Althabe et al., Transfcrence of para-amino-hippurate j. Perinat. Med. 4 (1976) 227 0. Althabe,G.Sabini,A.Basso,A.Fernändez, D. Torrado,R. Belitzky, R. CaldeyroBarcia Latin American Center for Perinatology and Human Development (PAHO/WHO), Department of Physiopathology, Medical Faculty, Montevideo, Uruguay To our knowledge there are few studies which analyze the time course of the concentration in amniotic fluid of alien substances administered to women during pregnancy. This is particularly true for those substances mainly cleared by the kidney into the urine. HANON et al.  gave orally para-amino-hippurate (PAH) to mothers during labor and found that about two hours later, the concentration of PAH in amniotic fluid was higher than that of maternal plasma. BRANDES et al.  showed that inulin passed from the mother to the fetus during late pregnancy but ROSA  administering this substance to the mother, could not find it in serial samples of amniotic fluid. Recently BASSO et al.  demonstrated that mannitol administered to the mother appears in amniotic fluid atincreasingconcentrationsreaching values higher than those found in simultaneous samples of maternal plasma. This type of studies may contribute to the knowledge of fetal renal function and its role in the formation of amniotic fluid, äs well äs
Journal of Perinatal Medicine – de Gruyter
Published: Jan 1, 1976
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