Hoppe-Seyler's Z. Physiol. Chem. Bd. 357, S. 1637 - 1646, November 1976 Studies of the Ligand Binding to Cholera Toxin, I The Lipophilic Moiety of Sialoglycolipids* Herbert WIEGANDT, Wolfgang ZIEGLER, Joseph STAERK, Theodor KRANZ, Hans Jörg RONNEBERGER, Harald ZILG, Karl-Anders KARLSSON and Bengt E. SAMUELSSON Physiologisch Chemisches Institut I der Universität Marburg, Behringwerke AG, Marburg Dept. of Medical Biochemistry, University of Göteborg (Received 12 July 1976) Summary: The fixation of cholera toxin by ganglioside G G tetl is dependent on the nature of the carbohydrate as well as the lipid moiety of the glycolipid. The role of the lipid in binding to the toxin was investigated with synthetic ganglioside analogues (gangliosidoides). The interaction between glycolipid and toxin was followed by precipitate formation, by inhibition of toxicity and in polyacrylamide gel electrophoresis. For specific precipitation, an aliphatic hydrocarbon chain at least 14 C-atoms in length is required. Some of the gangliosidoides form high molecular weight complexes with cholera toxin at lower molar ratios of ligand to protein than the natural compound. None of the synthetic gangliosidoides equalled natural ganglioside in its ability to inhibit the effects of the toxin in vivo, but some did show considerable inhibitory activity in
hoppe-seyler's zeitschrift für physiologische chemie – de Gruyter
Published: Jan 1, 1976
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