechanical hypersensitivity. Burrowing behaviour candetect both gain and deﬁcits in the behaviour, which differsbetween preclinical models of rheumatoid and osteoarthritis.Acknowledgments: Research support from Ulla & Gustaf afUggles Foundation; KI Foundation; Swedish Foundation for Strategic Research; GLORIA (FP7) European Research Council.http://dx.doi.org/10.1016/j.sjpain.2015.04.007
Scandinavian Journal of Pain – de Gruyter
Published: Jul 1, 2015
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