Introduction D-Penicillamine ()3,j3'-dimethylcysteine) is used in human therapy for an increasing number of diseases. The mechanisms whereby this interesting substance exerts its various therapeutic actions, are, however, not always fully understood. There is increasing interest iii the changes in enzymatic activities evoked by D-penicillamine. Biochemically, D-penicillamine acts as a chelating agent (e. g. ehelatioh of copper ions in Wilson's disease), splits disulfide bonds (exchange reactions), and reacts with aldehyde groups (e. g r with aldehyde groups of pyridoxal-phosphate and tropocollagen). Important enzymes and enzyme systems may be influenced by £>-penicillamine via all three-of the above mechanisms. So far, an anti-collagenase effect of jD-penicillainine has been reported (1) as well as an inhibitory action oft alkaline phosphataSe activity (2). The latter effect was attributable to a chelation of important ions. In further investigations, changes in glucose-6-phosphate dehydrogenase activity were encountered under the J. Clin. Chem. Clin. Biochem. / Vol. 14,1976 / No. 4 influence of £)-penicillamine. As a contribution to the various biochemical actions of /)-penicillamine, the results of these studies will be reported here. Methods and Materials Enzyme sources: Glucose-6-phosphate dehydrogenase (EC 188.8.131.52) activity has been investigated from three sources: from yeast (pure enzyme preparation, commercially available), from
Clinical Chemistry and Laboratory Medicine – de Gruyter
Published: Jan 1, 1976
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