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Visualization of Tissue Kallikrein in Human Breast Carcinoma by Two-Dimensional Western Blotting and Immunohistochemistry

Visualization of Tissue Kallikrein in Human Breast Carcinoma by Two-Dimensional Western Blotting... Introduction Tumour proliferation, invasion, and metastasis have been proposed to be facilitated by proteinases degrading the components of the extracellular matrix. The so-called metastatic cascade consists of a sequence of steps in which several proteinases may play a crucial role, for example, urokinase-type plasminogen activator, collagenase and other matrix metalloproteinases and their inhibitors (TIMP), and the lysosomal proteinases Cathepsin D, B and L. All these enzymes are able to degrade basement membranes. Some of them, such as cathepsin D and urokinase-type plasminogen activator, have been shown to be of prognostic relevance in breast cancer (Khokka ef a/., 1991; Rochefort, 1992; Schmitt etal., 1990). More recent studies were also performed on the involvement of tissue kallikrein in malignant diseases, showing that tissue kallikrein is secreted by gastric carcinoma cells (Koshikawa et a/., 1992) and that specific inhibitors of tissue kallikrein can influence metastasis of Lewis lung tumour cells (Uetsuji et a/., 1992). In healthy man, tissue kallikrein is present in salivary glands, saliva, pancreas, kidney, urine, small and large intestine, endometrium, and in low concentrations in blood (Bhoola etal., 1992; Clements and Mukhtar, 1994;Witzgall Results By immunohistochemistry 27 malignant breast tumours were examined for the presence of tissue kallikrein. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biological Chemistry Hoppe-Seyler de Gruyter

Visualization of Tissue Kallikrein in Human Breast Carcinoma by Two-Dimensional Western Blotting and Immunohistochemistry

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Publisher
de Gruyter
Copyright
Copyright © 1995 by the
ISSN
0177-3593
eISSN
1437-4315
DOI
10.1515/bchm3.1995.376.6.365
Publisher site
See Article on Publisher Site

Abstract

Introduction Tumour proliferation, invasion, and metastasis have been proposed to be facilitated by proteinases degrading the components of the extracellular matrix. The so-called metastatic cascade consists of a sequence of steps in which several proteinases may play a crucial role, for example, urokinase-type plasminogen activator, collagenase and other matrix metalloproteinases and their inhibitors (TIMP), and the lysosomal proteinases Cathepsin D, B and L. All these enzymes are able to degrade basement membranes. Some of them, such as cathepsin D and urokinase-type plasminogen activator, have been shown to be of prognostic relevance in breast cancer (Khokka ef a/., 1991; Rochefort, 1992; Schmitt etal., 1990). More recent studies were also performed on the involvement of tissue kallikrein in malignant diseases, showing that tissue kallikrein is secreted by gastric carcinoma cells (Koshikawa et a/., 1992) and that specific inhibitors of tissue kallikrein can influence metastasis of Lewis lung tumour cells (Uetsuji et a/., 1992). In healthy man, tissue kallikrein is present in salivary glands, saliva, pancreas, kidney, urine, small and large intestine, endometrium, and in low concentrations in blood (Bhoola etal., 1992; Clements and Mukhtar, 1994;Witzgall Results By immunohistochemistry 27 malignant breast tumours were examined for the presence of tissue kallikrein.

Journal

Biological Chemistry Hoppe-Seylerde Gruyter

Published: Jan 1, 1995

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