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THE METABOLISM AND BIOPHARMACEUTICS OF SPIRONOLACTONE IN MAN Hans WP.M. Overdiek1, and Frans W.H.M. Merkus2. Clinical Pharmacokinetics and Toxicology Laboratory, Hospital of Sittard, Walramstraat 23, 6131 BK Sittard, The Netherlands. Center for Bio-Pharmaceutical Sciences, University of Leiden, P.O. Box 9502, 2300 RA Leiden, The Netherlands. Dr. J.W.P.M. Overdiek is currently at the Central Pharmacy of t h e Hague Hospitals, P.O.Box 4 3 1 0 0 , 2 5 0 4 A C , T h e Hague, The Netherlands. Correspondence concerning this review should be directed to Professor F.W.H.M. Merkus. CONTENTS SUMMARY I II III IV INTRODUCTION BIOTRANSFORMATION ASSAY METHODS R E C O V E R Y OF RADIOACTIVITY A F T E R LACTONE ADMINISTRATION V PHARMACOKINETICS OF S P I R O N O L A C T O N E SUBJECTS IN HEALTHY 279 20-[ 3 H]-SPIRONO278 Page 274 274 275 278 5.1 Blood compartment a) single dose studies b) multiple dose studies 5.2 Urinary excretion data 5.3 Faeces 5.4 Biliary excretion 5.5 Conclusion VI VII VIII PHARMACOKINETIC STUDIES IN PATIENTS PHARMACOKINETIC STUDIES IN T H E E L D E R L Y BIOAVAILABILITY 8.1 Effect of food on bioavailability 8.2 Influence
Drug Metabolism and Drug Interactions – de Gruyter
Published: Sep 1, 1987
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