Introduction Tumour proliferation, invasion, and metastasis have been proposed to be facilitated by proteinases degrading the components of the extracellular matrix. The so-called metastatic cascade consists of a sequence of steps in which several proteinases may play a crucial role, for example, urokinase-type plasminogen activator, collagenase and other matrix metalloproteinases and their inhibitors (TIMP), and the lysosomal proteinases Cathepsin D, B and L. All these enzymes are able to degrade basement membranes. Some of them, such as cathepsin D and urokinase-type plasminogen activator, have been shown to be of prognostic relevance in breast cancer (Khokka ef a/., 1991; Rochefort, 1992; Schmitt etal., 1990). More recent studies were also performed on the involvement of tissue kallikrein in malignant diseases, showing that tissue kallikrein is secreted by gastric carcinoma cells (Koshikawa et a/., 1992) and that specific inhibitors of tissue kallikrein can influence metastasis of Lewis lung tumour cells (Uetsuji et a/., 1992). In healthy man, tissue kallikrein is present in salivary glands, saliva, pancreas, kidney, urine, small and large intestine, endometrium, and in low concentrations in blood (Bhoola etal., 1992; Clements and Mukhtar, 1994;Witzgall Results By immunohistochemistry 27 malignant breast tumours were examined for the presence of tissue kallikrein.
Biological Chemistry Hoppe-Seyler – de Gruyter
Published: Jan 1, 1995
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