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THE APPLICATION OF MONOCLONAL ANTIBODIES FOR STUDIES ON CYTOCHROME P 4 5 0 Fred. K. Friedman, Sang S. Park and Harry V. Gelboin Laboratory of Molecular Carcinogenesis National Cancer Institute Bethesda, Maryland 20205 CONTENTS Page 1. INTRODUCTION 2. MONOCLONAL ANTIBODIES 160 161 a. The Origin and Nature of Monoclonal Antibodies b. Monoclonal antibodies to Cytochrome P-450. 3. INHIBITION OF CATALYTIC ACTIVITY BY MONOCLONAL ANTIBODIES Reaction Phenotyping of Substrate Specificity Reaction Phenotyping of Product Specificity Reaction Phenotyping of Human Cytochrome P-450 Cytochrome P-450 Catalyzed Protein and DNA Adduct Formation, Toxicity, Mutagenicity, and Carcinogenicity e. Regulation of Cytochrome P-450 Expression under Different Nutritional Conditions f . Cytochrome P-450 Expression in Cell Culture 4. RADIOIMMUNOASSAY WITH MONOCLONAL ANTIBODIES 5. IMMUNOPURIFICATION USING MONOCLONAL ANTIBODIES 6. SUMMARY AND PERSPECTIVES a. b. c. d. Abbreviations References 0334-2190/85/02&3-0159-192@$.30/pg. © by Freund Publishing House, Ltd. Vol. 5, No. 2& 3, 1985 1. INTRODUCTION The mixed f u n c t i o n oxygenase system metabolizes n u m e r o u s exogenous and endogenous c o m p o u n d s in higher organisms. These include xenobiotics such as drugs, carcinogens, and environmental pollutants as well as endobiotics such as steroids
Drug Metabolism and Drug Interactions – de Gruyter
Published: Jun 1, 1985
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