Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Toffolo, F. Grandi, C. Cobelli (1995)
Estimation of β-Cell Sensitivity From Intravenous Glucose Tolerance Test C-Peptide Data: Knowledge of the Kinetics Avoids Errors in Modeling the SecretionDiabetes, 44
C. Bouchard, R. Savard, J. Després, A. Tremblay, C. Leblanc (1985)
Body composition in adopted and biological siblings.Human biology, 57 1
B. Landau, J. Wahren, V. Chandramouli, W. Schumann, K. Ekberg, S. Kalhan (1996)
Contributions of gluconeogenesis to glucose production in the fasted state.The Journal of clinical investigation, 98 2
Cynthia Ogden, M. Carroll, L. Curtin, M. McDowell, Carolyn Tabak, K. Flegal (2006)
Prevalence of overweight and obesity in the United States, 1999-2004.JAMA, 295 13
F. Bacha, Rola Saad, N. Gungor, J. Janosky, S. Arslanian (2003)
Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors.The Journal of clinical endocrinology and metabolism, 88 6
L. Gillis, L. Kennedy, Am Gillis, Oded Bar-Or (2002)
Relationship between juvenile obesity, dietary energy and fat intake and physical activityInternational Journal of Obesity, 26
J. Swanson, D. Laine, W. Thomas, J. Bantle (1992)
Metabolic effects of dietary fructose in healthy subjects.The American journal of clinical nutrition, 55 4
A. Mcgloin, M. Livingstone, L. Greene, S. Webb, Jma Gibson, S. Jebb, T. Cole, W. Coward, A. Wright, A. Prentice (2002)
Energy and fat intake in obese and lean children at varying risk of obesityInternational Journal of Obesity, 26
Sharon Elliott, N. Keim, J. Stern, K. Teff, P. Havel (2002)
Fructose, weight gain, and the insulin resistance syndrome.The American journal of clinical nutrition, 76 5
S. Reiser, J. Hallfrisch (1977)
Insulin sensitivity and adipose tissue weight of rats fed starch or sucrose diets ad libitum or in meals.The Journal of nutrition, 107 1
Arefaine Abraha, Sandy Humphreys, M. Clark, David Matthews, K. Frayn (1998)
Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjectsBritish Journal of Nutrition, 80
M. Chen, R. Bergman, D. Porte (1988)
Insulin Resistance and β-Cell Dysfunction in Aging: The Importance of Dietary CarbohydrateThe Journal of Clinical Endocrinology and Metabolism, 67
M. Treuth, A. Sunehag, L. Trautwein, D. Bier, M. Haymond, N. Butte (2003)
Metabolic adaptation to high-fat and high-carbohydrate diets in children and adolescents.The American journal of clinical nutrition, 77 2
J. Bantle, J. Swanson, W. Thomas, D. Laine (1992)
Metabolic Effects of Dietary Fructose in Diabetic SubjectsDiabetes Care, 15
E. Jéquier (2001)
Is fat intake a risk factor for fat gain in children?The Journal of clinical endocrinology and metabolism, 86 3
V. Koivisto, H. Yki-Järvinen (1993)
Fructose and insulin sensitivity in patients with type 2 diabetesJournal of Internal Medicine, 233
Barbara Gower, T. Nagy, M. Goran (1999)
Visceral fat, insulin sensitivity, and lipids in prepubertal children.Diabetes, 48 8
R. Hoffman, P. Armstrong (1996)
Glucose effectiveness, peripheral and hepatic insulin sensitivity, in obese and lean prepubertal children.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 20 6
M. Albrink, I. Ullrich (1986)
Interaction of dietary sucrose and fiber on serum lipids in healthy young men fed high carbohydrate diets.The American journal of clinical nutrition, 43 3
J. Guthrie, J. Morton (2000)
Food sources of added sweeteners in the diets of Americans.Journal of the American Dietetic Association, 100 1
A. Avogaro, J. Bristow, D. Bier, C. Cobelli, G. Toffolo (1989)
Stable-Label Intravenous Glucose Tolerance Test Minimal ModelDiabetes, 38
A. Sunehag, G. Toffolo, M. Treuth, N. Butte, C. Cobelli, D. Bier, M. Haymond (2002)
Effects of dietary macronutrient content on glucose metabolism in children.The Journal of clinical endocrinology and metabolism, 87 11
C. Proserpi, A. Sparti, Yves Schutz, V. Vetta, Hubert Milon, E. Jéquier (1997)
Ad libitum intake of a high-carbohydrate or high-fat diet in young men: effects on nutrient balances.The American journal of clinical nutrition, 66 3
A. Thorburn, L. Storlien, A. Jenkins, S. Khouri, Edward WKraegen (1989)
Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats.The American journal of clinical nutrition, 49 6
M. Goran (2001)
Metabolic precursors and effects of obesity in children: a decade of progress, 1990-1999.The American journal of clinical nutrition, 73 2
Stephen Cook, M. Weitzman, P. Auinger, Michael Nguyen, W. Dietz (2003)
Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994.Archives of pediatrics & adolescent medicine, 157 8
R. Andersen, C. Crespo, C. Crespo, S. Bartlett, L. Cheskin, M. Pratt (1998)
Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.JAMA, 279 12
D. Ludwig, K. Peterson, S. Gortmaker (2001)
Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysisThe Lancet, 357
A. Sunehag, G. Toffolo, M. Campioni, D. Bier, M. Haymond (2005)
Effects of dietary macronutrient intake on insulin sensitivity and secretion and glucose and lipid metabolism in healthy, obese adolescents.The Journal of clinical endocrinology and metabolism, 90 8
P. Havel (2005)
Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.Nutrition reviews, 63 5
G. Bray, S. Nielsen, B. Popkin (2004)
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity.The American journal of clinical nutrition, 79 4
D. Faeh, K. Minehira, J. Schwarz, Raj Periasamy, Seongsu Park, L. Tappy (2005)
Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men.Diabetes, 54 7
O. Pinhas‐Hamiel, L. Dolan, S. Daniels, D. Standiford, P. Khoury, P. Zeitler (1996)
Increased incidence of non-insulin-dependent diabetes mellitus among adolescents.The Journal of pediatrics, 128 5 Pt 1
M. Daly (2003)
Sugars, insulin sensitivity, and the postprandial state.The American journal of clinical nutrition, 78 4
J. Bantle, S. Raatz, W. Thomas, A. Georgopoulos (2000)
Effects of dietary fructose on plasma lipids in healthy subjects.The American journal of clinical nutrition, 72 5
J. Schwarz, R. Neese, S. Turner, D. Dare, M. Hellerstein (1995)
Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection.The Journal of clinical investigation, 96 6
W Dietz (2001)
Overweight and precursors of type 2 diabetes mellitus in children and adolescents.The Journal of pediatrics, 138 4
H. Beck-Nielsen, O. Pedersen, H. Lindskov (1980)
Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects.The American journal of clinical nutrition, 33 2
K. Teff, Sharon Elliott, M. Tschöp, T. Kieffer, Daniel Rader, M. Heiman, R. Townsend, N. Keim, D. D’Alessio, P. Havel (2004)
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.The Journal of clinical endocrinology and metabolism, 89 6
A. Rosenbloom, J. Joe, R. Young, W. Winter (1999)
Emerging epidemic of type 2 diabetes in youth.Diabetes care, 22 2
INTRODUCTION There is virtually no information on the metabolic impact of dietary fructose intake in adolescents despite their consumption, particularly via sweetened beverages. Aim: To determine the short-term metabolic effects of dietary fructose intake in obese adolescents. Methods: Six volunteers (3 M/3 F; 15.2 ± 0.5 yr; 35 ± 2 kg/mz; 39 ± 2% body fat) were studied twice following 7 d of isocaloric, isonitrogenous high carbohydrate (60% CHO; 25% fat) diets with fructose accounting for 6% and 24% of total energy intake, respectively (random order). Insulin sensitivity and secretion were analyzed by the stable labeled intravenous glucose tolerance test and glucose and lipid kinetics using GCMS. Results: A fourfold increase in dietary fructose intake did not affect insulin sensitivity or secretion, glucose kinetics, lipolysis or glucose, insulin, C-peptide, triglycerides, HDL- and LDL-cholesterol concentrations. Conclusions: In the short term, when energy intake is constant, dietary fructose per se is not a contributor to insulin resistance and hypersecretion in obese adolescents. KEY WORDS fructose, glucose production, gluconeogenesis, insulin sensitivity, insulin secretion, stable isotopes Reprint address: Agneta L. Sunehag, M.D., Ph.D. Children's Nutrition Research Center 1100 Bates Street Houston, TX 77030, USA e-mail: asunehag@bcm.tmc.edu VOLUME 21, NO. 3 , 2
Journal of Pediatric Endocrinology and Metabolism – de Gruyter
Published: Mar 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.