Hoppe-Seyler's Z. Physiol. Chem. Bd. 357, S. 107 - 116, Januar 1976 The Conformational Potential of Porcine Proinsulin C-Peptide* Hans-Peter VOGT, Axel WOLLMER, Vinod K. NAITHANI and Helmut ZAHN Fachgebiet Struktur und Funktion der Proteine, Abte ung Physiologische Chemie, Technische Hochschule Aachen Deutsches Wollforschungsinstitut, Aachen (Received 20 October 1975) Summary: Statistical analysis of protein sequences lends itself to the identification of regions with a definite inclination to adopt specific main-chain conformations. Application of the model of Chou and Fasmant1'2! to porcine proinsulin C-peptide localizes the tendency to form a helix in the segments (38 to 44) and (51 to 58). A tendency to turn formation is predicted for the segment (45 to 50). The realization of this conformational potential under native and various other conditions was examined by CD spectroscopy. Synthetic C-peptide as well as the synthetic fragments (33 - 40), (41 - 52), (41 - 61), (46 - 52), (46 - 61), aiid (53-61) were included in the study. These fragments provide breaks in the amino acid sequence in each of the potentially ordered regions. The strong helical tendency in the (51 - 58) segment can be activated in the fragments (41 - 61) and (46 -
hoppe-seyler's zeitschrift für physiologische chemie – de Gruyter
Published: Jan 1, 1976
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera