Antioxidant capacity in patients with type 2 diabetes: a preliminary investigation on gender-specific differences in an Italian population

Antioxidant capacity in patients with type 2 diabetes: a preliminary investigation on... To the Editor,Men and women differences are important in epidemiology, pathophysiology and treatment of type 2 diabetes mellitus (DM2). On the other hand, international position statements on diabetes care do not provide specific recommendations for females, except in the case of pregnant women [1].This is staggering if we think that women with DM2 carry 40% greater relative risk of coronary heart disease compared with men. The full explanation of the increased cardiovascular risk in diabetic women is far from being completely understood and many biological factors could be involved, like oxidative stress and antioxidant status.Chronic inflammation, together with oxidative stress, is a pivotal factor in the development of DM2 and the progression of vascular complications [2]. Moreover, in DM2, a specific impairment in antioxidant capacity has been well described [3]. It is important to go in depth in the association between gender and oxidative stress because oxidative stress is crucial in many diseases that differently affect males and females, DM2 and atherosclerosis in particular. Recently, gender differences in antioxidant enzyme subunits’ expression have been described, together with a different activity of these enzymes, between males and females [4]. Although these studies have been mainly performed on animal or in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine (CCLM) de Gruyter

Antioxidant capacity in patients with type 2 diabetes: a preliminary investigation on gender-specific differences in an Italian population

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Publisher
de Gruyter
Copyright
©2018 Walter de Gruyter GmbH, Berlin/Boston
ISSN
1437-4331
eISSN
1437-4331
D.O.I.
10.1515/cclm-2017-0721
Publisher site
See Article on Publisher Site

Abstract

To the Editor,Men and women differences are important in epidemiology, pathophysiology and treatment of type 2 diabetes mellitus (DM2). On the other hand, international position statements on diabetes care do not provide specific recommendations for females, except in the case of pregnant women [1].This is staggering if we think that women with DM2 carry 40% greater relative risk of coronary heart disease compared with men. The full explanation of the increased cardiovascular risk in diabetic women is far from being completely understood and many biological factors could be involved, like oxidative stress and antioxidant status.Chronic inflammation, together with oxidative stress, is a pivotal factor in the development of DM2 and the progression of vascular complications [2]. Moreover, in DM2, a specific impairment in antioxidant capacity has been well described [3]. It is important to go in depth in the association between gender and oxidative stress because oxidative stress is crucial in many diseases that differently affect males and females, DM2 and atherosclerosis in particular. Recently, gender differences in antioxidant enzyme subunits’ expression have been described, together with a different activity of these enzymes, between males and females [4]. Although these studies have been mainly performed on animal or in

Journal

Clinical Chemistry and Laboratory Medicine (CCLM)de Gruyter

Published: Mar 28, 2018

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