Studies on the Concentration of Arsenic, Selenium, Copper, Zinc and Iron in the Blood of Blackfoot Disease Patients in Different Clinical Stages

Studies on the Concentration of Arsenic, Selenium, Copper, Zinc and Iron in the Blood of... Introduction An endemic peripheral vascular disease called blackfoot disease is suffered by a large number of inhabitants on the southwest coast of Taiwan (1 --6). The disease has an insidious onset with numbness or coldness as the initial symptom. It progresses with the development of localized ulceration and subsequent gangrenous changes, giving the characteristic black coloration of dry gangrene. Most patients are permanently maimed as a result of spontaneous or artificial amputation of a portion of the affected extremity (7). Blackfoot disease is thought to be related to the presence in artesian drinking water of high concentrations of arsenic, silicate, copper, nickel and certain fluorescent compounds, with arsenic as the primary suspect (8-18). Patients with advanced clinical symptoms should therefore have a high concentration of blood arsenic, but our preliminary results showed a decrease of Eur. J. Clin. Chem. Clin. Biochem. / Vol. 31,1993 / No. 11 arsenic in the advanced stages. In order to assess this situation, we determined arsenic, iron, selenium, zinc and copper in blood samples from blackfoot disease patients in different clinical stages. The results indicate a probable antagonistic effect between arsenic and selenium. Materials and Methods Blood samples One hundred and thirteen blood http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Studies on the Concentration of Arsenic, Selenium, Copper, Zinc and Iron in the Blood of Blackfoot Disease Patients in Different Clinical Stages

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1993.31.11.759
Publisher site
See Article on Publisher Site

Abstract

Introduction An endemic peripheral vascular disease called blackfoot disease is suffered by a large number of inhabitants on the southwest coast of Taiwan (1 --6). The disease has an insidious onset with numbness or coldness as the initial symptom. It progresses with the development of localized ulceration and subsequent gangrenous changes, giving the characteristic black coloration of dry gangrene. Most patients are permanently maimed as a result of spontaneous or artificial amputation of a portion of the affected extremity (7). Blackfoot disease is thought to be related to the presence in artesian drinking water of high concentrations of arsenic, silicate, copper, nickel and certain fluorescent compounds, with arsenic as the primary suspect (8-18). Patients with advanced clinical symptoms should therefore have a high concentration of blood arsenic, but our preliminary results showed a decrease of Eur. J. Clin. Chem. Clin. Biochem. / Vol. 31,1993 / No. 11 arsenic in the advanced stages. In order to assess this situation, we determined arsenic, iron, selenium, zinc and copper in blood samples from blackfoot disease patients in different clinical stages. The results indicate a probable antagonistic effect between arsenic and selenium. Materials and Methods Blood samples One hundred and thirteen blood

Journal

Clinical Chemistry and Laboratory Medicinede Gruyter

Published: Jan 1, 1993

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