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L. Hollis, A. Amundsen, E. Stern (1989)
Chemical and biological properties of a new series of cis-diammineplatinum(II) antitumor agents containing three nitrogen donors: cis-[Pt(NH3)2(N-donor)Cl]+.Journal of medicinal chemistry, 32 1
R. Safirstein, Jonathan Winston, D. Moel, S. Dikman, J. Guttenplan (1987)
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R. Goldstein, G. Mayor (1983)
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E. Lempers, M. Bloemink, J. Reedijk (1991)
Reaction products of [Pt(ethylenediamine)(dimethyl sulfoxide)Cl]Cl and [Pt(ethylenediamine)Cl2] with d(GpG) and 5'GMP. Unambiguous evidence for stable 1:1 intermediate N7 adducts with coordinated dimethyl sulfoxideInorganic Chemistry, 30
STUDIES ON cis-DDP, [Pt(Dach)(MePhSO)Cl]+ AND [Pt(NH 3 ) 2 (N-Py)Clf BINDING TO FUMARASE Güler Yalgin University of Marmara, Faculty of Pharmacy, Department of Analytical Chemistry, 81010 Haydarpa$a, Istanbul, Turkey SUMMARY Two platinum analogs which have suitable physical properties and show antineoplastic activities comparable or greater than that obtained with c/s-DDP were synthesized: [c/s-Pt A 2 (Am) CI] N 0 3 and [Pt (dach) (RR'SO) CI] NO3 (A: ammonia, Am: pyridine, dach: transdiaminocyclohexane, RR'SO: methylphenylsulphoxide). Their interactions with fumarase were studied. Tlie inhibition of fumarase activity by the platinum compounds was followed kinetically by a spectrophotometric method. These two platinum compounds generally inhibited fumarase less than cm-DDP at the concentrators and reaction media (phosphate buffer or NaCl-buffer) studied. KEY WORDS c/s-dichlorodiamineplatinum(II), [Pt(MePhSOXdiaminocyclohexane) CI] N 0 3 , cw-[Pt(NH 3 ) 2 (pyridine)Cl]N03, iumarase, inhibition INTRODUCTION The square planar complex c/s-dichlorodiammineplatinum (cisDDP) (I) is an antineoplastic drug with proven effectiveness against numerous animal and human tumors III. Despite significant antineoplastic activity, its clinical use is limited due to severe side effects /2,3/, especially nephrotoxicity. The mechanism underlying the nephrotoxicity and other side effects is unclear /3-5/. Recently two cationic classes of platinum compounds were described which showed activity in primary
Drug Metabolism and Drug Interactions – de Gruyter
Published: Jun 1, 1995
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