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Short-term High Dietary Fructose Intake had No Effects on Insulin Sensitivity and Secretion or Glucose and Lipid Metabolism in Healthy, Obese Adolescents

Short-term High Dietary Fructose Intake had No Effects on Insulin Sensitivity and Secretion or... INTRODUCTION There is virtually no information on the metabolic impact of dietary fructose intake in adolescents despite their consumption, particularly via sweetened beverages. Aim: To determine the short-term metabolic effects of dietary fructose intake in obese adolescents. Methods: Six volunteers (3 M/3 F; 15.2 ± 0.5 yr; 35 ± 2 kg/mz; 39 ± 2% body fat) were studied twice following 7 d of isocaloric, isonitrogenous high carbohydrate (60% CHO; 25% fat) diets with fructose accounting for 6% and 24% of total energy intake, respectively (random order). Insulin sensitivity and secretion were analyzed by the stable labeled intravenous glucose tolerance test and glucose and lipid kinetics using GCMS. Results: A fourfold increase in dietary fructose intake did not affect insulin sensitivity or secretion, glucose kinetics, lipolysis or glucose, insulin, C-peptide, triglycerides, HDL- and LDL-cholesterol concentrations. Conclusions: In the short term, when energy intake is constant, dietary fructose per se is not a contributor to insulin resistance and hypersecretion in obese adolescents. KEY WORDS fructose, glucose production, gluconeogenesis, insulin sensitivity, insulin secretion, stable isotopes Reprint address: Agneta L. Sunehag, M.D., Ph.D. Children's Nutrition Research Center 1100 Bates Street Houston, TX 77030, USA e-mail: asunehag@bcm.tmc.edu VOLUME 21, NO. 3 , 2 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Endocrinology and Metabolism de Gruyter

Short-term High Dietary Fructose Intake had No Effects on Insulin Sensitivity and Secretion or Glucose and Lipid Metabolism in Healthy, Obese Adolescents

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References (40)

Publisher
de Gruyter
Copyright
Copyright © 2008 by the
ISSN
0334-018X
eISSN
2191-0251
DOI
10.1515/JPEM.2008.21.3.225
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTION There is virtually no information on the metabolic impact of dietary fructose intake in adolescents despite their consumption, particularly via sweetened beverages. Aim: To determine the short-term metabolic effects of dietary fructose intake in obese adolescents. Methods: Six volunteers (3 M/3 F; 15.2 ± 0.5 yr; 35 ± 2 kg/mz; 39 ± 2% body fat) were studied twice following 7 d of isocaloric, isonitrogenous high carbohydrate (60% CHO; 25% fat) diets with fructose accounting for 6% and 24% of total energy intake, respectively (random order). Insulin sensitivity and secretion were analyzed by the stable labeled intravenous glucose tolerance test and glucose and lipid kinetics using GCMS. Results: A fourfold increase in dietary fructose intake did not affect insulin sensitivity or secretion, glucose kinetics, lipolysis or glucose, insulin, C-peptide, triglycerides, HDL- and LDL-cholesterol concentrations. Conclusions: In the short term, when energy intake is constant, dietary fructose per se is not a contributor to insulin resistance and hypersecretion in obese adolescents. KEY WORDS fructose, glucose production, gluconeogenesis, insulin sensitivity, insulin secretion, stable isotopes Reprint address: Agneta L. Sunehag, M.D., Ph.D. Children's Nutrition Research Center 1100 Bates Street Houston, TX 77030, USA e-mail: asunehag@bcm.tmc.edu VOLUME 21, NO. 3 , 2

Journal

Journal of Pediatric Endocrinology and Metabolismde Gruyter

Published: Mar 1, 2008

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