In this issue of the Scandinavian Journal of Pain, Menzer et al.  report on the spatial components of a nerve branch block induced by two different doses of mepivacaine, a short acting local anesthetic. Apart from an obvious difference on duration of the block by two different concentrations administered, 5 mg/ml and 10 mg/ml, and in the spatial extension of the block, there were also some differences between different sensory modalities.In spite of the long time that local anesthetics have been available, there are very few studies describing the differential effects of local anesthetics, i.e. unselective sodium channel blockers, on specific, different sensory modalities. This is true for temporal and spatial components. Previous studies have focused mainly on graded levels of motor block and on dicotomous yes/no assessments of “surgical anesthesia”.1Neuropathic pain and sodium channels NaV1.7, NaV1.8, and NaV1.9In light of the high interest during the latter years in the role of the different sodium channels, both NaV1.7, recently also NaV1.8, and possibly even NaV1.9, in neuropathic pain, this type of knowledge is of great importance. This is not only for the understanding of neuropathic pain per se, but also as a tool for the development of new
Scandinavian Journal of Pain – de Gruyter
Published: Apr 1, 2013
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