A novel approach of analyzing characteristics of sensory nerve fibers

A novel approach of analyzing characteristics of sensory nerve fibers In this issue of the Scandinavian Journal of Pain, Menzer et al. [1] report on the spatial components of a nerve branch block induced by two different doses of mepivacaine, a short acting local anesthetic. Apart from an obvious difference on duration of the block by two different concentrations administered, 5 mg/ml and 10 mg/ml, and in the spatial extension of the block, there were also some differences between different sensory modalities.In spite of the long time that local anesthetics have been available, there are very few studies describing the differential effects of local anesthetics, i.e. unselective sodium channel blockers, on specific, different sensory modalities. This is true for temporal and spatial components. Previous studies have focused mainly on graded levels of motor block and on dicotomous yes/no assessments of “surgical anesthesia”.1Neuropathic pain and sodium channels NaV1.7, NaV1.8, and NaV1.9In light of the high interest during the latter years in the role of the different sodium channels, both NaV1.7, recently also NaV1.8, and possibly even NaV1.9, in neuropathic pain, this type of knowledge is of great importance. This is not only for the understanding of neuropathic pain per se, but also as a tool for the development of new http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Pain de Gruyter

A novel approach of analyzing characteristics of sensory nerve fibers

Loading next page...
 
/lp/degruyter/a-novel-approach-of-analyzing-characteristics-of-sensory-nerve-fibers-fHVqKvUWuC
Publisher
De Gruyter
Copyright
© 2012 Scandinavian Association for the Study of Pain
ISSN
1877-8860
eISSN
1877-8879
D.O.I.
10.1016/j.sjpain.2012.12.001
Publisher site
See Article on Publisher Site

Abstract

In this issue of the Scandinavian Journal of Pain, Menzer et al. [1] report on the spatial components of a nerve branch block induced by two different doses of mepivacaine, a short acting local anesthetic. Apart from an obvious difference on duration of the block by two different concentrations administered, 5 mg/ml and 10 mg/ml, and in the spatial extension of the block, there were also some differences between different sensory modalities.In spite of the long time that local anesthetics have been available, there are very few studies describing the differential effects of local anesthetics, i.e. unselective sodium channel blockers, on specific, different sensory modalities. This is true for temporal and spatial components. Previous studies have focused mainly on graded levels of motor block and on dicotomous yes/no assessments of “surgical anesthesia”.1Neuropathic pain and sodium channels NaV1.7, NaV1.8, and NaV1.9In light of the high interest during the latter years in the role of the different sodium channels, both NaV1.7, recently also NaV1.8, and possibly even NaV1.9, in neuropathic pain, this type of knowledge is of great importance. This is not only for the understanding of neuropathic pain per se, but also as a tool for the development of new

Journal

Scandinavian Journal of Painde Gruyter

Published: Dec 29, 2017

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off