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Isolated are being increasingly used in drug metabolism studies since they possess many of the attributes of both in vitrq and in vivo systems. This paper reviews recent work on this use of isolated , with particular emphasis on their value in the study of (a) species and organ differences in xenobiotic metabolism, (b) the relation of metabolism to toxicity and (c) the balance of Phase I/Phase II metabolism. INTRODUCTION A major feature of the in vivo metabolism of most drugs and other xenobiotics is the wide range of metabolites that are produced. As our knowledge of the mechanisms underlying the reactions involved in these metabolic pathways has increased considerably over the last twenty years, largely by use of homogenate fractions obtained from liver (the major site of metabolism) and other organs, so a need has arisen to "synthesize" this knowledge to investigate the factors involved in control of these various metabolic pathways and also to assay the response of the intact cell to metabolites produced from these xenobiotics. It is in these areas that the isolated hepatocyte system is a particularly useful tool, as it combines both the inherent simplicity of all in vitro systems and the
Drug Metabolism and Drug Interactions – de Gruyter
Published: Sep 1, 1982
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