SHORT COMMUNICATION

SHORT COMMUNICATION Hoppe-Seyler's Z. Physiol. Chem. Bd. 357, S. 601 - 604, April 1976 SHORT COMMUNICATION Isolation of a Procollagen Peptide from Amniotic Fluid Hans NOWACK, Heilwig ROHDE and Rupert TIMPL Max-Planck-Institut für Biochemie, Abt. Bindegewebsforschung, Martinsried bei München (Received 12 February 1976) Isolierung eines Prokollagen-Peptids aus Amnionflüssigkeit Zusammenfassung: Aus Rinderamnionflüssigkeit wurde ein Peptid mit einem Molekulargewicht von ca. 15000 isoliert. Dieses Peptid war immunologisch identisch mit dem aminoterminalen Peptid der pro l (I)-Kette aus Prokollagen und bestand aus einer globulären und kollagen-ähnlichen Region. Die Ergebnisse weisen darauf hin, daß der aminoterminale Teil des Prokollagens durch Proteasen als gesamte Einheit abgespalten wird. Key words: Procollagen catabolism, peptide structure, radioimmune assay Collagens are formed from larger bio synthetic precursors, the procollagens, which have additional peptide segments at the amino and carboxyl ends of each chain. Current evidence suggests that the precursor-specific peptides arc removed en bloc^ 1"51 and persist for some time in the body^ 6 ' 7 '. Using immunological methods, materials reacting with antibody against determinants in the arnino-terminal portion of the proa 1 (I) chain have been detected in biological fluids'8]. In the present study we have isolated the antigenically active materials from amniotic fluid and compared their http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png hoppe-seyler's zeitschrift für physiologische chemie de Gruyter

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Publisher
de Gruyter
Copyright
Copyright © 1976 by the
ISSN
0018-4888
eISSN
1437-4315
DOI
10.1515/bchm2.1976.357.1.601
Publisher site
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Abstract

Hoppe-Seyler's Z. Physiol. Chem. Bd. 357, S. 601 - 604, April 1976 SHORT COMMUNICATION Isolation of a Procollagen Peptide from Amniotic Fluid Hans NOWACK, Heilwig ROHDE and Rupert TIMPL Max-Planck-Institut für Biochemie, Abt. Bindegewebsforschung, Martinsried bei München (Received 12 February 1976) Isolierung eines Prokollagen-Peptids aus Amnionflüssigkeit Zusammenfassung: Aus Rinderamnionflüssigkeit wurde ein Peptid mit einem Molekulargewicht von ca. 15000 isoliert. Dieses Peptid war immunologisch identisch mit dem aminoterminalen Peptid der pro l (I)-Kette aus Prokollagen und bestand aus einer globulären und kollagen-ähnlichen Region. Die Ergebnisse weisen darauf hin, daß der aminoterminale Teil des Prokollagens durch Proteasen als gesamte Einheit abgespalten wird. Key words: Procollagen catabolism, peptide structure, radioimmune assay Collagens are formed from larger bio synthetic precursors, the procollagens, which have additional peptide segments at the amino and carboxyl ends of each chain. Current evidence suggests that the precursor-specific peptides arc removed en bloc^ 1"51 and persist for some time in the body^ 6 ' 7 '. Using immunological methods, materials reacting with antibody against determinants in the arnino-terminal portion of the proa 1 (I) chain have been detected in biological fluids'8]. In the present study we have isolated the antigenically active materials from amniotic fluid and compared their

Journal

hoppe-seyler's zeitschrift für physiologische chemiede Gruyter

Published: Jan 1, 1976

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