Smith et ah, Current concepts of reproductive immuno-biology J. Perinat. Med. 4(1976) 59 Current concepts of reproductive immuno-biology W. G. Smith, A. E. Beer During the past ten years, there has been a great deal of progress in elucidating the essential immunogenetic prerequisites necessary for the primary take or healing in of the blastocyst on the uterine bed, the cellular interactions with its bed, the development of the resultant fetal organismic graft, and its ultimate and prompt repudiation at term. Contrary to various hypotheses that have been advanced äs to the Immunologie non-reactivity of the mother during gestation, females do become immunologically cognizant of the presence in their uteri of genetically alien fetuses. The human conceptus by virtue of its inherited paternal antigens fulfills the definition of an allograft and predicting from all other known graft behavior, should be rejected. Coeval with the evolution of viviparity, Nature has had to solve the problem of nourishing the embryo within the uterus, a paradoxical Situation which seems to defy the known laws of transplantation biology. The resultant immunological interrelationships between mother and offspring have been the object of intense research, the results of which demonstrate both beneficial and harmful effects
Journal of Perinatal Medicine – de Gruyter
Published: Jan 1, 1976
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